NARINGENIN CHALCONE
- CAS No.
- 73692-50-9
- Chemical Name:
- NARINGENIN CHALCONE
- Synonyms
- C06561;ISOSALIPURPOL;Naringein chalcone;NARINGENIN CHALCONE;(E)-Naringenin chalcone;2',4',6',4-TETRAHYDROXYCHALCONE;4,2',4',6'-Tetrahydroxychalcone;trans-2'4'6'4-tetrahydroxychalcone;Naringenin Chalcone(cis and trans mix);NARINGENIN CHALCONE(cis and trans Mix)(RG)
- CBNumber:
- CB6171155
- Molecular Formula:
- C15H12O5
- Molecular Weight:
- 272.25
- MDL Number:
- MFCD00016762
- MOL File:
- 73692-50-9.mol
| Melting point | 173-174℃ |
|---|---|
| Boiling point | 538.7±50.0 °C(Predicted) |
| Density | 1.483±0.06 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility |
DMF:15.0(Max Conc. mg/mL);55.0(Max Conc. mM) DMSO:10.0(Max Conc. mg/mL);36.0(Max Conc. mM) Ethanol:1.0(Max Conc. mg/mL);3.6(Max Conc. mM) |
| form | A solid |
| pka | 6.82±0.40(Predicted) |
| color | Light yellow to orange |
| LogP | 2.826 (est) |
| FDA UNII | YCF6Z24AS2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H335-H319-H315 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
NARINGENIN CHALCONE price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 361831 | Naringenin Chalcone | 73692-50-9 | 20mg | $523 | 2021-12-16 | Buy |
| Arctom | CFN90606 | Naringeninchalcone ≥98% | 73692-50-9 | 20mg | $168 | 2021-12-16 | Buy |
| Arctom | SY232491 | Naringeninchalcone ≥97% | 73692-50-9 | 10mg | $171.82 | 2021-12-16 | Buy |
| AvaChem | 3383 | Naringenin chalcone | 73692-50-9 | 20mg | $275 | 2021-12-16 | Buy |
NARINGENIN CHALCONE Chemical Properties,Uses,Production
Uses
Naringenin chalcone is an orally active intermediate in flavonol biosynthesis. Naringenin chalcone induces Apoptosis. Naringenin chalcone inhibits the production of MCP-1 and NO. Naringenin chalcone exhibits anticancer activity against glioblastoma. Naringenin chalcone has anti-inflammatory and anti-allergic properties[1][2][3][4][5][6].
Definition
ChEBI: A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 2' ,4, 4', and 6' respectively.
in vivo
Naringenin chalcone (0.8 mg/kg; p.o.; daily) reduces eosinophilic airway inflammation, airway hyperresponsiveness, suppressed Th2 cytokine production by splenic CD4+ T cells, and slightly reduced mucus overproduction in allergic asthmatic BALB/c mice[2].
Naringenin chalcone (5-80 mg/kg; 24 days) reduced tumor volume and tumor weight in U87MG human glioblastoma xenograft Balb/c nude mice[3].
Naringenin chalcone (p.o.) increases plasma adiponectin levels in diabetic mice[4].
Naringenin chalcone (0.02%; i.v.) inhibits the anaphylactic response to IgE-mediated passive cutaneous anaphylaxis in CD-1 mice[5].
Naringenin chalcone (20 mg/kg; p.o.; once) resultes in the detection of naringenin chalcone -2'-O-β-D-glucuronide in the plasma of male Sprague-Dawley rats[6].
References
[1] Hirai S, et al. Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages. Life Sci. 2007 Sep 29;81(16):1272-9. DOI:10.1016/j.lfs.2007.09.001
[2] Iwamura C, et al. Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells. Allergol Int. 2010 Mar;59(1):67-73. DOI:10.2332/allergolint.09-OA-0118
[3] Zhang S, et al. Anti-cancer effect of naringenin chalcone is mediated via the induction of autophagy, apoptosis and activation of PI3K/Akt signalling pathway. Bangladesh Journal of Pharmacology, 2016, 11(3): 684-690.
[4] Horiba T, et al. Naringenin chalcone improves adipocyte functions by enhancing adiponectin production. Mol Cell Endocrinol. 2010 Jul 29;323(2):208-14. DOI:10.1016/j.mce.2010.03.020
[5] Escribano-Ferrer E, et al. In Vivo Anti-inflammatory and Antiallergic Activity of Pure Naringenin, Naringenin Chalcone, and Quercetin in Mice. J Nat Prod. 2019 Feb 22;82(2):177-182. DOI:10.1021/acs.jnatprod.8b00366
[6] Yoshimura M, et al. Identification and quantification of metabolites of orally administered naringenin chalcone in rats. J Agric Food Chem. 2009 Jul 22;57(14):6432-7. DOI:10.1021/jf901137x
NARINGENIN CHALCONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10244 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3461 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
View Lastest Price from NARINGENIN CHALCONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | (E)-Naringenin chalcone
73692-50-9
|
US $39.00-128.00 / mg | 99.77% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-03-10 | NARINGENIN CHALCONE
73692-50-9
|
US $6.00 / KG | 1KG | 98% | 1kg, 10kg ,50kg | Career Henan Chemical Co |
-
- (E)-Naringenin chalcone
73692-50-9
- US $39.00-128.00 / mg
- 99.77%
- TargetMol Chemicals Inc.
-
- NARINGENIN CHALCONE
73692-50-9
- US $6.00 / KG
- 98%
- Career Henan Chemical Co