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ChemicalBook >> CAS DataBase List >>4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Structure
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid structure
CAS No.
641569-94-0
Chemical Name:
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
Synonyms
-3-((4-(pyridin-3-yL;Nilotinib Intemediate 2;Nilotinib EP Impurity D;Nilotinib EP Impurity D/B;4-Methyl-3-((4-(pyridin-3-yl);Nilotinib Carboxylic Acid Impurity;Nilotinib Impurity 6 (Nilotinib EP Impurity D);Nilotinib Hydrochloride Monohydrate EP Impurity D;4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzoicaci;4-Methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoicacid
CBNumber:
CB61503982
Molecular Formula:
C17H14N4O2
Molecular Weight:
306.32
MDL Number:
MFCD11521324
MOL File:
641569-94-0.mol
MSDS File:
SDS
Last updated:2024-11-13 11:39:26
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4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Properties

Melting point >257oC (dec.)
Boiling point 587.9±60.0 °C(Predicted)
Density 1.336
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility DMSO (Slightly), Methanol (Slightly, Heated)
pka 4.35±0.10(Predicted)
form Solid
color Pale Beige
Stability Hygroscopic
InChI InChI=1S/C17H14N4O2/c1-11-4-5-12(16(22)23)9-15(11)21-17-19-8-6-14(20-17)13-3-2-7-18-10-13/h2-10H,1H3,(H,22,23)(H,19,20,21)
InChIKey LDLZPHLSVKGFSC-UHFFFAOYSA-N
SMILES C(O)(=O)C1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1
CAS DataBase Reference 641569-94-0(CAS DataBase Reference)
FDA UNII TQ9WCS4PF0

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P271-P280
HS Code  2933599590

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC N465305 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoicacid 641569-94-0 5g $275 2021-12-16 Buy
SynQuest Laboratories 4H21-1-Y0 4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid 641569-94-0 1g $133 2021-12-16 Buy
Apolloscientific OR16087 4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoicacid 641569-94-0 250mg $15 2021-12-16 Buy
Apolloscientific OR16087 4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoicacid 641569-94-0 1g $19 2021-12-16 Buy
AK Scientific J11466 NilotinibImpurity20 641569-94-0 25mg $39 2021-12-16 Buy
Product number Packaging Price Buy
N465305 5g $275 Buy
4H21-1-Y0 1g $133 Buy
OR16087 250mg $15 Buy
OR16087 1g $19 Buy
J11466 25mg $39 Buy

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Chemical Properties,Uses,Production

Uses

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is used in the preparation of (pyridinyl)-N-[(triazolyl)phenyl]pyrimidinamine derivatives and (pyridinyl)-N-[oxadiazolyl)phenyl]pyrimidinamine derivatives, and can be used in the detection of their activity as antileukemia agents (neoplastic stem cell leukemia). 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is also a Nilotinib (N465300) intermediate, which might be useful in treatment of chronic myelogenous leukemia.

Synthesis

3- [(Aminoiminomethyl)amino] -4-methyl-benzoic acid methyl ester mononitrate (10 g),3-(Dimethylamino)-1-(pyridine-3-yl)prop-2-en-1-one (7.3 g), sodium hydroxide (1.7 g) was added to 1-butanol (100 mL) in a round bottom flask under nitrogen atmosphere. The reaction mass was heated to reflux temperature and stirred for 12 hours. Then the reaction mass was cooled to 25-35°C, and iN sodium hydroxide solution (1.5 g in 37 mL of DM water) was added to it throughout 20 mm. The reaction mass was heated to reflux temperature (120-125°C) and then cooled to 25-35°C. Hydrochloric acid was added to the reaction mass at 25-35°C and stirred for an hour. The material formed was filtered, washed with DM water and then dried under vacuum at 50-55°C to provide 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid (8.7 g).

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid synthesis

2458-12-0
641569-94-0
Synthesis of 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid from 3-Amino-4-methylbenzoic acid

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Preparation Products And Raw materials

Raw materials

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester Methyl 3-guanidino-4-Methylbenzoate Imatinib Impurity Methyl 3-amino-4-methylbenzoate 3-Amino-4-methylbenzoic acid
3-[(aMinoiMinoMethyl)aMino]-4-Methylbenzoic acid Methyl ester Mononitrate 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid methyl ester 3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate Ethyl 3-Amino-4-methylbenzoate 3-Acetylpyridine
3-Bromo-4-methylbenzoic acid

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Preparation Products

Nilotinib

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Suppliers

Global( 268)Suppliers
Supplier Tel Email Country ProdList Advantage
Yangzhou Qinyuan Pharmatech Co.,ltd 		+86-18752526868 jennysun@yzqyyykj.com China 81 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20235 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 +86-16264648883 niki@zlchemi.com China 7245 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29730 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21628 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
Anqing Chico Pharmaceutical Co., Ltd. 		15380796838 chloewu@chicopharm.cn CHINA 340 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29858 58
Supplier Advantage
Yangzhou Qinyuan Pharmatech Co.,ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co Ltd 		58
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
Shanghai Yingrui Biopharma Co., Ltd. 		60
Anqing Chico Pharmaceutical Co., Ltd. 		58
career henan chemical co 		58

View Lastest Price from 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid pictures 2025-04-25 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
641569-94-0
 US $150.00 / kg 1kg 99% 500kg Hebei Zhuanglai Chemical Trading Co Ltd
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid pictures 2024-11-26 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
641569-94-0
 US $0.00-0.00 / kg 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid pictures 2024-10-31 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
641569-94-0
 US $0.00 / g 10g 99% 10tons Yangzhou Qinyuan Pharmatech Co.,ltd

641569-94-0(4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid)Related Search:

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4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid Benzoic acid, 4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]- 4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidiny]aMino]benzoic acid 2-[(5-Carboxy-2-methylphenyl)amino]-4-(pyridin-3-yl)pyrimidine, 3-{2-[(5-Carboxy-2-methylphenyl)amino]pyrimidin-4-yl}pyridine Nilotinib Intemediate 2 4-Methyl-3-((4-(pyridin-3-yl) Nilotinib EP Impurity D Nilotinib Carboxylic Acid Impurity -3-((4-(pyridin-3-yL 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid(For export only) Nilotinib EP Impurity D/B 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic aci... 3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylbenzoic acid 4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzoicaci Nilotinib Impurity 6 (Nilotinib EP Impurity D) Nilotinib Hydrochloride Monohydrate EP Impurity D 4-Methyl-3-[[4-G-pyridinyl)-2-pyrimidinyl]amino] benzoic acid 4-Methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoicacid 641569-94-0 641589-94-0