Hexamidine diisethionate
- CAS No.
- 659-40-5
- Chemical Name:
- Hexamidine diisethionate
- Synonyms
- SymCalmin;Desomedine;Elestab HP 100;Hexamidine 2-hydroxyethansulfonate;2535RP;HD-100;HP-100;RP-2535;Esomedina;Ophtamedine
- CBNumber:
- CB5901139
- Molecular Formula:
- C22H32N4O6S
- Molecular Weight:
- 480.58
- MDL Number:
- MFCD04112907
- MOL File:
- 659-40-5.mol
- MSDS File:
- SDS
| Melting point | 246-247° (dec) |
|---|---|
| Density | 671[at 20℃] |
| vapor pressure | 0Pa at 20℃ |
| solubility | Sparingly soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride |
| Water Solubility | 48.2g/L at 20℃ |
| InChIKey | NBVZMBLJRHUOJR-UHFFFAOYSA-N |
| SMILES | C(CO)S(O)(=O)=O.O(C1C=CC(C(N)=N)=CC=1)CCCCCCOC1C=CC(C(N)=N)=CC=1 |
| LogP | 4.47 at 25℃ |
| EWG's Food Scores | 1 |
| FDA UNII | 023XA5Z50L |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P273-P391-P501 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
Hexamidine diisethionate price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H0330000 | Hexamidine diisethionate European Pharmacopoeia (EP) Reference Standard | 659-40-5 | h0330000 | $153 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | CHM0079368 | 4-[6-(4-CARBAMIMIDOYLPHENOXY)HEXOXY]BENZENECARBOXIMIDAMIDE, 2-HYDROXYETHANESULFONIC ACID 95.00% | 659-40-5 | 5G | $909.56 | 2021-12-16 | Buy |
Hexamidine diisethionate Chemical Properties,Uses,Production
Description
Hexamidine diisethionate (HEX D) is an organic salt form of Hexamidine, which has been used as an antimicrobial agent in the personal care industry and in a variety of over-the-counter (OTC) products. For example, 0.05% HEX D solution (Keratosept?) is a new antimicrobial drop for the treatment of eye infections and is better tolerated than povidone iodine. In personal care, Hexamidine has adverse reactions such as photosensitivity and contact allergy. Therefore, the European safety assessment recommends that the content of HEX D in leave-on and rinse-off cosmetics should not exceed 0.1%[1-2].
Chemical Properties
White or slightly yellow powder, hygroscopic
Uses
Hexamidinediisethionate is a preservative in topical preparations and also in skin health and personal care products.
Uses
Preservative in cosmetics.
Uses
hexamidine diisethionate is an anti-microbial and preservative targeting fungi and yeast. It may also have some emollient capacities.
Flammability and Explosibility
Not classified
Contact allergens
Hexamidine is an antiseptic active against Grampositive bacteria and fungi, used as a disinfectant and a preservative in cosmetics. It induces papulo-vesicular and diffuse allergic contact dermatitis.
Toxicology
Acute oral LD(50) values of Hexamidine Diisethionate were 0.71 to 2.5 g/kg in mice and 0.75 g/kg in rats. Dermal exposure to 4 g/kg Hexamidine Diisethionate in rats or up to 9.4 ml/kg of a 0.1% Hexamidine Diisethionate solution under occlusion in rabbits produced no mortality or other signs of toxicity. The no-observed-effect level (NOEL) for oral subchronic toxicity of Hexamidine Diisethionate in rats was 50 mg/kg/day. No signs of toxicity were observed with 2% Hexamidine Diisethionate in subchronic studies using rabbits. Application of 0.1 ml of 0.11% Hexamidine Diisethionate in aqueous solution to the eyes of rabbits produced transient reactions; 0.05% produced no reactions. Slight erythema was observed with 0.10% Hexamidine Diisethionate applied to the abraded skin of 1/11 albino rabbits. A 40% solution of Hexamidine Diisethionate applied to 10% of the body surface of rats produced slight erythema, slight edema, and scabbing in some animals at varying times after treatment. Hexamidine Diisethionate was not a sensitizer in the guinea pig maximization test or in an intracutaneous guinea pig sensitization test. Hexamidine Diisethionate was not a photosensitizer in albino rabbits. Hexamidine Diisethionate was not mutagenic in a bacterial reverse mutagenicity assay or clastogenic in mammalian cells. Hexamidine Diisethionate at 0.10% did not provoke primary irritation, inflammation, or sensitization in a clinical test of 200 human subjects[1].
References
[1] Final report on the safety assessment of Hexamidine and Hexamidine Diisethionate.[J]. International Journal of Toxicology, 2007, 26 Suppl 3: 79-88. DOI:10.1080/10915810701663168.
[2] F AVOGARO. Intravitreal injections primary prevention: a case-control study.[J]. European review for medical and pharmacological sciences, 2023, 27 8: 3664-3669. DOI:10.26355/eurrev\_202304\_32153.
Hexamidine diisethionate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shangdong Yuanlitai Nutratech Co.,ltd | +8618782242822 | tatiana@yltnutra.com | China | 8 | 58 |
| QINGDAO HONG JIN CHEMCIAL CO.,LTD. | 532-83657313 | hjt@hong-jin.com | China | 228 | 58 |
| Beri Pharma Co., Ltd. | +8613417710166 | sales@zhberi.com | China | 227 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5889 | 58 |
| ZhenYiBio Technology Inc | +8615309206328 | alexxue@zhenyibio.com | China | 296 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-17333973358 | sales06@hbduling.cn | China | 8051 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
| Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 | clara@hbshengyang.com | China | 875 | 58 |
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View Lastest Price from Hexamidine diisethionate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-27 | Hexamidine diisethionate
659-40-5
|
US $79.00-38.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2024-12-26 | Hexamidine diisethionate
659-40-5
|
US $180.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-12-26 | Hexamidine diisethionate
659-40-5
|
US $500.00-300.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD |
-
- Hexamidine diisethionate
659-40-5
- US $79.00-38.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- Hexamidine diisethionate
659-40-5
- US $180.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- Hexamidine diisethionate
659-40-5
- US $500.00-300.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD