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PROCYCLIDINE HYDROCHLORIDE

CAS No.
1508-76-5
Chemical Name:
PROCYCLIDINE HYDROCHLORIDE
Synonyms
kemadrin;PROCYCLIDINE HCL;D00782;Osnervan;Arpicolin;Kemadrin (tn);kemadrinhydrochloride;PROCYCLIDINE HYDROCHLORIDE;(±)-Procyclidine hydrochlorid;Procyclidine hydrochloride (usp)
CBNumber:
CB6229812
Molecular Formula:
C19H30ClNO
Molecular Weight:
323.9
MDL Number:
MFCD00079236
MOL File:
1508-76-5.mol
MSDS File:
SDS
Last updated:2023-06-08 09:03:02

PROCYCLIDINE HYDROCHLORIDE Properties

Melting point 159-164 °C
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
form Solid
color White to Off-White
FDA UNII CQC932Z7YW

Pharmacokinetic data

Excreted unchanged in urine <5%
Volume of distribution 1(L/kg)
Biological half-life 12 / -

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264b-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364-P403-P501c
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36
WGK Germany  3
RTECS  UY1926000
HS Code  2933997500
Toxicity mouse,LD50,intravenous,14mg/kg (14mg/kg),BEHAVIORAL: TREMORLUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 383, 1955.
NFPA 704
0
2 0

PROCYCLIDINE HYDROCHLORIDE price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P3794 Procyclidine hydrochloride 1508-76-5 1g $159 2024-03-01 Buy
Sigma-Aldrich 1567004 Procyclidine hydrochloride United States Pharmacopeia (USP) Reference Standard 1508-76-5 200mg $174.4 2024-03-01 Buy
Sigma-Aldrich P3794 Procyclidine hydrochloride 1508-76-5 5g $629 2024-03-01 Buy
Usbiological 019991 Procyclidine Hydrochloride 1508-76-5 10mg $460 2021-12-16 Buy
TRC P755840 Procyclidine hydrochloride 1508-76-5 5g $480 2021-12-16 Buy
Product number Packaging Price Buy
P3794 1g $159 Buy
1567004 200mg $174.4 Buy
P3794 5g $629 Buy
019991 10mg $460 Buy
P755840 5g $480 Buy

PROCYCLIDINE HYDROCHLORIDE Chemical Properties,Uses,Production

Uses

An anticholinergic drug used in the treatment parkinson’s disease. It is also used to treat patients suffering from drug-induced parkinsonism, akathisia and acute dystonia.

brand name

Kemadrin (Monarch).

General Description

Procyclidine hydrochloride,α-cyclohexyl-α-phenyl-1-pyrrolidinepropanolhydrochloride (Kemadrin), was introduced in 1956. Althoughit is an effective peripheral anticholinergic and, indeed, hasbeen used for peripheral effects similar to its methochloride(i.e., tricyclamol chloride), its clinical usefulness lies inits ability to relieve voluntary muscle spasticity by its centralaction. Therefore, it has been used with success in thetreatment of Parkinson syndrome. It is said to be as effectiveas trihexyphenidyl and is used to reduce muscle rigidityin postencephalitic, arteriosclerotic, and idiopathic types ofthe disease. Its effect on tremor is not predictable and probablyshould be supplemented by combination with othersimilar drugs.
The toxicity of the drug is low, but when the dosageof the drug is high, side effects are noticeable. At therapeuticdosage levels, dry mouth is the most common sideeffect. The same care should be exercised with this drugas with all other anticholinergics when it is administeredto patients with glaucoma, tachycardia, or prostatichypertrophy.

Biochem/physiol Actions

Procyclidine is a synthetic anti-cholinergic agent and atropine-like antispasmodic. It exhibits therapeutic effects against Parkinson′s disease and schizophrenia. Procyclidine acts as a muscarinic receptor antagonist. It also affects N-methyl-D-aspartate (NMDA) glutamine and nicotinic acetylcholine receptors to a lower extent.

Clinical Use


Control of extrapyramidal symptoms
Acute dystonias

Metabolism

When given orally about one fifth of the dose is known to be metabolised in the liver, principally by cytochrome P450 and then conjugated with glucuronic acid. Metabolites have been found in the urine.

PROCYCLIDINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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alpha-cyclohexyl-alpha-phenyl-1-pyrrolidinepropanomonohydrochloride kemadrinhydrochloride PROCYCLIDINE HYDROCHLORIDE ALPHA-CYCLOHEXYL-ALPHA-PHENYL-1-PYRROLIDINEPROPANOL HYDROCHLORIDE α-Cyclohexyl-α-phenyl-1-pyrrolidinepropanol D00782 Kemadrin (tn) Procyclidine hydrochloride (usp) Procyclidine Hydrochloride (200 mg) Arpicolin Osnervan α-Cyclohexyl-α-phenyl-1-pyrrolidinepropanol Hydrochloride α-Cyclohexyl-α-phenyl-1-pyrrolidinopropanol 1-Pyrrolidinepropanol, .alpha.-cyclohexyl-.alpha.-phenyl-, hydrochloride Procyclidine Hydrochloride (1567004) a-Cyclohexyl-a-phenyl-1-pyrrolidinepropanol hydrochloride (±)-Procyclidine hydrochlorid Procyclidine HydrochlorideQ: What is Procyclidine Hydrochloride Q: What is the CAS Number of Procyclidine Hydrochloride Q: What is the storage condition of Procyclidine Hydrochloride Q: What are the applications of Procyclidine Hydrochloride Procyclidine-d11 HydrochlorideQ: What is Procyclidine-d11 Hydrochloride Q: What is the CAS Number of Procyclidine-d11 Hydrochloride kemadrin PROCYCLIDINE HCL Soman,Tricyclamol,inhibit,mAChR,Procyclidine,Parkinson's disease,Ionotropic glutamate receptors,anticholinergic,Inhibitor,(±)-Procyclidine,Muscarinic acetylcholine receptor,NMDA,Procyclidine hydrochloride,muscarinic receptor,epilepsy,iGluR -(1,2-Propanediyl)bis[1-(4-morpholinylmethyl)-2,6-piperazinedione Procyclidine hydrochloride in methanol 1508-76-5 C19H29NOHCl KEMADRIN Aromatics Heterocycles Intermediates & Fine Chemicals Neurochemicals Pharmaceuticals