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Benzamide, 5-chloro-2-methoxy-N-[2-[4-[(methylamino)sulfonyl]phenyl]ethyl]-

Benzamide, 5-chloro-2-methoxy-N-[2-[4-[(methylamino)sulfonyl]phenyl]ethyl]- structure

CAS No.: 1638611-48-9

Chemical Name:: Benzamide, 5-chloro-2-methoxy-N-[2-[4-[(methylamino)sulfonyl]phenyl]ethyl]-

Synonyms: JC124;JC 124;JC-124;5-Chloro-2-methoxy-N-(4-(N-methylsulfamoyl)phenethyl)benzamide;Benzamide, 5-chloro-2-methoxy-N-[2-[4-[(methylamino)sulfonyl]phenyl]ethyl]-

CBNumber:: CB59783129

Molecular Formula:: C17H19ClN2O4S

Molecular Weight:: 382.86

MDL Number:: MFCD34469277

MOL File:: 1638611-48-9.mol

Last updated:2024-07-02 08:55:12

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Benzamide, 5-chloro-2-methoxy-N-[2-[4-[(methylamino)sulfonyl]phenyl]ethyl]- Properties

Density	1.304±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
form	Solid
pka	11.54±0.30(Predicted)
color	Light yellow to yellow

Benzamide, 5-chloro-2-methoxy-N-[2-[4-[(methylamino)sulfonyl]phenyl]ethyl]- Chemical Properties,Uses,Production

Biological Activity

JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects[1]. JC124 shows selective inhibition of NLRP3 inflammasome formation and activation of caspase-1, and reduction of IL-1β both in vitro[1]. JC124 (100 mg/kg; i.p.; 4 doses; 30 min post-injury, 6, 24, and 30 h after TBI) treatment significantly decreases the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume. JC124 also significantly reduces protein expression levels of NLRP3, ASC, IL-1 beta, TNFα, iNOS, and caspase-1[1].

References

[1]. Ram Kuwar, et al. A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury. J Neuroinflammation. 2019 Apr 11;16(1):81.

Benzamide, 5-chloro-2-methoxy-N-[2-[4-[(methylamino)sulfonyl]phenyl]ethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzamide, 5-chloro-2-methoxy-N-[2-[4-[(methylamino)sulfonyl]phenyl]ethyl]- Suppliers

Global( 11)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9887	58
Shanghai Dongyang Biotechnology Co., Ltd.	0512-0512-13601744364 13601744364	chemsharker@126.com	China	890	58
Jinan Jiuli Biotechnology Co. , Ltd.	14768611851	486064515@qq.com	China	2277	58
Bide Pharmatech Ltd.	400-1647117 15221909166	product02@bidepharm.com	China	63720	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4455	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	5593	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Shanghai Chaolan Chemical Technology Center	58
Shanghai Dongyang Biotechnology Co., Ltd.	58
Jinan Jiuli Biotechnology Co. , Ltd.	58
Bide Pharmatech Ltd.	58
TargetMol Chemicals Inc.	58
Nantong QuanYi Biotechnology Co., Ltd	58
Nanjing Tengyi Biotechnology Co., Ltd	58

Benzamide, 5-chloro-2-methoxy-N-[2-[4-[(methylamino)sulfonyl]phenyl]ethyl]- Spectrum

Benzamide, 5-chloro-2-methoxy-N-[2-[4-[(methylamino)sulfonyl]phenyl]ethyl]-(1638611-48-9)¹HNMR

Benzamide, 5-chloro-2-methoxy-N-[2-[4-[(methylamino)sulfonyl]phenyl]ethyl]- JC 124 JC124 JC-124 5-Chloro-2-methoxy-N-(4-(N-methylsulfamoyl)phenethyl)benzamide 1638611-48-9