ChemicalBook >> CAS DataBase List >>Piperazine, 1-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-4-[(4-methoxyphenyl)sulfonyl]-

Piperazine, 1-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-4-[(4-methoxyphenyl)sulfonyl]-

Piperazine, 1-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-4-[(4-methoxyphenyl)sulfonyl]- structure

CAS No.: 562867-96-3

Chemical Name:: Piperazine, 1-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-4-[(4-methoxyphenyl)sulfonyl]-

Synonyms: BML283;Piperazine, 1-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-4-[(4-methoxyphenyl)sulfonyl]-

CBNumber:: CB58930843

Molecular Formula:: C19H22N2O7S2

Molecular Weight:: 454.52

MDL Number:

MOL File:: 562867-96-3.mol

Last updated:2023-05-04 17:34:40

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Piperazine, 1-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-4-[(4-methoxyphenyl)sulfonyl]- Properties

Boiling point	638.0±65.0 °C(Predicted)
Density	1.438±0.06 g/cm3(Predicted)
storage temp.	-20°
solubility	Soluble in DMSO (up to 10 mg/ml).
form	solid
pka	-6.84±0.70(Predicted)
color	White
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.

Piperazine, 1-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-4-[(4-methoxyphenyl)sulfonyl]- Chemical Properties,Uses,Production

Description

BML283 (562867-96-3) is a selective activator of the Tumor Specific M2 Isoform of Pyruvate Kinase (PKM2) – AC50?= 111nM.1?PKM2 activity is downregulated in most cancer cells leading to a decrease in catabolic metabolism and an increase in anabolic metabolism.2,3?BML283 is an important tool for studying the effects of PKM2 and cancer metabolism.

Definition

ChEBI: 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-(4-methoxyphenyl)sulfonylpiperazine is a sulfonamide.

References

1) Boxer?et al., (2010),?Evaluation of N,N’-Diarylsulfonamides as Activators of the Tumor Specific M2 Isoform of Pyruvate Kinase; J. Med. Chem.,?53?1048 2) Israelsen?et al. (2013),?PKM2 Isoform-Specific Deletion Reveals A Differential Requirement for Pyruvate Kinase in Tumor Cells; Cell?155?397 3) Wong?et al. (2015),?PKM2 contributes to cancer metabolism; Cancer Lett.?356?184

Piperazine, 1-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-4-[(4-methoxyphenyl)sulfonyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Piperazine, 1-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-4-[(4-methoxyphenyl)sulfonyl]- Suppliers

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Supplier	Tel	Email	Country	ProdList	Advantage
Focus Biomolecules	--	sales@focusbiomolecules.com	United States	1284	58

Supplier	Advantage
Focus Biomolecules	58

562867-96-3(Piperazine, 1-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-4-[(4-methoxyphenyl)sulfonyl]-)Related Search:

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Piperazine, 1-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-4-[(4-methoxyphenyl)sulfonyl]- BML283 562867-96-3