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(S)-1-Boc-3-hydroxypiperidine

(S)-1-Boc-3-hydroxypiperidine Structure
(S)-1-Boc-3-hydroxypiperidine structure
CAS No.
143900-44-1
Chemical Name:
(S)-1-Boc-3-hydroxypiperidine
Synonyms
tert-butyl (S)-3-hydroxypiperidine-1-carboxylate;(S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;Ibrutinib Interm 0441;CAS:143900-44-1;1,1-DiMethylethy;(S)-BOC-piperidinol;Ilutinib impurity 7;(S)-1-BOC-3-PIPERIDINOL;（S）-N-BOC-3-piperidinol;(S)-1-BOC-Piperidin-3-ol
CBNumber:
CB6197360
Molecular Formula:
C10H19NO3
Molecular Weight:
201.26
MDL Number:
MFCD06659041
MOL File:
143900-44-1.mol
MSDS File:
SDS
Last updated:2025-04-17 18:45:41
Request For Quotation

(S)-1-Boc-3-hydroxypiperidine Properties

Melting point 34-40 °C
Boiling point 292.3±33.0 °C(Predicted)
Density 1.107±0.06 g/cm3(Predicted)
Flash point 110 °C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in methanol.
pka 14.74±0.20(Predicted)
form Powder or Crystalline Powder
color White to tan
optical activity [α]22/D +10.0°, c = 1 in chloroform
InChI InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m0/s1
InChIKey UIJXHKXIOCDSEB-QMMMGPOBSA-N
SMILES N1(C(OC(C)(C)C)=O)CCC[C@H](O)C1
CAS DataBase Reference 143900-44-1(CAS DataBase Reference)
UNSPSC Code 12352005
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37/39
WGK Germany  3
HS Code  29339900
NFPA 704
1
2 0

(S)-1-Boc-3-hydroxypiperidine price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 687367 (S)-1-Boc-3-hydroxypiperidine 97% 143900-44-1 1g $112 2024-03-01 Buy
TCI Chemical B4446 (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC) 143900-44-1 1g $21 2024-03-01 Buy
TCI Chemical B4446 (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC) 143900-44-1 5g $64 2024-03-01 Buy
Alfa Aesar H52771 (S)-1-Boc-3-hydroxypiperidine, 97% 143900-44-1 1g $50.65 2024-03-01 Buy
Alfa Aesar H52771 (S)-1-Boc-3-hydroxypiperidine, 97% 143900-44-1 5g $207.65 2024-03-01 Buy
Product number Packaging Price Buy
687367 1g $112 Buy
B4446 1g $21 Buy
B4446 5g $64 Buy
H52771 1g $50.65 Buy
H52771 5g $207.65 Buy

(S)-1-Boc-3-hydroxypiperidine Chemical Properties,Uses,Production

Uses

(S)-1-Boc-3-hydroxypiperidine is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies. Synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma.

Description

(S)-1-Boc-3-hydroxypiperidine, alias (S)-N-Boc-3-hydroxypiperidine (S-NBHP) is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies.S-NBHP can be prepared in a variety of ways such as chemically or biocatalytically. S-NBHP can be prepared in various ways, such as chemical synthesis or biocatalysis. Biocatalysis is an efficient process for the reduction of N-Boc-piperidin-3-one by recombinant keto reductase (KRED) catalytic to obtain optically pure S-NBHP using 99% yield. The asymmetric reduction of N-Boc-piperidin-3-one (NBPO) to (S)-NBHP can also be catalysed by a reductase (YDR541C) isolated from Saccharomyces cerevisiae in 99% yield.

Chemical Properties

White powder

Uses

A piperidine derivative with an amine protecting group, (S)-1-Boc-3-hydroxypiperidine can be used in the preparation of biologically active compounds such as antagonists of the human P2X7 receptor and selective irreversible inhibitors for bruton's tyrosine kinase.

Uses

(S)-1-Boc-3-hydroxypiperidine is used as pharmaceutical intermediate.

(S)-1-Boc-3-hydroxypiperidine synthesis

98977-36-7
143900-44-1
Synthesis of (S)-1-Boc-3-hydroxypiperidine from 1-Boc-3-piperidone

(S)-1-Boc-3-hydroxypiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-3-Hydroxypiperidine hydrochloride (3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine (S)-3-Methoxypiperidine (S)-3-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester (S)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE

(S)-1-Boc-3-hydroxypiperidine Suppliers

Global( 617)Suppliers
Supplier Tel Email Country ProdList Advantage
SyncoZymes (Shanghai) Co., Ltd.,
+8613681683526 lchen@syncozymes.com China 188 58
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.
+86-18616643091 +86-18616643091 info@rochipharma.com China 246 58
Lianhe Aigen Pharmatech Co.,Ltd.
+undefined+undefined18918657159 sales@lianhe-aigen.com China 316 58
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410 sales@ichemie.com China 1015 58
Hebei Ganmiao New material Technology Co., LTD 		+86-17332992504 +86-17332992504 sales8@hbganmiao.com China 300 58
Shaanxi Xianhe Biotech Co., Ltd 		+8617709210191 Jerry@xhobio.com China 884 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 +86-16264648883 niki@zlchemi.com China 7245 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29730 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21628 55
Supplier Advantage
SyncoZymes (Shanghai) Co., Ltd.,
58
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.
58
Lianhe Aigen Pharmatech Co.,Ltd.
58
Hangzhou ICH Biofarm Co., Ltd 		58
Hebei Ganmiao New material Technology Co., LTD 		58
Shaanxi Xianhe Biotech Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co Ltd 		58
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55

Related articles

View Lastest Price from (S)-1-Boc-3-hydroxypiperidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-1-Boc-3-hydroxypiperidine pictures 2025-04-25 (S)-1-Boc-3-hydroxypiperidine
143900-44-1
 US $50.00 / kg 1kg 99 5000 Hebei Zhuanglai Chemical Trading Co Ltd
(S)-N-tert-Butoxycarbonyl-3-hydroxypiperidine pictures 2025-04-24 (S)-N-tert-Butoxycarbonyl-3-hydroxypiperidine
143900-44-1
 US $0.00 / kg 1kg 0.99 1000kg Shaanxi Xianhe Biotech Co., Ltd
(S)-1-Boc-3-hydroxypiperidine pictures 2025-04-04 (S)-1-Boc-3-hydroxypiperidine
143900-44-1
 US $0.00-0.00 / KG 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.

(S)-1-Boc-3-hydroxypiperidine Spectrum

(S)-1-Boc-3-hydroxypiperidine(143900-44-1)1HNMR

143900-44-1((S)-1-Boc-3-hydroxypiperidine)Related Search:

3-Hydroxypiperidine tert-Butyl acetate tert-Butyl peroxyacetate Haloperidol tert-Butanol
(R)-1-BOC-3-HYDROXYPIPERIDINE,(R)-1-N-BOC-3-HYDROXYPIPERIDINE,(R)-N-BOC-3-HYDROXYPIPERIDINE Btk inhibitor 1 (R enantioMer hydrochloride) Ibrutinib Impurity 21 N-BOC-2-HYDROXYPIPERIDINE (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one
Ibrutinib Impurity 24 Ibrutinib (S)-Ibrutinib (S)-3-Hydroxypiperidine Ibrutinib Dimer Impurity
Ibrutinib Impurity 28 Ibrutinib Impurity 25 Acrylic anhydride

1of4

(S)-3-HYDROXY-1-(TERT-BUTOXYCARBONYL)PIPERIDINE (S)-1-BOC-3-HYDROXYPIPERIDINE (S)-1-BOC-3-PIPERIDINOL (S)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPIPERIDINE HYDROCHLORIDE (S)-N-BOC-3-HYDROXY PIPERIDINE (S)-TERT BUTYL-3-HYDROXYPIPERIDINE-1-CARBOXYLATE 1-PIPERIDINECARBOXYLIC ACID, 3-HYDROXY-, 1,1-DIMETHYLETHYL ESTER, (3S)- (S)-1-Boc-3-hydroxypiperidine 97% 15. (S)-tert-butyl 3-hydroxypiperidine-1-carboxylate1 (S)-1-TERT-BUTOXYCARBONYL-3-HYDROXYPIPERIDINE (S)-1-BOC-3-HYDROXYPIPERIDINE 3PC-20160102 [REJECTED MATERIAL IS SENDING BACK TOYOU DUE TO FAILED IN QUALITY PARAMETERS (S)-N-Boc-3-hydroxypiperidine,98%e.e. (S)-1-Boc-3-hydroxypiperi... tert-Butyl (3S)-3-hydroxypiperidine-1-carboxylate, (3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine (S)-tert-butyl 3-hydroxypiperidin-1-carboxylate (3S)-3-Hydroxy-1-piperidinecarboxylic Acid 1,1-diMethylethyl Ester 1,1-DiMethylethy tert- butyl (3S)-3-hydroxy piperidine-1-carboxylate (3S)-hydroxy-1-piperidinecarboxylic acid 1,1-diMethylethyl ester (S)-1-Boc-3-hydroxypiperidine,97% (S)-1-Boc-3-hydroxypiperidine (S)-N-tert-Butoxycarbonyl-3-hydroxypiperidine (S)-1-N-BOC-3-HYDROXY-PIPERIDINE (S)-N-tert-Butoxycarbonyl-3-hydroxypiperidine (S)-3-Hydroxypiperidine, N-BOC protected (S)-1-BOC-Piperidin-3-ol (S)-1-Boc-3-hydroxypiperidine,(S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate (3S)-3-Hydroxypiperidine, N-BOC protected tert-butyl (S)-3-hydroxypiperidine-1-carboxylate143900-44-1 (S)-1-Boc-3-Hdroxypiperidine (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine > (S)-1-tert-butyrolactone-3-hydroxypiperidine （S）-N-BOC-3-piperidinol (S)-1-Boc-4-hydroxypiperidine (S) -1-tert-butyloxycarbonyl-3-hydroxypiperidine (S)-1-BOC-3-HYDROXYPIPERIDINE, IBRUTINIB INT (S)-1-Boc-3-hydroxypiperidine ISO 9001：2015 REACH (S)-BOC-piperidinol (S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER tert-butyl (S)-3-hydroxypiperidine-1-carboxylate Ibrutinib Interm 0441 Thieno[2,3-c]pyridine-3-carboxylicacid,2-amino-4,5,6,7-tetrahydro-8-(phenylmethyl)-,ethylester Carbamicacid,N-[2-(2-hydroxyethoxy)ethyl]-,1,6-dimethylethylester 1-Piperidinecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester, (3S)- (9CI, ACI) 3-hydroxy-1-Piperidinecarboxylic acid 1,1-dimethylethyl ester (3S)- (9CI ACI) 3-Hydroxy-1-piperidinecarboxylic acid tert-butyl ester (3S)- (S) 1-tert-butoxycarbonyl-3-hydroxypyridine Ilutinib impurity 7 CAS:143900-44-1 (S)-1-Boc-3-hydroxypiperidine (S)-1-(tert-Butoxycarbonyl)-3-carboxypiperidine 143900-44-1 14390-44-1 14390-44-1 43900-44-1 C10H19NO3HCl New Products for Chemical Synthesis May/June 2007 Piperazine Chiral Reagents