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carbutamide

CAS No.
339-43-5
Chemical Name:
carbutamide
Synonyms
Emedan;U-6987;Oranil;Bucrol;Burcol;Nadisan;Invenol;Alentin;Bucarban;Bukarban
CBNumber:
CB5883608
Molecular Formula:
C11H17N3O3S
Molecular Weight:
271.34
MDL Number:
MFCD00025344
MOL File:
339-43-5.mol
MSDS File:
SDS
Last updated:2024-12-18 14:08:57

carbutamide Properties

Melting point 144-145°
Density 1.2840 (rough estimate)
refractive index 1.6630 (estimate)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka pKa 5.75(H2O t=25±0.02 I=0.2) (Uncertain)
color Off-White to Pale Beige
Water Solubility 535.2mg/L(37 ºC)
FDA UNII E3K8P4869P
NCI Drug Dictionary carbutamide
ATC code A10BB06
EPA Substance Registry System Benzenesulfonamide, 4-amino-N-[(butylamino)carbonyl]- (339-43-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501
Hazardous Substances Data 339-43-5(Hazardous Substances Data)
Toxicity LD50 s.c. in mice: 3 g/kg (Haack, Hagedorn)
NFPA 704
0
2 0

carbutamide price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S385433 N1-(BUTYLCARBAMOYL)-SULFANILAMIDE Aldrich 339-43-5 50mg $209 2024-03-01 Buy
TRC C183300 Carbutamide 339-43-5 5mg $80 2021-12-16 Buy
TRC C183300 Carbutamide 339-43-5 25mg $120 2021-12-16 Buy
Biosynth Carbosynth FC19809 Carbutamide 339-43-5 25mg $160 2021-12-16 Buy
Biosynth Carbosynth FC19809 Carbutamide 339-43-5 10mg $86 2021-12-16 Buy
Product number Packaging Price Buy
S385433 50mg $209 Buy
C183300 5mg $80 Buy
C183300 25mg $120 Buy
FC19809 25mg $160 Buy
FC19809 10mg $86 Buy

carbutamide Chemical Properties,Uses,Production

Chemical Properties

Off-White to Pale Peach Solid

Originator

Carbutamide,Servier

Uses

Antidiabetic.

Definition

ChEBI: Carbutamide is a sulfonamide and a member of benzenes.

Manufacturing Process

223 g of the sodium salt of acetylsulfaniamide are stirred with 223 ml of triethylene glycol. 118 g of n-butyl isothiocyanate are added to the resulting homogeneous mixture. The resulting syrup is heated to 85°C for 4 hours. The mixture is then stirred with 1000 ml of chloroform and 1000 ml of water. The chloroform layer is twice shaken with water, each time with 250 ml. The aqueous extracts are combined and rendered weakly alkaline to phenolphthalein by addition of hydrochloric acid. Unreacted acetyl sulfanilamide precipitates and filtered off. The filtrate is acidified to a pH of 6.5 by the addition of HCl. An oily precipitate settles from the reaction solution and is separated therefrom. N-Butyl acetyl sulfanilylthiourea is precipitated from mother liquors obtained thereby by addition of HCl until Congo paper changes its color to blue. 210 g N-butyl acetyl sulfanilylthiourea are dissolved in 1400 ml of acetone while heating. The solution is mixed with 500 ml of water. A solution of 63 g of sodium nitrite in 120 ml of water is added thereto within about 45 minutes while stirring and cooling to 15°-20°C.
A suspension of crystals is obtained. 240 ml of 25% glacial acid are added thereto within 30 minutes. Stirring of the mixture is continued for 6 hours. N-Butyl acetyl sulfanilylurea mixed with sulfur is precipitated and filtered off. The crude reaction product is suspended in 1000 ml of water and is rendered weakly alkaline to phenolphthalein. Undissolved sulfur is filtered off. The filtrate is acidified by the addition of HCl. 250 g of N-butyl acetyl sulfanilylthiourea having a melting point of 186°-189°C are obtained. It is heated with 500 ml of 5 N potassium hydroxide solution to a temperature of 92°C for 2 hours while stirring. The solid reaction product is dissolved by heating with 750 ml of water and is purified by means of activated charcoal. The resulting solution is heated to 60°C and acidified by addition of HCl. 187 g of N-butyl acetyl sulfanilylthiourea melting at 139°-141°C obtained thereby.

Therapeutic Function

Oral hypoglycemic

Safety Profile

A poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NO, and SOx.

carbutamide Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 73)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32957 60
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22963 58
TargetMol Chemicals Inc.
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Shaanxi Dideu Medichem Co. Ltd
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Nanjing Doge Biomedical Technology Co., Ltd
+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2123 70

View Lastest Price from carbutamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Carbutamide pictures 2024-11-19 Carbutamide
339-43-5
US $53.00-147.00 / mg 98.77% 10g TargetMol Chemicals Inc.
carbutamide pictures 2019-09-02 carbutamide
339-43-5
US $1.00 / KG 1KG 98% 1lg; 2kg; 5kg; 10kg; 100kg Career Henan Chemical Co
  • Carbutamide pictures
  • Carbutamide
    339-43-5
  • US $53.00-147.00 / mg
  • 98.77%
  • TargetMol Chemicals Inc.
  • carbutamide pictures
  • carbutamide
    339-43-5
  • US $1.00 / KG
  • 98%
  • Career Henan Chemical Co
carbutamide UREA,1-BUTYL-3-SULFANILYL- UREA,1-BUTYL-3-SULPHANILYL 1-(4-aminophenyl)sulfonyl-3-butyl-urea Emedan Invenol Nadisan Oranil U-6987 1-(4-azanylphenyl)sulfonyl-3-butyl-urea 1-Butyl-3-sulfanilylurea Alentin AMinophenurobutane Bucarban Bucrol Bukarban Burcol Butisulfina CarbutaMid Diaboral Glucidoral N1-(ButylcarbaMoyl) sulfanilaMide 4-Amino-N-(butylcarbamoyl)benzenesulfonamide Benzenesulfonamide, 4-amino-N-[(butylamino)carbonyl]- carbutamide USP/EP/BP Benzenesulfonamide,4-amino-N-[(butylamino)carbony Inhibitor,BZ-55,first-generation,orally,Anti-diabetic,inhibit,Carbutamide,BZ 55,hypoglycemic,BZ55,sulfonylurea 339-43-5 Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds Amines Aromatics