N2,9-Diacetylguanine
- CAS No.
- 3056-33-5
- Chemical Name:
- N2,9-Diacetylguanine
- Synonyms
- DIACETYL GUANINE;2,9-DIACETYLGUANINE;N2,9-DIACETYLGUANINE;2,9-DAG;9-diacetylguanine;N,9-DIACETYLGUANINE;2,9-DIACETATEGUANINE;2,9-Guanine Diacetate;N2,N9-Diacetylguanine;Acyclovir EP Impurity L
- CBNumber:
- CB6183086
- Molecular Formula:
- C9H9N5O3
- Molecular Weight:
- 235.2
- MDL Number:
- MFCD00142116
- MOL File:
- 3056-33-5.mol
| Melting point | 285 °C(lit.) |
|---|---|
| Density | 1.67±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated) |
| form | Solid |
| pka | 8.37±0.20(Predicted) |
| color | White to Light Beige |
| InChI | InChI=1S/C9H9N5O3/c1-4(15)11-9-12-7-6(8(17)13-9)10-3-14(7)5(2)16/h3H,1-2H3,(H2,11,12,13,15,17) |
| InChIKey | GILZZWCROUGLIS-UHFFFAOYSA-N |
| SMILES | C(NC1NC(=O)C2=C(N=1)N(C(C)=O)C=N2)(=O)C |
| CAS DataBase Reference | 3056-33-5(CAS DataBase Reference) |
| FDA UNII | VUW2B9YR95 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
N2,9-Diacetylguanine price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D3604 | N2,9-Diacetylguanine >95.0%(T) | 3056-33-5 | 25g | $92 | 2024-03-01 | Buy |
| Alfa Aesar | B22709 | N(2),9-Diacetylguanine, 99% | 3056-33-5 | 5g | $51.65 | 2024-03-01 | Buy |
| TRC | D335000 | N2,9-Diacetylguanine | 3056-33-5 | 50g | $200 | 2021-12-16 | Buy |
| Usbiological | D3441-50 | N 2,9-Diacetylguanine | 3056-33-5 | 10g | $319 | 2021-12-16 | Buy |
| TRC | D335000 | N2,9-Diacetylguanine | 3056-33-5 | 100g | $400 | 2021-12-16 | Buy |
N2,9-Diacetylguanine Chemical Properties,Uses,Production
Description
N2,9-Diacetylguanine is a purine compound that can be prepared by acetylation of guanine with acetic anhydride. It can be used in many fields such as organic synthesis, biological research and pharmaceutical manufacturing. N2,9-Diacetylguanine can be prepared into 2-amino-6-halogenated purine under the action of two-step PEG-2000 phase transfer catalyst and TPPB phase transfer catalyst, and further through the corresponding CuX-catalyzed diazotization reaction, new 2-halogenated purine compounds can be efficiently synthesized[2]. In addition, it can also be used as an intermediate for the antiviral drugs Ganciclovir and Aciclovir.
Chemical Properties
white or brownish crystalline powder
Uses
N2,9-Diacetylguanine (Acicclovir EP Impurity L) is used to synthesize acyclic analogues of deoxyguanosine.
Application
The alkylation of N2,N9- diacetylguanine (DAG) with 2-oxa-1, 4-butane-dioldiacetate to give N2-acetyl-9-{2-acetoxyethoxymethyl}- guanine (N9 isomer) and/or N2-acetyl-7-{2-acetoxyethoxymethyl}- guanine (N7 isomer) in exceptionally high regioselectivity[1].
References
[1] Dharmendra Singh, Ashok Kumar, Mukesh J. Wani. “A Simple Solution to the Age Old Problem of Regioselective Functionalization of Guanine: First Practical Synthesis of Acyclic N9- and/or N7-Guanine Nucleosides Starting from N2,N9-Diacetylguanine.” The Journal of Organic Chemistry 64 13 (1999): 4665–4668.
[2] Y. HU. Synthesis of Some Biologically Active Halogenopurines[J]. Journal of the Korean Chemical Society-Daehan Hwahak Hoe Jee, 2010. DOI:10.5012/JKCS.2010.54.4.429.
N2,9-Diacetylguanine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12839 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
| Henan Xiangtong Chemical Co., Ltd. | 86-371-61312303 | info@hnxtchem.com | CHINA | 292 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
View Lastest Price from N2,9-Diacetylguanine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-28 | N,9-Diacetylguanine
3056-33-5
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Weibang Biotechnology Co., Ltd | |
 |
2024-11-28 | N(2),9-Diacetylguanine
3056-33-5
|
US $0.00 / Kg | 1Kg | 98% | 20Ton | Xinxiang Aurora Biotechnology Co.,Ltd. | |
 |
2024-11-27 | N,9-Diacetylguanine
3056-33-5
|
US $0.00 / KG | 1KG | 98% | 500kgs/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- N,9-Diacetylguanine
3056-33-5
- US $10.00 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
-
- N(2),9-Diacetylguanine
3056-33-5
- US $0.00 / Kg
- 98%
- Xinxiang Aurora Biotechnology Co.,Ltd.
-
- N,9-Diacetylguanine
3056-33-5
- US $0.00 / KG
- 98%
- WUHAN FORTUNA CHEMICAL CO., LTD
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