9-Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, (-)-
![9-Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, (-)- Structure](CAS/20211123/GIF/66051-76-1.gif)
- CAS No.
- 66051-76-1
- Chemical Name:
- 9-Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, (-)-
- Synonyms
- L-WR-171669;Halofantrine, ( ) ,Halofantrine, ();9-Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, (-)-
- CBNumber:
- CB59312312
- Molecular Formula:
- C26H30Cl2F3NO
- Molecular Weight:
- 500.43
- MDL Number:
- MOL File:
- 66051-76-1.mol
9-Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, (-)- Properties
| Boiling point | 596.2±50.0 °C(Predicted) |
|---|---|
| Density | 1.244±0.06 g/cm3(Predicted) |
| pka | 13.57±0.20(Predicted) |
| FDA UNII | R7ADS21FSN |
9-Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, (-)- Chemical Properties,Uses,Production
Uses
(-)-Halofantrine ((-)-SKF-102886 free base; (-)-WR-171669) is an inhibitor of the malignant malaria parasite (P. falciparum) and targets multidrug-resistant P. falciparum. The pharmacokinetic parameters of (-)-Halofantrine in rats vary depending on the route of administration, distinguishing it from other isomers[1].
Definition
ChEBI: 3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)-9-phenanthrenyl]-1-propanol is a member of phenanthrenes.
in vivo
Pharmacokinetic data from rats of Halofantrine HCl under fasting conditions[1]
| Route | Dose (mg/kg) | Compound | AUC0-∞ (mg·h/L) | Cl (mL/h/kg) | Vdss (L/kg) | Vdβ (L/kg) | t1/2 (h) | Cmax (ng/mL) | tmax (h) |
| i.v. | 2; n=5 | (-)-Halofantrine | 5.02 | 199 | 3.22 | 4.64 | 16.8 | / | / |
| (+)-Halofantrine | 9.06 | 113 | 2.38 | 3.13 | 20.8 | / | / | ||
| (±)-Halofantrine | 14.1 | 143 | 3.53 | 3.60 | 18.0 | / | / | ||
| p.o. | 14; n=5 | (-)-Halofantrine | 5.49 | / | / | / | 16.6 | 556 | 2.20 |
| (+)-Halofantrine | 16.3 | / | / | / | 16.5 | 917 | 4.20 | ||
| (±)-Halofantrine | 22.5 | / | / | / | 16.4 | 1420 | 3.60 |
References
[1] Brocks DR, et al. Pharmacokinetics of halofantrine in the rat: stereoselectivity and interspecies comparisons. Biopharm Drug Dispos. 1999 Apr;20(3):165-9. DOI:10.1002/(sici)1099-081x(199904)20:3<165::aid-bdd170>3.0.co;2-z
9-Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, (-)- Preparation Products And Raw materials
Raw materials
Preparation Products
9-Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, (-)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19881 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19723 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Lastest Price from 9-Phenanthrenemethanol, 1,3-dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-, (-)- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | Halofantrine, (-)-
66051-76-1
|
US $2180.00-1670.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- Halofantrine, (-)-
66051-76-1
- US $2180.00-1670.00 / mg
- TargetMol Chemicals Inc.