2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid
- CAS No.
- 484-78-6
- Chemical Name:
- 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid
- Synonyms
- NSC 96400;Paralysin II;3-hydroxykynurenine;DL-Hydroxykynurenine;rac 3-Hydroxy Kynurenine;13C6]-3-hydroxykynurenine;3-(3-Hydroxyanthraniloyl)alanine;REF DUPL: DL-3-Hydroxykynurenine;Benzenebutanoic acid, α,2-diamino-3-hydroxy-γ-oxo-;2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid
- CBNumber:
- CB61236011
- Molecular Formula:
- C10H12N2O4
- Molecular Weight:
- 224.21
- MDL Number:
- MOL File:
- 484-78-6.mol
- MSDS File:
- SDS
Melting point | 213 °C (decomp) |
---|---|
Boiling point | 365.61°C (rough estimate) |
Density | 1.2995 (rough estimate) |
refractive index | 1.6620 (estimate) |
storage temp. | 2-8°C |
solubility | DMF: 0.5 mg/ml; DMSO: 1 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): 0.5 mg/ml |
form | A crystalline solid |
pka | 2.16±0.23(Predicted) |
color | Light yellow to yellow |
Stability | Hygroscopic |
FDA UNII | 27723548JL |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
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2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | H1771 | 3-Hydroxy-DL-kynurenine | 484-78-6 | 25mg | $167 | 2024-03-01 | Buy |
Sigma-Aldrich | H1771 | 3-Hydroxy-DL-kynurenine | 484-78-6 | 100mg | $499 | 2024-03-01 | Buy |
Sigma-Aldrich | 78047 | 3-Hydroxy-DL-kynurenine analyticalstandard | 484-78-6 | 10MG | $127 | 2024-03-01 | Buy |
Sigma-Aldrich | 78047 | 3-Hydroxy-DL-kynurenine analyticalstandard | 484-78-6 | 50MG | $339 | 2022-05-15 | Buy |
Cayman Chemical | 27778 | 3-hydroxy-DL-Kynurenine | 484-78-6 | 10mg | $68 | 2024-03-01 | Buy |
2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Chemical Properties,Uses,Production
Uses
3-Hydroxy-DL-kynurenine is a tryptophan metabolite. Could be associated with symptoms in Parkinson''s disease.
Uses
3-Hydroxykynurenine is a metabolite of tryptophan. ential endogenous neurotoxin.
Uses
3-Hydroxy-DL-kynurenine has been used:
- as a substrate for the recombinant human kynureninase assay
- as a reference standard in tandem mass spectrometry (MS/MS) analysis
- as a control for quantifying serum 3-Hydroxy-DL-kynurenine levels in diabetic retinopathy patients
Definition
ChEBI: A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.
General Description
3-Hydroxy-DL-kynurenine is a tryptophan metabolite with a molecular weight corresponding to 224Da. It is a chromophore or hydrophilic yellow compound present in the lens of the eye. 3-Hydroxy-DL-kynurenine is synthesized from kynurenine?by the action of enzyme kynurenine 3-monooxygenase (KMO). It is metabolized to 3-hydroxyanthranilic acid and xanthurenic acid in the presence of enzymes kynureninase and kynurenine aminotransferases, respectively.
Biochem/physiol Actions
3-Hydroxy-DL-kynurenine (3-HKYN) has antioxidant functionality and prevents lipid peroxidation in cerebral cortex. It may modulate synaptic neurotransmission. The levels of 3-HKYN is elevated in Huntington′s disease. However, its role in neurodegenerative diseases is still not understood well. Kynurenine metabolism is linked with glutamatergic neurotransmission and the level of 3-HKYN is linked to the pathophysiology of schizophrenia.
2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9407 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94658 | 76 |
Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42959 | 64 |
Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27314 | 60 |
Aikon International Limited | 025-58859352 18068836627 | sales01@aikonchem.com | China | 15085 | 58 |
View Lastest Price from 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2022-09-09 | 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid
484-78-6
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
- 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid
484-78-6
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.