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ChemicalBook >> CAS DataBase List >>1-Oxa-4,9-diazaspiro[5.5]undecan-3-one, 9-[2-(2,5-difluorophenyl)ethyl]-4-ethyl-2-methyl-, hydrochloride (1:1), (2R)-

1-Oxa-4,9-diazaspiro[5.5]undecan-3-one, 9-[2-(2,5-difluorophenyl)ethyl]-4-ethyl-2-methyl-, hydrochloride (1:1), (2R)-

1-Oxa-4,9-diazaspiro[5.5]undecan-3-one, 9-[2-(2,5-difluorophenyl)ethyl]-4-ethyl-2-methyl-, hydrochloride (1:1), (2R)- Structure
1-Oxa-4,9-diazaspiro[5.5]undecan-3-one, 9-[2-(2,5-difluorophenyl)ethyl]-4-ethyl-2-methyl-, hydrochloride (1:1), (2R)- structure
CAS No.
2535970-65-9
Chemical Name:
1-Oxa-4,9-diazaspiro[5.5]undecan-3-one, 9-[2-(2,5-difluorophenyl)ethyl]-4-ethyl-2-methyl-, hydrochloride (1:1), (2R)-
Synonyms
EST73502 hydrochloride;1-Oxa-4,9-diazaspiro[5.5]undecan-3-one, 9-[2-(2,5-difluorophenyl)ethyl]-4-ethyl-2-methyl-, hydrochloride (1:1), (2R)-
CBNumber:
CB59315762
Molecular Formula:
C19H27ClF2N2O2
Molecular Weight:
388.88
MDL Number:
MFCD32878295
MOL File:
2535970-65-9.mol
Last updated:2024-10-23 13:36:13
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1-Oxa-4,9-diazaspiro[5.5]undecan-3-one, 9-[2-(2,5-difluorophenyl)ethyl]-4-ethyl-2-methyl-, hydrochloride (1:1), (2R)- Properties

storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (128.57 mM; Need ultrasonic)
form Solid
color White to off-white

1-Oxa-4,9-diazaspiro[5.5]undecan-3-one, 9-[2-(2,5-difluorophenyl)ethyl]-4-ethyl-2-methyl-, hydrochloride (1:1), (2R)- Chemical Properties,Uses,Production

Biological Activity

EST73502 hydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with Kis of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 hydrochloride has antinociceptive activity[1]. EST73502 hydrochloride (10-40 mg/kg; p.o.) shows a dose-response analgesic effect reaching a maximum of 64% and an EC50 of 14 mg/kg in the paw pressure test in CD1 male mice[1].EST73502 hydrochloride (5 mg/kg; i.p.; twice a day; for 10 days) attenuates partial sciatic nerve ligation (PSNL)-induced mechanical allodynia in male CD1 mice[1].

References

[1]. Mónica García, et al. Discovery of EST73502, a Dual μ-Opioid Receptor Agonist and σ 1 Receptor Antagonist Clinical Candidate for the Treatment of Pain. J Med Chem. 2020 Oct 16.

1-Oxa-4,9-diazaspiro[5.5]undecan-3-one, 9-[2-(2,5-difluorophenyl)ethyl]-4-ethyl-2-methyl-, hydrochloride (1:1), (2R)- Preparation Products And Raw materials

Raw materials

Preparation Products

1-Oxa-4,9-diazaspiro[5.5]undecan-3-one, 9-[2-(2,5-difluorophenyl)ethyl]-4-ethyl-2-methyl-, hydrochloride (1:1), (2R)- Suppliers

Global( 3)Suppliers
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TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19699 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58

View Lastest Price from 1-Oxa-4,9-diazaspiro[5.5]undecan-3-one, 9-[2-(2,5-difluorophenyl)ethyl]-4-ethyl-2-methyl-, hydrochloride (1:1), (2R)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
EST73502 hydrochloride pictures 2024-10-24 EST73502 hydrochloride
2535970-65-9
 US $228.00-1400.00 / mg 10g TargetMol Chemicals Inc.
1-Oxa-4,9-diazaspiro[5.5]undecan-3-one, 9-[2-(2,5-difluorophenyl)ethyl]-4-ethyl-2-methyl-, hydrochloride (1:1), (2R)- EST73502 hydrochloride 2535970-65-9 C19H27ClF2N2O2