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Thymidine

Thymidine Structure
Thymidine structure
CAS No.
50-89-5
Chemical Name:
Thymidine
Synonyms
DT;1-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione;Deoxythymidine;β-Thymidine;b-Thymidine;Thymidin;Deoxyribothymidine;-Methylvalerophenone;THYMINE-2-DEOXYRIBOSIDE;Tyrosinase-related protein 2
CBNumber:
CB6134417
Molecular Formula:
C10H14N2O5
Molecular Weight:
242.23
MDL Number:
MFCD00006537
MOL File:
50-89-5.mol
MSDS File:
SDS
Last updated:2024-11-19 20:33:22
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Thymidine Properties

Melting point 186-188 °C(lit.)
Boiling point 385.05°C (rough estimate)
alpha 18.6 º (c=3, H2O)
Density 1.3129 (rough estimate)
refractive index 33 ° (C=1, 1mol/L NaOH)
storage temp. 2-8°C
solubility Acetone, DMSO (Slightly), Ethanol, Ethyl Acetate, Methanol (Slightly, Heated), P
pka pK1:9.79;pK2:12.85 (25°C)
form Crystalline Powder
color White to almost white
PH 9.8
optical activity [α]20/D +19±1°, c = 1% in H2O
Water Solubility SOLUBLE
λmax 267 (pH 7)；267 (pH 13)
Merck 14,9397
BRN 89285
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey IQFYYKKMVGJFEH-XLPZGREQSA-N
LogP -0.930
CAS DataBase Reference 50-89-5(CAS DataBase Reference)
EWG's Food Scores 1
NCI Dictionary of Cancer Terms thymidine
FDA UNII VC2W18DGKR
NCI Drug Dictionary thymidine
NIST Chemistry Reference Thymidine(50-89-5)
EPA Substance Registry System Thymidine (50-89-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
Hazard Codes  Xi
Risk Statements  20/21/22-40-36/37/38-68
Safety Statements  22-24/25-37/39-26-36/37/39
WGK Germany  3
RTECS  XP2071000
F  10
TSCA  Yes
HS Code  29335990
NFPA 704
1
2 0

Thymidine price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 89270 Thymidine ≥99.0% (HPLC) 50-89-5 1g $57.4 2024-03-01 Buy
Sigma-Aldrich PHR3163 Zidovudine Related Compound D pharmaceutical secondary standard 50-89-5 100MG $534 2024-03-01 Buy
Sigma-Aldrich 6060 Thymidine - CAS 50-89-5 - Calbiochem 50-89-5 5G $82.3 2024-03-01 Buy
Sigma-Aldrich 1724543 Zidovudine Related Compound D United States Pharmacopeia (USP) Reference Standard 50-89-5 50mg $1180 2024-03-01 Buy
TCI Chemical T0233 Thymidine >98.0%(HPLC)(T) 50-89-5 1g $31 2024-03-01 Buy
Product number Packaging Price Buy
89270 1g $57.4 Buy
PHR3163 100MG $534 Buy
6060 5G $82.3 Buy
1724543 50mg $1180 Buy
T0233 1g $31 Buy

Thymidine Chemical Properties,Uses,Production

Description

Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix. In cell biology it is used to synchronize the cells in G1/early S phase.

Chemical Properties

White needle crystal, soluble in methanol, ethanol, DMSO and other organic solvents.

Physical properties

Thymidine can exist in vitro conditions as a solid (as white crystals or as white crystalline powder). Under standard temperature and pressure, the stability of this compound is very high. As a part of DNA structure, thymidine occurs in living organisms (also in DNA viruses). Therefore, it is a non-toxic compound. In RNA, there is uridine instead of thymidine. Uridine is formed from the combination of uracil with ribose sugar. The key difference between thymine and thymidine is that thymine is a nucleobase, whereas thymidine is a nucleoside.

Uses

Constituent of deoxyribonucleic acid. The nucleoside (deoxyriboside) of thymine. Occurs in DNA. It is a nucleoside consisting of one thymine molecule linked to ad-doxyribose sugar molecule.

Uses

Thymidine is used in the syntheses of active pharmaceutical ingredient such as zidovudine. It also pairs with deoxyadenosine in double-stranded deoxyribonucleic acid. It is used to synchronize the cells in G1/early S phase in cell biology.

Definition

The NUCLEOSIDE formed when thymine is linked to D-ribose by a β-glycosidic bond.

Definition

ChEBI: Thymidine is a pyrimidine 2'-deoxyribonucleoside having thymine as the nucleobase. It has a role as a metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a thymine. It is an enantiomer of a telbivudine.

General Description

Thymidine is also referred to as pyrimidine deoxynucleoside. Deoxythymidine is a nucleoside present in DNA. In a DNA double stranded structure, thymidine pairs with deoxyadeninosine.

Biochem/physiol Actions

Thymidine is useful in cell synchronization during S-phase. In the salvage pathway of pyrimidines, pyrimidine phosphorylase reversibly converts thymine to thymidine.

Mechanism of action

High concentrations of thymidine interrupt the deoxynucleotide metabolism pathway through competitive inhibition, thus blocking DNA replication. A single treatment with thymidine arrests cells throughout S phase, so a double treatment acts to induce a more uniform block in early S phase.

Safety Profile

Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise -thymidine from ethyl acetate, MeOH/Et2O (m 188o) or H2O (as 2H2O m 189o). It is soluble in water and hot organic solvents. The picrate has m 230o (from EtOH).

Thymidine synthesis

40615-39-2
50-89-5
Synthesis of Thymidine from 5'-O-Dimethoxytrityl-deoxythymidine

Thymidine Preparation Products And Raw materials

Raw materials

Preparation Products

Zidovudine Stavudine 5-METHYLCYTOSINE 5'-O-(4,4'-DIMETHOXYTRITYL)-N4-BENZOYL-5-METHYL-2'-DEOXYCYTIDINE 3',5'-DIACETYLTHYMIDINE

Thymidine Suppliers

Global( 737)Suppliers
Supplier Tel Email Country ProdList Advantage
Yunbio Tech Co.,Ltd.
+86-010-60605551 +86-18046518538 yunbiochem@126.com China 321 58
Wuhu Nuowei chemistry Co., Ltd.
+86-0553-2911116-802 +undefined17756524438 sales1@nuowei-chem.com China 1638 58
SHANGHAI NOVRIBO BIOTECH
17821030819 June.Liu@Desano.com China 73 58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd
027-88013699 17354350817 Ryan@jiutian-bio.com China 6001 58
Xinxiang Aurora Biotechnology Co.,Ltd.
+86-0086-0373-3088722 +8618637352520 info@aurora-biotech.com China 93 58
Hebei Weibang Biotechnology Co., Ltd 		+8615531157085 abby@weibangbio.com China 8812 58
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12840 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5893 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18779 58
Supplier Advantage
Yunbio Tech Co.,Ltd.
58
Wuhu Nuowei chemistry Co., Ltd.
58
SHANGHAI NOVRIBO BIOTECH
58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd
58
Xinxiang Aurora Biotechnology Co.,Ltd.
58
Hebei Weibang Biotechnology Co., Ltd 		58
Hebei Mojin Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58

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View Lastest Price from Thymidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Thymidine pictures 2024-11-22 Thymidine
50-89-5
 US $0.00-0.00 / Kg/Drum 1KG 99.0%min 1000KGS WUHAN FORTUNA CHEMICAL CO., LTD
Thymidine pictures 2024-11-19 Thymidine
50-89-5
 US $45.00 / mg ≥98% 10g TargetMol Chemicals Inc.
Thymidine pictures 2024-11-14 Thymidine
50-89-5
 US $0.00 / KG 1KG 99% 100 MT Hebei Weibang Biotechnology Co., Ltd
  • Thymidine pictures
  • Thymidine
    50-89-5
  • US $0.00-0.00 / Kg/Drum
  • 99.0%min
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Thymidine pictures
  • Thymidine
    50-89-5
  • US $45.00 / mg
  • ≥98%
  • TargetMol Chemicals Inc.
  • Thymidine pictures
  • Thymidine
    50-89-5
  • US $0.00 / KG
  • 99%
  • Hebei Weibang Biotechnology Co., Ltd

Thymidine Spectrum

Thymidine(50-89-5)MSThymidine(50-89-5)1HNMRThymidine(50-89-5)13CNMRThymidine(50-89-5)IR1Thymidine(50-89-5)IR2Thymidine(50-89-5)Raman

50-89-5(Thymidine)Related Search:

Starch soluble Thymine 5-HYDROXYMETHYL-2'-DEOXYURIDINE T-SUCCINATE5'-O-DMTR-THYMIDINE-SUCCINATE 5’-o-[bis(4-methoxyphenyl)phenylmethyl]-thymidi
THYMIDINE 5'-TRIPHOSPHATE SODIUM SALT,THYMIDINE-5'-TRIPHOSPHATE TETRASODIUM SALT,THYMIDINE-5'-TRIPHOSPHATE TRISODIUM SALT 3’-azido-3’-deoxy-thymidi Trifluridine DMT-dT Phosphoramidite 5-Methyluridine
5’-o-(triphenylmethyl)-thymidi Thymidine-5'-monophosphate disodium salt 3’-deoxy-thymidi Deoxythymidine triphosphate 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione
3’-deoxy-3’-fluoro-thymidi 2’,3’-didehydro-3’-deoxy-thymidi THYMIDINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT

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