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ChemicalBook >> CAS DataBase List >>2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid Structure
2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid structure
CAS No.
331741-94-7
Chemical Name:
2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid
Synonyms
Pargluva;BMS 298585;Muraglitazar;Amylin (8-37), amide;amylin pharmaceuticals;muraglitazar(BMS-298585);symlinDiabetes Associated Peptide (8-37), amide;N-((4-Methoxyphenoxy)carbonyl)-N-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)glycine;2-(((4-Methoxyphenoxy)carbonyl)(4-(2-(5-Methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)aMino)acetic acid;N-[(4-Methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine
CBNumber:
CB61261075
Molecular Formula:
C29H28N2O7
Molecular Weight:
516.54
MDL Number:
MFCD20270627
MOL File:
331741-94-7.mol
MSDS File:
SDS
Last updated:2024-11-19 15:53:33
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2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid Properties

Melting point 123-125°C
Boiling point 736.4±70.0 °C(Predicted)
Density 1.274±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility Chloroform (Slightly), Methanol (Slightly)
pka 3.82±0.10(Predicted)
form Solid
color Off-White
FDA UNII W1MKM70WQI
EPA Substance Registry System Glycine, N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]- (331741-94-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335-H402
Precautionary statements  P261-P264-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10007853 Muraglitazar ≥98% 331741-94-7 1mg $341 2024-03-01 Buy
TRC M796500 Muraglitazar 331741-94-7 2mg $320 2021-12-16 Buy
American Custom Chemicals Corporation API0006317 MURAGLITAZAR 95.00% 331741-94-7 1MG $315 2021-12-16 Buy
ApexBio Technology C3986 Muraglitazar 331741-94-7 1mg $389 2021-12-16 Buy
AK Scientific 2859CB Muraglitazar 331741-94-7 1mg $478 2021-12-16 Buy
Product number Packaging Price Buy
10007853 1mg $341 Buy
M796500 2mg $320 Buy
API0006317 1MG $315 Buy
C3986 1mg $389 Buy
2859CB 1mg $478 Buy

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid Chemical Properties,Uses,Production

Description

Muraglitazar is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ (EC50s = 0.32 and 0.11 μM, respectively). It is selective for PPARα/γ over other nuclear receptors, including PPARδ, RXRα, RARs, estrogen receptor α (ERα), ERβ, androgen receptor (AR), and progesterone receptor (PR). Muraglitazar (50 μM) reduces the size of lipid droplets in oleic acid-treated HepaRG human hepatocytes. It reduces plasma levels of glucose, triglycerides, free fatty acids, and insulin by 54, 33, 62, and 48%, respectively, in db/db mice when administered at a dose of 10 mg/kg per day. Muraglitazar (10 mg/kg per day) reduces plasma levels of glucose, triglycerides, and cholesterol in diet-induced obese mice. Muraglitazar also inhibits LPS-induced increases in nitric oxide (NO) production and IL-6, TNF-α, and inducible nitric oxide synthase (iNOS) protein levels in J774 murine macrophages in a concentration-dependent manner. It inhibits carrageenan-induced paw edema in mice when administered at doses ranging from 12.5 to 50 mg/kg.

Chemical Properties

Off-White Solid

Uses

It is a peroxisome proliferator-activated receptor (PPAR) a/ dual agonist

Uses

It is a peroxisome proliferator-activated receptor (PPAR) α/γ dual agonist.

Definition

ChEBI: Muraglitazar is a member of 1,3-oxazoles.

in vitro

in murine j774 macrophages, muraglitazar dose-dependently reduced lipopolysaccharide-induced inducible nitric oxide synthase (inos) expression, nitrous oxide, il-6 and tnfα production and showed no effect on cell viability at the given concentration. muraglitazar decreased the levels of inos mrna expression, suggesting that the suppressive effect of muraglitazar was mediated at the level of inos transcription. in human hek293 cells, muraglitazar did not affect the nuclear levels of nf- κb p65 compared to the control and did not modulate nf-κb-mediated transcription [1].

in vivo

male charles river mice were administrated orally with muraglitazar at a dose of 12.5, 25, 50 mg/kg for six hours. muraglitazar, in a dose-dependent fashion, prevented the development of oedema. in addition, muraglitazar dose-dependently attenuated inflammation and decreased the levels of il-6, tnfα and inos mrna [1].

IC 50

0.42 μm: shows agonistic activity at peroxisome proliferator-activated receptor α (pparα)

References

[1]. paukkeri, e., leppnen, t., lindholm, m., yam, m., asmawi, m., & kolmonen, a. et al. anti-inflammatory properties of a dual ppargamma/alpha agonist muraglitazar in in vitro and in vivo models. arthritis research & therapy. 2013;15(2): r51.

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid Suppliers

Global( 52)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2123 70
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32321 50
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 meilunui@163.com China 4727 58
China Kouting Group Limited +86 (21) 5811-6473 5811-6475 sales@koutingchina.com China 496 60
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632 sales@reading-chemicals.com China 15178 58
Tianjin Anhao Biological Technology Co., Ltd. sales@ahpharmatech.com China 5734 55
Supplier Advantage
TargetMol Chemicals Inc. 		58
InvivoChem 		58
Aladdin Scientific 		58
J & K SCIENTIFIC LTD. 76
LGM Pharma 70
Chemsky（shanghai）International Co.,Ltd. 50
Dalian Meilun Biotech Co., Ltd. 58
China Kouting Group Limited 60
Wuxi Zhongkun Biochemical Technology Co., Ltd. 58
Tianjin Anhao Biological Technology Co., Ltd. 55

View Lastest Price from 2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Muraglitazar pictures 2024-11-19 Muraglitazar
331741-94-7
 US $293.00-987.00 / mg 99.31% 10g TargetMol Chemicals Inc.
  • Muraglitazar pictures
  • Muraglitazar
    331741-94-7
  • US $293.00-987.00 / mg
  • 99.31%
  • TargetMol Chemicals Inc.

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid Spectrum

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid(331741-94-7)1HNMR

331741-94-7(2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid)Related Search:

2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid CHEMBRDG-BB 7017116
N-[(4-Methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine Pargluva 2-(((4-Methoxyphenoxy)carbonyl)(4-(2-(5-Methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)aMino)acetic acid 2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid BMS 298585 Muraglitazar Amylin (8-37), amide AMYLIN (8-37), AMIDE; AMYLIN PHARMACEUTICALS; MURAGLITAZAR; OXYNTOMODULIN; SYMLINDIABETES ASSOCIATED PEPTIDE (8-37), AMIDE amylin pharmaceuticals symlinDiabetes Associated Peptide (8-37), amide Glycine, N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]- muraglitazar(BMS-298585) N-((4-Methoxyphenoxy)carbonyl)-N-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)glycine 331741-94-7 C29H28N2O7 Agro Products Agonist Intermediates & Fine Chemicals Pharmaceuticals