ChemicalBook >> CAS DataBase List >>(R)-N-Boc-glutamic acid-1,5-dimethyl ester
(R)-N-Boc-glutamic acid-1,5-dimethyl ester
- CAS No.
- 59279-60-6
- Chemical Name:
- (R)-N-Boc-glutamic acid-1,5-dimethyl ester
- Synonyms
- N-Boc-L-Glutamic acid dimethyl ester;BOC-GLU(OME)-OME;BOC-L-GLU(OME)-OME;Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate;BOC-GLU(OME)-OME 45G;BOC-L-GLUTAMIC ACID DIMETHYL ESTER;dimethyl(tert-butoxycarbonyl)-L-glutamate;(S)-diMethyl 2-(tert-butoxycarbonylaMino)pentanedioate;BOC-L-GLU(ME)-OME;Dimethyl (2S)-2-(tert-butoxycarbonylamino)pentanedioate
- CBNumber:
- CB5853917
- Molecular Formula:
- C12H21NO6
- Molecular Weight:
- 275.3
- MDL Number:
- MFCD03094774
- MOL File:
- 59279-60-6.mol
- MSDS File:
- SDS
Last updated:2024-11-01 18:09:03
| Melting point | 43.0 to 47.0 °C |
|---|---|
| Boiling point | 370.9±32.0 °C(Predicted) |
| Density | 1.117±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| pka | 10.86±0.46(Predicted) |
| form | Liquid |
| color | Colorless to pale yellow |
| InChI | InChI=1S/C12H21NO6/c1-12(2,3)19-11(16)13-8(10(15)18-5)6-7-9(14)17-4/h8H,6-7H2,1-5H3,(H,13,16)/t8-/m0/s1 |
| InChIKey | QNSPKWUAZQIIGZ-QMMMGPOBSA-N |
| SMILES | C(OC)(=O)[C@H](CCC(OC)=O)NC(OC(C)(C)C)=O |
| CAS DataBase Reference | 59279-60-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| HS Code | 2922420090 | |||||||||
| NFPA 704 |
|
(R)-N-Boc-glutamic acid-1,5-dimethyl ester price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D4536 | Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate >98.0%(HPLC)(N) | 59279-60-6 | 1g | $30 | 2024-03-01 | Buy |
| TCI Chemical | D4536 | Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate >98.0%(HPLC)(N) | 59279-60-6 | 5g | $87 | 2024-03-01 | Buy |
| Alfa Aesar | H62056 | N-Boc-L-glutamic acid 1,5-dimethyl ester, 97% | 59279-60-6 | 5g | $62.65 | 2024-03-01 | Buy |
| Alfa Aesar | H62056 | N-Boc-L-glutamic acid 1,5-dimethyl ester, 97% | 59279-60-6 | 25g | $260.65 | 2024-03-01 | Buy |
| TRC | B600185 | N-Boc-L-glutamicAcid1,5-DimethylEster | 59279-60-6 | 5g | $80 | 2021-12-16 | Buy |
(R)-N-Boc-glutamic acid-1,5-dimethyl ester Chemical Properties,Uses,Production
Uses
(R)-N-Boc-glutamic acid-1,5-dimethyl ester can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical production processes.
Synthesis
L-glutamic acid (10.0 g, 67.97 mmol) was dissolved in 200 mL of methanol, and SOCl2(10.85 mL, 149.53 mmol)was slowly added dropwise under an ice bath. After the addition, reflux was performed at 65 ?? C. After 2 hours, the reaction system was cooled to room temperature, and methanol was evaporated to dryness under reduced pressure to obtain a colorless viscous substance.This colorless viscous substance was dissolved in 200 mL of THF, (Boc)2O (22.25 g, 101.95 mmol) was addedunder an ice bath, and triethylamine (14.13 mL, 101.95 mmol) was slowly added dropwise.After the addition was complete, the reaction was allowed to proceed at room temperature overnight.After completion of the reaction, the solvent was distilled off under reduced pressure.The residue was dissolved in 200 mL of dichloromethane.The organic phase was washed with water (200 mL * 2), saturated citric acid solution (200 mL * 2), saturated sodium bicarbonate solution (200 mL * 2), and saturated brine (200 mL * 2) in that order.The organic phase was dried over anhydrous Na2SO4. Thefiltrate was collected by filtration, and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography (petroleum ether: ethyl acetate = 4: 1 v / v) to give a colorless oily product (R)-N-Boc-glutamic acid-1,5-dimethyl ester (18.34 g, yield 98%)
(R)-N-Boc-glutamic acid-1,5-dimethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 323)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| AstaTech(Chengdu) Biopharmaceutical Corp. | +86-02882666559 +86-15884417729 | gjpu@astatech.com.cn | China | 308 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14395 | 58 |
| JUYE XIANDAI fine chemistry Co.,Ltd | +86-18958038633; +8618958038633 | tony@sdhypharma.com | China | 64 | 58 |
| Unibest Industrial Co.,Ltd. | +86-8657427855777 +86-18758850676 | info@unibestcn.com | China | 227 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12839 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5892 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18153 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 427 | 58 |
View Lastest Price from (R)-N-Boc-glutamic acid-1,5-dimethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-28 | Boc-L-Glu(Ome)-Ome
59279-60-6
|
US $0.00-0.00 / kg | 1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | |
 |
2024-11-27 | Boc-L-Glu(OMe)-OMe
59279-60-6
|
US $0.00 / Kg/Drum | 1KG | 98%min | 500kgs | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-11-06 | (R)-N-Boc-glutamic acid-1,5-dimethyl ester
59279-60-6
|
US $0.00-0.00 / kg | 0.10000000149011612kg | 99 | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. |
-
- Boc-L-Glu(Ome)-Ome
59279-60-6
- US $0.00-0.00 / kg
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- Boc-L-Glu(OMe)-OMe
59279-60-6
- US $0.00 / Kg/Drum
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- (R)-N-Boc-glutamic acid-1,5-dimethyl ester
59279-60-6
- US $0.00-0.00 / kg
- 99
- Chongqing Zhihe Biopharmaceutical Co., Ltd.
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