cis-4-Hydroxy-L-proline
- CAS No.
- 618-27-9
- Chemical Name:
- cis-4-Hydroxy-L-proline
- Synonyms
- (2S,4S)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;H-CIS-HYP-OH;CIS-4-HYDROXYPROLINE;CIS-HYP-OH;cis-Hydroxy-L-proline;(4S)-4-hydroxypyrrolidine-2-carboxylic acid;CHYP;cis L;cis-L-Hyp-OH;H-L-CIS-HYP-OH
- CBNumber:
- CB6158895
- Molecular Formula:
- C5H9NO3
- Molecular Weight:
- 131.13
- MDL Number:
- MFCD00064319
- MOL File:
- 618-27-9.mol
- MSDS File:
- SDS
Melting point | 257 °C (dec.) (lit.) |
---|---|
alpha | -59 º (c=2, H2O) |
Boiling point | 242.42°C (rough estimate) |
Density | 1.3121 (rough estimate) |
refractive index | -59 ° (C=2, H2O) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | soluble |
form | Powder |
pka | 2.14±0.40(Predicted) |
color | White to beige |
Water Solubility | soluble |
Merck | 14,4840 |
BRN | 81440 |
InChIKey | PMMYEEVYMWASQN-IMJSIDKUSA-N |
CAS DataBase Reference | 618-27-9(CAS DataBase Reference) |
FDA UNII | 43V78B6A3B |
EPA Substance Registry System | L-Proline, 4-hydroxy-, (4S)- (618-27-9) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 24/25-36/37/39-27-26 | |||||||||
WGK Germany | 3 | |||||||||
F | 10 | |||||||||
TSCA | Yes | |||||||||
HS Code | 29339900 | |||||||||
NFPA 704 |
|
cis-4-Hydroxy-L-proline price More Price(50)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | H1637 | cis-4-Hydroxy-L-proline collagen synthesis inhibitor | 618-27-9 | 50mg | $79.9 | 2024-03-01 | Buy |
Sigma-Aldrich | H1637 | cis-4-Hydroxy-L-proline collagen synthesis inhibitor | 618-27-9 | 1g | $1050 | 2024-03-01 | Buy |
TCI Chemical | H1169 | cis-4-Hydroxy-L-proline >97.0%(T) | 618-27-9 | 100mg | $68 | 2024-03-01 | Buy |
TCI Chemical | H1169 | cis-4-Hydroxy-L-proline >97.0%(T) | 618-27-9 | 1g | $327 | 2024-03-01 | Buy |
Alfa Aesar | H27194 | cis-4-Hydroxy-L-proline, 99% | 618-27-9 | 250mg | $162.65 | 2024-03-01 | Buy |
cis-4-Hydroxy-L-proline Chemical Properties,Uses,Production
Chemical Properties
White to beige powder
Uses
cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line and rat pancreatic carcinoma cell line DSL6A.
Uses
cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line3 and rat pancreatic carcinoma cell line DSL6A. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.
Uses
Hydroxyprolines are valuable chiral building blocks for organic synthesis of pharmaceuticals. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.
Definition
ChEBI: L-Proline in which a hydrogen at the 4-position of the pyrrolidine ring is substituted by a hydroxy group (S-configuration).
Biochem/physiol Actions
cis-4-Hydroxy-L-proline (CHP) and its derivatives may have anticancer activity. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.
cis-4-Hydroxy-L-proline Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 724 | 55 | |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7621 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19343 | 58 |
Chengdu Pukang Biotechnology Co., Ltd | 028-82550498 | export@pu-kang.com | CHINA | 210 | 58 |
Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2169 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
View Lastest Price from cis-4-Hydroxy-L-proline manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2023-11-25 | cis-4-Hydroxy-L-proline
618-27-9
|
US $0.00-0.00 / kg | 1kg | 99% | 500000kg | Hebei Kingfiner Technology Development Co.Ltd | |
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2022-10-01 | cis-4-Hydroxy-L-proline
618-27-9
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
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2022-02-22 | (2S,4S)-(-)-4-Hydroxy-2-pyrrolinecarboxylic acid
618-27-9
|
US $0.00 / KG | 1KG | 97.9% | 100 tons | Honest Joy Holdings Limited
|
-
- cis-4-Hydroxy-L-proline
618-27-9
- US $0.00-0.00 / kg
- 99%
- Hebei Kingfiner Technology Development Co.Ltd
-
- cis-4-Hydroxy-L-proline
618-27-9
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- (2S,4S)-(-)-4-Hydroxy-2-pyrrolinecarboxylic acid
618-27-9
- US $0.00 / KG
- 97.9%
- Honest Joy Holdings Limited
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