ChemicalBook >> CAS DataBase List >>2,2-Dimethylthiopropionamide
2,2-Dimethylthiopropionamide
- CAS No.
- 630-22-8
- Chemical Name:
- 2,2-Dimethylthiopropionamide
- Synonyms
- NSC 381432;Thiopivalamide;Neopentanethioamide;2,2-Trimethylthioacetamide;2,2-DIMETHYLTHIOPROPIOMIDE;2,2-DIMETHYLTHIOPROPIONAMIDE;2,2,2-Trimethylthioacetamide,;2,2,2-Dimethylthiopropionamide;Propanethioamide, 2,2-dimethyl-
- CBNumber:
- CB61449866
- Molecular Formula:
- C5H11NS
- Molecular Weight:
- 117.21
- MDL Number:
- MFCD09742834
- MOL File:
- 630-22-8.mol
- MSDS File:
- SDS
Last updated:2024-07-29 17:07:33
| Melting point | 117-119℃ (ethyl acetate hexane ) |
|---|---|
| Boiling point | 162.1±23.0℃ (760 Torr) |
| Density | 0.978±0.06 g/cm3 (20 ºC 760 Torr) |
| Flash point | 51.9±22.6℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Ethyl Acetate |
| form | Solid |
| pka | 13.33±0.29(Predicted) |
| color | White |
| Water Solubility | Soluble in water (10 g/L) (25°C). |
| InChI | InChI=1S/C5H11NS/c1-5(2,3)4(6)7/h1-3H3,(H2,6,7) |
| InChIKey | FJZJUSOFGBXHCV-UHFFFAOYSA-N |
| SMILES | C(N)(=S)C(C)(C)C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312a-P330-P501a | |||||||||
| HS Code | 2930909899 | |||||||||
| NFPA 704 |
|
2,2-Dimethylthiopropionamide price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | H32092 | 2,2,2-Trimethylthioacetamide, 97% | 630-22-8 | 1g | $53.65 | 2024-03-01 | Buy |
| Alfa Aesar | H32092 | 2,2,2-Trimethylthioacetamide, 97% | 630-22-8 | 10g | $315.65 | 2024-03-01 | Buy |
| TRC | T796135 | 2,2-Dimethylthiopropionamide | 630-22-8 | 1g | $50 | 2021-12-16 | Buy |
| AK Scientific | 9562AB | 2,2,2-Trimethylthioacetamide | 630-22-8 | 1g | $38 | 2021-12-16 | Buy |
| AK Scientific | J99033 | 2,2,2-Trimethylthioacetamide | 630-22-8 | 5g | $88 | 2021-12-16 | Buy |
2,2-Dimethylthiopropionamide Chemical Properties,Uses,Production
Uses
2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).
Synthesis
To a round bottom flask (250 mL) was added trimethyl amine (5.0 g, 0.049 mol) and Lawesson's reagent (8.0g, 0.020 mol), dissolved in THF (100 mL), nitrogen, 80° C oil. The reaction bath for 4 hours. TLC monitors the reaction progress. After completion of the reaction, the solvent was removed by rotary evaporation; the residue was purified by silica gel column chromatography (petroleum ether: 1: ethyl acetate = 10) to give a white solid 2,2-Dimethylthiopropionamide (3.7 g, 65percent yield).
2,2-Dimethylthiopropionamide Preparation Products And Raw materials
Global( 149)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Enki Biopharmaceuticals (Shanghai) Limited | +86-0086-2157680326 +8613916707528 | yusu@enkibiopharma.com | China | 46 | 58 |
| Zison Pharmaceutical (Shandong) Co., Ltd. | +86-0086-531-88259693 +86-18660188356 | tracy.li@zisonpharm.com | China | 57 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12840 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5978 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10986 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20287 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18747 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32951 | 60 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 340 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
View Lastest Price from 2,2-Dimethylthiopropionamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-14 | 2,2-Dimethylthiopropionamide
630-22-8
|
US $0.00-0.00 / kg | 1kg | 98%min | 10mt | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-11-11 | 2,2-Dimethylpropanethioamide
630-22-8
|
US $0.00-0.00 / kg | 1kg | 99.0% | 20000 | Enki Biopharmaceuticals (Shanghai) Limited | |
 |
2024-09-23 | 2,2-Dimethylthiopropionamide
630-22-8
|
US $0.00 / kg | 0.1kg | 99.9% | 40-80kgs | Zison Pharmaceutical (Shandong) Co., Ltd. |
-
- 2,2-Dimethylthiopropionamide
630-22-8
- US $0.00-0.00 / kg
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2,2-Dimethylpropanethioamide
630-22-8
- US $0.00-0.00 / kg
- 99.0%
- Enki Biopharmaceuticals (Shanghai) Limited
-
- 2,2-Dimethylthiopropionamide
630-22-8
- US $0.00 / kg
- 99.9%
- Zison Pharmaceutical (Shandong) Co., Ltd.
630-22-8(2,2-Dimethylthiopropionamide)Related Search:
2,2-DIMETHYLTHIOPROPIONAMIDE
2,2,2-Trimethylthioacetamide,
Neopentanethioamide
NSC 381432
Thiopivalamide
2,2-DIMETHYLTHIOPROPIOMIDE
2,2,2-Dimethylthiopropionamide
Propanethioamide, 2,2-dimethyl-
2,2-Trimethylthioacetamide
630-22-8