ChemicalBook >> CAS DataBase List >>Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) structure

CAS No.: 176199-48-7

Chemical Name:: Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

Synonyms: LY 354740;Eglumetad;Eglumegad;(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid;Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S...;Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid,2-amino-,(1S,2S,5R,6S)-;Bicyclo[3.1.0]hexane-2,6-dicarboxylicacid, 2-aMino-, [1S-(1a,2b,5a,6a)]-;Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)

CBNumber:: CB61042715

Molecular Formula:: C8H11NO4

Molecular Weight:: 185.18

MDL Number:

MOL File:: 176199-48-7.mol

MSDS File:: SDS

Last updated:2024-07-02 08:55:12

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Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Properties

Melting point	270-271 °C
Boiling point	376.4±32.0 °C(Predicted)
Density	1.569
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	H2O : 6.33 mg/mL (34.18 mM; Need ultrasonic and warming)
form	Powder
pka	2.06±0.40(Predicted)
color	White to off-white
FDA UNII	ONU5A67T2S

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P280-P301+P312-P302+P352-P305+P351+P338

NFPA 704

	0
2		0

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	5.04685	LY 354740 - CAS 176199-48-7 - Calbiochem	176199-48-7	10MG	$156	2022-05-15	Buy
Cayman Chemical	24215	LY354740 ≥95%	176199-48-7	1mg	$33	2024-03-01	Buy
Cayman Chemical	24215	LY354740 ≥95%	176199-48-7	5mg	$106	2024-03-01	Buy
Cayman Chemical	24215	LY354740 ≥95%	176199-48-7	10mg	$160	2024-03-01	Buy
Tocris	3246	LY354740 ≥98%(HPLC)	176199-48-7	10	$208	2021-12-16	Buy

Product number	Packaging	Price	Buy
5.04685	10MG	$156	Buy
24215	1mg	$33	Buy
24215	5mg	$106	Buy
24215	10mg	$160	Buy
3246	10	$208	Buy

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Chemical Properties,Uses,Production

Uses

LY 354740 is a highly selective and potent agonist of group II mGluR.

Uses

Treatment ofgeneral anxiety disorders and smoking cessation (metabotropic glutamate agonist).

Definition

ChEBI: Eglumetad is a L-alpha-amino acid.

Biological Activity

Highly selective and potent agonist of group II mGlu receptors (EC 50 values are 5.1 and 24.3 nM at mGlu 2 and mGlu 3 receptors respectively and > 100000 nM at mGlu 4 , mGlu 7 , mGlu 1a and mGlu 5a receptors). Displays antianxiety and antiaddictive activity in vivo . Orally and systemically active.

storage

+4°C

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) synthesis

Synthesis of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) from Spiro[cyclohexane-1,2'-cyclopropa[3,4]cyclopenta[1,2-d][1,3]dioxole]-4'-carboxylic acid, hexahydro-5'-oxo-, ethyl ester, (3'aR,3'bR,4'S,4'aS,5'aR)-

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Preparation Products And Raw materials

Raw materials

Spiro[bicyclo[3.1.0]hexane-2,4'-imidazolidine]-6-carboxylic acid, 2',5'-dioxo-, ethyl ester, (1S,2S,5R,6S)-

Preparation Products

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Suppliers

Global( 73)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33338	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
InvivoChem	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58

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Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Eglumegad Eglumetad LY 354740 (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid Bicyclo[3.1.0]hexane-2,6-dicarboxylicacid, 2-aMino-, [1S-(1a,2b,5a,6a)]- Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid,2-amino-,(1S,2S,5R,6S)- Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S... 176199-48-7 CYCLOPENTANE Glutamate