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2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]-

2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]- structure

CAS No.: 30388-31-9

Chemical Name:: 2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]-

Synonyms: 2-cyano-3-[4-(diphenylamino)phenyl]prop-2-enoic acid;2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]-

CBNumber:: CB58603378

Molecular Formula:: C22H16N2O2

Molecular Weight:: 340.37

MDL Number:

MOL File:: 30388-31-9.mol

Last updated:2023-07-14 17:44:29

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2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]- Properties

Melting point	213-214 °C
Boiling point	546.6±45.0 °C(Predicted)
Density	1.280±0.06 g/cm3(Predicted)
pka	-99.34±0.10(Predicted)

2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]- Chemical Properties,Uses,Production

Description

DN-F01 is a potent cardiac sarcomere inhibitor, DNF01 targeting the cardiac muscle thin filament protein troponin complex. Functional studies show that DN-F01 has a strong inhibitory calcium-dependent effect on cardiac myofibrillar ATPase activity with an IC50 value of 11 ± 4 nmol/L. DN-F01 is shown to bind to a cardiac troponin C?troponin I chimera (cChimera) with a KD of ～50 nM using fluorescence spectroscopy, indicating that troponin is the likely target for DN-F01. NMR titrations of DNF01 to C35S and A-Cys cChimera show covalent and noncovalent binding of DN-F01 bound to the calcium-saturated cChimera.

2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]- Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zhengzhou convergence chemical co., LTD	0371-0371-55153829 18003835034	2853979819@qq.com	China	9857	58
Shaanxi Istare Biotechnology Co., Ltd.	18682931470	2142355700@qq.com	China	4793	58

Supplier	Advantage
Zhengzhou convergence chemical co., LTD	58
Shaanxi Istare Biotechnology Co., Ltd.	58

2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]- 2-cyano-3-[4-(diphenylamino)phenyl]prop-2-enoic acid 30388-31-9