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ChemicalBook >> CAS DataBase List >>2-Thiophenesulfonamide, N-[2-[[[(3,5-dichlorophenyl)amino]carbonyl]amino]ethyl]-3-[2-(3,4-dihydroxyphenoxy)phenyl]-

2-Thiophenesulfonamide, N-[2-[[[(3,5-dichlorophenyl)amino]carbonyl]amino]ethyl]-3-[2-(3,4-dihydroxyphenoxy)phenyl]-

2-Thiophenesulfonamide, N-[2-[[[(3,5-dichlorophenyl)amino]carbonyl]amino]ethyl]-3-[2-(3,4-dihydroxyphenoxy)phenyl]- Structure
2-Thiophenesulfonamide, N-[2-[[[(3,5-dichlorophenyl)amino]carbonyl]amino]ethyl]-3-[2-(3,4-dihydroxyphenoxy)phenyl]- structure
CAS No.
1519043-97-0
Chemical Name:
2-Thiophenesulfonamide, N-[2-[[[(3,5-dichlorophenyl)amino]carbonyl]amino]ethyl]-3-[2-(3,4-dihydroxyphenoxy)phenyl]-
Synonyms
YCWE11;YCW E11;YCW-E11;YCWE11,YCW-E-11,YCW E11;2-Thiophenesulfonamide, N-[2-[[[(3,5-dichlorophenyl)amino]carbonyl]amino]ethyl]-3-[2-(3,4-dihydroxyphenoxy)phenyl]-
CBNumber:
CB59021078
Molecular Formula:
C25H21Cl2N3O6S2
Molecular Weight:
594.49
MDL Number:
MOL File:
1519043-97-0.mol
Last updated:2025-04-18 09:51:14
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2-Thiophenesulfonamide, N-[2-[[[(3,5-dichlorophenyl)amino]carbonyl]amino]ethyl]-3-[2-(3,4-dihydroxyphenoxy)phenyl]- Properties

Density 1.528±0.06 g/cm3(Predicted)
pka 9.20±0.10(Predicted)

2-Thiophenesulfonamide, N-[2-[[[(3,5-dichlorophenyl)amino]carbonyl]amino]ethyl]-3-[2-(3,4-dihydroxyphenoxy)phenyl]- Chemical Properties,Uses,Production

Description

YCW-E11 is a inhibitor of antiapoptotic Bcl-2 family proteins.

Uses

YCW-E11 is a Bcl-2, and Mcl-1 inhibitor with Ki values of 0.83 and 0.33 μM, respectively. YCW-E11 induces cell apoptosis through the mitochondrial pathway and exhibits antitumor activity. YCW-E11 can be utilized in cancer research[1].

IC 50

Bcl-2; Mcl-1

References

[1] Yang C, et al. Development of 3-phenyl-N-(2-(3-phenylureido)ethyl)-thiophene-2-sulfonamide compounds as inhibitors of antiapoptotic Bcl-2 family proteins. ChemMedChem. 2014 Jul;9(7):1436-52. DOI:10.1002/cmdc.201400058

2-Thiophenesulfonamide, N-[2-[[[(3,5-dichlorophenyl)amino]carbonyl]amino]ethyl]-3-[2-(3,4-dihydroxyphenoxy)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Thiophenesulfonamide, N-[2-[[[(3,5-dichlorophenyl)amino]carbonyl]amino]ethyl]-3-[2-(3,4-dihydroxyphenoxy)phenyl]- Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32265 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19930 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 58
2-Thiophenesulfonamide, N-[2-[[[(3,5-dichlorophenyl)amino]carbonyl]amino]ethyl]-3-[2-(3,4-dihydroxyphenoxy)phenyl]- YCW E11 YCWE11 YCW-E11 YCWE11,YCW-E-11,YCW E11 1519043-97-0 C25H21Cl2N3O6S2