ChemicalBook >> CAS DataBase List >>QD-394
QD-394
- CAS No.
- 2132411-21-1
- Chemical Name:
- QD-394
- Synonyms
- QD-394;QD 394,QD394;6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-5,8-quinazolinedione;5,8-Quinazolinedione, 6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-
- CBNumber:
- CB59739308
- Molecular Formula:
- C19H19N5O2
- Molecular Weight:
- 349.39
- MDL Number:
- MOL File:
- 2132411-21-1.mol
Last updated:2024-10-28 23:16:16
| Boiling point | 566.3±50.0 °C(Predicted) |
|---|---|
| Density | 1.368±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMF: 1 mg/lm,DMSO: 5 mg/ml,DMSO:PBS (pH 7.2) (1:20): 0.04 mg/ml,Ethanol: 1 mg/lm,PBS (pH 7.2): slightly soluble |
| form | A crystalline solid |
| pka | 7.92±0.42(Predicted) |
| color | Brown to black |
QD-394 Chemical Properties,Uses,Production
Biological Activity
QD-394 is an inducer of reactive oxygen species (ROS) production.1 It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 μM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 μM, respectively). QD-394 acts synergistically with napabucasin to reduce colony formation in MIA PaCa-2 cells.
References
1.Hu, S., Sechi, M., Singh, P.K., et al.A novel redox modulator induces a GPX4-mediated cell death that is dependent on iron and reactive oxygen speciesJ. Med. Chem.63(17)9838-9855(2020)
QD-394 Preparation Products And Raw materials
Raw materials
Preparation Products
QD-394 Suppliers
Global( 6)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| ChemeGen 中国 | 18818260767 | 2625930290@qq.com | China | 6973 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1248 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11974 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19707 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| ChemeGen 中国 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
QD-394
QD 394,QD394
5,8-Quinazolinedione, 6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-
6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-5,8-quinazolinedione
2132411-21-1