ChemicalBook >> CAS DataBase List >>2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) structure

CAS No.: 59989-18-3

Chemical Name:: 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)

Synonyms: GW-776;GW776C85;ADH-300004;NSC 687296;5-ethynyluracil;5-Ethynyluracil>13C,15N2]-Eniluracil;Eniluracil (5-Ethynyluracil;5-Ethynyl-1H-pyrimidine-2,4-dione;5-Ethynyl-2,4(1H,3H)-pyriMidinedione

CBNumber:: CB61081129

Molecular Formula:: C6H4N2O2

Molecular Weight:: 136.11

MDL Number:: MFCD00871973

MOL File:: 59989-18-3.mol

MSDS File:: SDS

Last updated:2024-11-19 20:33:22

Request For Quotation

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Properties

Melting point	320° (dec)
Density	1.527
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Soluble in DMSO
form	solid
pka	7.44±0.10(Predicted)
color	Yellow
λmax	284nm(MeOH)(lit.)
Merck	14,3584
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
FDA UNII	2E2W0W5XIU

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

HS Code

2933.59.9500

NFPA 704

	0
2		0

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	E1096	5-Ethynyluracil >97.0%(HPLC)(T)	59989-18-3	200mg	$201	2024-03-01	Buy
TCI Chemical	E1096	5-Ethynyluracil >97.0%(HPLC)(T)	59989-18-3	1g	$696	2024-03-01	Buy
TRC	E558650	Eniluracil	59989-18-3	10mg	$55	2021-12-16	Buy
TRC	E558650	Eniluracil	59989-18-3	1g	$495	2021-12-16	Buy
American Custom Chemicals Corporation	API0005199	ENILURACIL 95.00%	59989-18-3	100MG	$779.63	2021-12-16	Buy

Product number	Packaging	Price	Buy
E1096	200mg	$201	Buy
E1096	1g	$696	Buy
E558650	10mg	$55	Buy
E558650	1g	$495	Buy
API0005199	100MG	$779.63	Buy

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Chemical Properties,Uses,Production

Description

Eniluracil (59989-18-3) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor.1-3? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Eniluracil has been used along with 5-FU to prolong circulating concentrations of the drug.

Uses

Potent inactivator of Dihydropyrimidine dehydrogenase (DPD).

Definition

ChEBI: Eniluracil is a pyrimidone.

References

1) Porter?et al. (1992),?Mechanism-based Inactivation of Dihydropyrimidine Dehydrogenase by 5-Ethynyluracil; J. Biol. Chem.,?267?5236 2) Baccalnari?et al. (1993),?5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil; Proc. Natl. Acad. Sci. USA,?90?11064 3) Schilsky and Kindler (2000)?Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase; Expert Opin. Investig. Drugs,?9?1635

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Suppliers

Global( 65)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10310	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8838	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30240	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Wuhu Nuowei chemistry Co., Ltd.	+86-0553-2911116-802 +undefined17756524438	sales1@nuowei-chem.com	China	1638	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38632	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58

Supplier	Advantage
Shenzhen Nexconn Pharmatechs Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Labnetwork lnc.	58
InvivoChem	58
Wuhu Nuowei chemistry Co., Ltd.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58

View Lastest Price from 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	Eniluracil 59989-18-3	US $39.00-108.00 / mg		98.79%	10g	TargetMol Chemicals Inc.

Eniluracil
59989-18-3
US $39.00-108.00 / mg
98.79%
TargetMol Chemicals Inc.

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Spectrum

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)(59989-18-3)¹HNMR

59989-18-3(2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI))Related Search:

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Netivudine CHROMATIDE(TM) TEXAS RED(R)-5-DUTP FLUORESCEIN-12-UTP BIOTIN-11-DDUTP

FLUORESCEIN-12-DUTP DIETHYLAMINOCOUMARIN-5-DUTP FLUORESCEIN CHLOROTRIAZINYL-4-UTP LISSAMINE-5-UTP COUMARIN-5-DDUTP

FLUORESCEIN CHLOROTRIAZINYL-4-DUTP NAPHTHOFLUORESCEIN-5-UTP COUMARIN-5-DUTP CHROMATIDE(TM) TEXAS RED(R)-5-UTP LISSAMINE-5-DUTP

COUMARIN-5-UTP TETRAMETHYLRHODAMINE-6-UTP NAPHTHOFLUORESCEIN-5-DUTP

1of4

5-ethynyluracil 5-Ethynyl-2,4(1H,3H)-pyriMidinedione NSC 687296 GW776C85 ADH-300004 GW-776 5-EthynylpyriMidine-2,4(1H,3H)-dione 5-Ethynyl-1H-pyrimidine-2,4-dione 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) 5-Ethynyluracil> 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- Eniluracil (5-Ethynyluracil 13C,15N2]-Eniluracil 5-fluorouracil,cancer,Inhibitor,inhibit,Eniluracil,5-FU,tumor,combination 59989-18-3 Nucleotides Pharmaceuticals PYRIMIDINE Bases & Related Reagents Intermediates & Fine Chemicals