SUBSTANCE P
- CAS No.
- 12769-48-1
- Chemical Name:
- SUBSTANCE P
- Synonyms
- RPKPQFFGLM;SUBSTANCE P;RPKPQQFFGLM-NH2;SUBSTANCE P AMIDE;SUBSTANCE P (TYR8);SUBSTANCE P BOVINE;SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE);SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11];ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET
- CBNumber:
- CB6114259
- Molecular Formula:
- C63H98N18O13S
- Molecular Weight:
- 1347.63
- MDL Number:
- MFCD00076780
- MOL File:
- 12769-48-1.mol
| storage temp. | -20°C |
|---|---|
| EWG's Food Scores | 1 |
| FDA UNII | 675VGV5J1D |
SUBSTANCE P price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J66954 | Substance P reversed sequence | 12769-48-1 | 5mg | $87.7 | 2021-12-16 | Buy |
| Tocris | 1156 | Substance P | 12769-48-1 | 5 | $163 | 2021-12-16 | Buy |
| Usbiological | 242082 | Substance P | 12769-48-1 | 100mg | $269 | 2021-12-16 | Buy |
| Usbiological | S8000-14J | Substance P [D-Arg1, D-Pro2, D-Trp7,9, Leu11] | 12769-48-1 | 5mg | $336 | 2021-12-16 | Buy |
| Usbiological | S8000-15A | Substance P | 12769-48-1 | 1mg | $489 | 2021-12-16 | Buy |
SUBSTANCE P Chemical Properties,Uses,Production
Uses
Substance P is a neurokinin undecapeptide neurotransmitter and neuromodulator.
Definition
ChEBI: Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurotransmitter, a vasodilator agent and a neurokinin-1 receptor agonist. It is a conjugate base of a substance P(3+).
Mechanism of action
Substance P is an 11-amino-acid neuropeptide belonging to the tachykinin family, mediating its biological actions through activation of G protein–coupled tachykinin (neurokinin-1 [NK1]) receptors. Its proposed physiological roles include inflammation, pain, GI and respiratory function, stress responses, and emesis. Substance P is uniquely associated with the monoamine neurotransmitters, 5-HT and NE.
Clinical Use
The 5-HT neurons coexpress substance P, and the firing of NE neurons is modulated by substance P. Preclinical studies have supported a role of the substance P–NK1 receptor system in stress-related disorders, which has guided the antidepressant development of centrally active NK1 receptor antagonists, such as aprepitant. The NK1 antagonists are generally well tolerated and exhibit less nausea and sexual dysfunction than some currently used antidepressants.
SUBSTANCE P Preparation Products And Raw materials
Raw materials
Preparation Products
SUBSTANCE P Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
| Hangzhou Go Top Peptide Biotech | 0571-88211921 | sales1@gotopbio.com | CHINA | 2609 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42982 | 64 |
| Nanjing Leon Biological Technology Co., Ltd. | 18751916801 | 1005482778@qq.com | China | 5503 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-025-58361106-805-805 13082558573 | liugang@njpeptide.com | China | 9962 | 55 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | eric@peptidego.com | China | 6526 | 58 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 6213 | 58 |
| Baoji Didu Pharmaceutical and Chemical Co., Ltd | 029-61856358 15829046862 | 1035@dideu.com | China | 10011 | 58 |
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