Promazine
- CAS No.
- 58-40-2
- Chemical Name:
- Promazine
- Synonyms
- A-145;Wy-1094;RP-3276;Esparin;Promazine;NSC 31447;Sinophenin;Chlorpromazine-003;Promazine USP/EP/BP;Promazine Dimer Impurity
- CBNumber:
- CB5875452
- Molecular Formula:
- C17H20N2S
- Molecular Weight:
- 284.4191
- MDL Number:
- MFCD00242576
- MOL File:
- 58-40-2.mol
| Melting point | 25°C |
|---|---|
| Boiling point | bp0.3 203-210° |
| Density | 1.1256 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | pKa 9.4(H2O,t =24±1) (Uncertain) |
| color | Off-White to Pale Beige |
| Water Solubility | 14.22mg/L(24 ºC) |
| Stability | Hygroscopic |
| FDA UNII | O9M39HTM5W |
| ATC code | N05AA03 |
| NIST Chemistry Reference | Promazine(58-40-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Toxicity | LD50 oral in rat: 350mg/kg |
Promazine Chemical Properties,Uses,Production
Uses
ntipsychotic.
Uses
Promazine is an antipsychotic and a tranquilizer.
Uses
In psychiatric practice, promazine is used in minor cases of psychomotor excitement in schizophrenics, in paranoid and manic-depressive conditions, for neurosis, alcoholic psychosis, and others. It is sometimes used in anesthesiological practice.
Definition
ChEBI: A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.
brand name
Sparine (Baxter Healthcare); Sparine (Wyeth).
General Description
Promazine, 10-[3-(dimethylamino) propyl-(phenothiazine monohydrochloride (Sparine), was introducedinto antipsychotic therapy after its 2-chloro-substitutedrelative. The 2H-substituent vis-à-vis the 2Clsubstituent gives a milligram potency decrease as an antipsychotic,as encompassed in Gordon’s rule. Tendency toEPS is also lessened, which may be significant, especially ifit is decreased less than antipsychotic potency.
Synthesis
Promazine, 10-(3-dimethylaminopropyl)phenothiazine (6.1.1), is prepared by the alkylation of phenothiazine with 3-dimethylaminopropylchloride in the presence of sodium amide [1¨C3].
Promazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 8670 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Guangzhou PI PI Biotech Inc | 020-81716320 +86-13602409664 | Sales@pipitech.com | China | 3633 | 55 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14055 | 65 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12335 | 58 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 18042 | 56 |
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