KF 17837
- CAS No.
- 152881-18-0
- Chemical Name:
- KF 17837
- Synonyms
- KF 17837;KF 17837S;8-(3,4-Dimethoxyphenyl)-7-methyl-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione;1H-Purine-2,6-dione,8-(3,4-diMethoxyphenyl)-3,7-dihydro-7-Methyl-1,3-dipropyl
- CBNumber:
- CB61310209
- Molecular Formula:
- C20H26N4O4
- Molecular Weight:
- 386.44
- MDL Number:
- MFCD22493499
- MOL File:
- 152881-18-0.mol
KF 17837 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 095548 | 8-(3,4-Dimethoxyphenyl)-7-methyl-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione 95+% | 152881-18-0 | 250mg | $742 | 2021-12-16 | Buy |
| Matrix Scientific | 095548 | 8-(3,4-Dimethoxyphenyl)-7-methyl-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione 95+% | 152881-18-0 | 1g | $1647 | 2021-12-16 | Buy |
| AK Scientific | 7673AA | 8-(3,4-Dimethoxyphenyl)-7-methyl-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione | 152881-18-0 | 1g | $2273 | 2021-12-16 | Buy |
KF 17837 Chemical Properties,Uses,Production
Description
KF 17837S is an adenosine A(2a) receptor antagonists, which is potential therapeutic and neuroprotective effects in Parkinson's disease.
in vitro
The novel A2A receptor antagonist, (E)-8-(3,4-dimethoxystyryl)-1,3-dipropyl-7-methylxanthine (KF 17837), blocked the CGS 21680 (1 nM)-induced inhibition of [3H]-GABA efflux with an EC50 of approximately 30 nM and also antagonized the CGS 21680 (0.1 nM)-induced stimulation of [3H]-ACh release with an EC50 of approximately 0.3 nM._x000D_ _x000D_ Reference: Br J Pharmacol. 1994 Sep;113(1):43-8. https://pubmed.ncbi.nlm.nih.gov/7812630/
in vivo
Autoradiographic study of [3H]KF17837S binding using rat brain sections revealed that the binding site was highly enriched in the striatal region. These data indicate that [3H] KF17837S labels the adenosine A2A receptor in rat brain._x000D_ _x000D_ Reference: Mol Pharmacol. 1994 Nov;46(5):817-22. https://pubmed.ncbi.nlm.nih.gov/7969067/
target
KF 17837S is an adenosine A(2a) receptor antagonists.
KF 17837 Preparation Products And Raw materials
Raw materials
Preparation Products
KF 17837 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32038 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19863 | 58 |
| Beijing Yisiyan Technology Research Center | 010-56645598 13366904824 | bjkaida@163.com | China | 1637 | 59 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1248 | 58 |
| chemfish tokyo co.,ltd | 0731-85567275 18229978283 | tokyo@chemfish.com | China | 2785 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19711 | 58 |
