K114
- CAS No.
- 872201-12-2
- Chemical Name:
- K114
- Synonyms
- K114;K114,K-114;(trans,trans)-1-bromo-2,5-bis-(4-hydroxy)styrylbenzene;K114,(trans,trans)-1-Bromo-2,5-bis-(4-hydroxy)styrylbenzene;4,4'-[(2-Bromo-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol;Phenol, 4,4'-[(2-bromo-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis-;4,4'-((1E,1'E)-(2-bromo-1,4-phenylene)bis(ethene-2,1-diyl))diphenol
- CBNumber:
- CB5972713
- Molecular Formula:
- C22H17BrO2
- Molecular Weight:
- 393.27
- MDL Number:
- MFCD11045294
- MOL File:
- 872201-12-2.mol
K114 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 3144 | K114 ≥98%(HPLC) | 872201-12-2 | 10 | $123 | 2021-12-16 | Buy |
| Tocris | 3144 | K114 ≥98%(HPLC) | 872201-12-2 | 50 | $515 | 2021-12-16 | Buy |
| TRC | K000450 | K114 | 872201-12-2 | 10mg | $95 | 2021-12-16 | Buy |
| Usbiological | 255576 | K 114 | 872201-12-2 | 10mg | $366 | 2021-12-16 | Buy |
| ChemScene | CS-0027952 | K114 >99.0% | 872201-12-2 | 2mg | $110 | 2021-12-16 | Buy |
K114 Chemical Properties,Uses,Production
Uses
K 114 is a potent amyloid fibril-specific fluorescent dye. K 114 is a potent amyloid fibril-specific fluorescent dye similar to Congo Red and BSB. K 114 recognizes amyloid lesions and facilitates quantitative monitoring of the formation of amyloid fibrils assembled from the Aβ peptide, α-synuclein, and tau. The affinity for fibrils ranges 20-30 nM. Unlike the other compounds K114 has minimal fluorescence in aqueous buffers, but fluoresces brightly in the presence of amyloid fibrils. K114 can be used to monitor in vitro amyloid fibril formation by fluorescence emission at 550 nm.
Definition
ChEBI: (E,E)-1-bromo-2,5-bis-(4-hydroxystyryl)benzene is an organobromine compound that is bromobenzene in which the hydrogens at positions 2 and 5 are replaced by 4-hydroxystyryl groups. It has a role as a fluorescent dye. It is an organobromine compound and a polyphenol.
Biological Activity
Potent amyloid fibril-specific fluorescent dye (EC 50 = 20 - 30 nM). Exhibits minimal fluorescence in aqueous buffers and fluoresces brightly in the presence of A β , α -synuclein and tau in situ . (Optimum wavelength = 550 nM).
storage
Store at +4°C
K114 Preparation Products And Raw materials
Raw materials
Preparation Products
K114 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| Wuhan TCASChem Technology Co., Ltd. | 027-027-86697669 13986148687 | sales@tcaschem.com | China | 3887 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 7323 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4345 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Shenzhen Shengda Pharmaceutical co Limited | 0755-85269922 13424394241 | sales@shengdapharm.com | China | 505 | 58 |