INDEX NAME NOT YET ASSIGNED
- CAS No.
- 2851820-52-3
- Chemical Name:
- INDEX NAME NOT YET ASSIGNED
- Synonyms
- Benzonitrile, 3-[[3,4-dioxo-2-[[trans-4-[4-(trifluoromethyl)phenoxy]cyclohexyl]amino]-1-cyclobuten-1-yl]amino]-5-(trifluoromethyl)-
- CBNumber:
- CB613201760
- Molecular Formula:
- C25H19F6N3O3
- Molecular Weight:
- 523.43
- MDL Number:
- MOL File:
- 2851820-52-3.mol
INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production
Uses
EIF2α activator 1 (Compound 40) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 1 increases the expression level of eIF2α downstream proteins, ATF and CHOP. EIF2α activator 1 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.00 and 19.3 μM, respectively[1].
IC 50
eIF2
References
[1] Jinsook Kwak, et al. A bioisosteric approach to the discovery of novel N-aryl-N'-[4-(aryloxy)cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. Eur J Med Chem. 2022 May 29;239:114501. DOI:10.1016/j.ejmech.2022.114501
INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials
Raw materials
Preparation Products
INDEX NAME NOT YET ASSIGNED Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6345 | 55 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Hubei wei shi reagent group ltd., company | 027-59101766 13125137661 | 2853877621@qq.com | China | 7979 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19727 | 58 |