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1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE

1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE Structure
1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE structure
CAS No.
104113-71-5
Chemical Name:
1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
Synonyms
NPPI;TIMTEC-BB SBB003161;1-(1-NAPHTHYL)PIPERAZINE;1-(1-NAPHTHYL)PIPERAZINE HCL;1-(1-Naphthalenyl)piperazine;1-(Piperazin-1-yl)naphthalene;1-(1-Naphthyl)piperazine*2HCl;1-(Naphth-1-yl)piperazine diHCl;1-(Naphthalen-1-yl)piperazineHCl;1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
CBNumber:
CB6244792
Molecular Formula:
C14H17ClN2
Molecular Weight:
248.75
MDL Number:
MFCD00055161
MOL File:
104113-71-5.mol
MSDS File:
SDS
Last updated:2024-11-19 20:33:22
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1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE Properties

Melting point 235-237 °C
storage temp. Store at -20°C
solubility H2O: soluble
form needles
color white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
WGK Germany  3
NFPA 704
0
2 0

1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar J62097 1-(1-Naphthyl)piperazine hydrochloride 104113-71-5 1g $276 2024-03-01 Buy
Alfa Aesar J62097 1-(1-Naphthyl)piperazine hydrochloride 104113-71-5 5g $661 2023-06-20 Buy
Cayman Chemical 16150 1-(1-Naphthyl) piperazine (hydrochloride) ≥98% 104113-71-5 25mg $73 2024-03-01 Buy
Cayman Chemical 16150 1-(1-Naphthyl) piperazine (hydrochloride) ≥98% 104113-71-5 50mg $116 2024-03-01 Buy
Cayman Chemical 16150 1-(1-Naphthyl) piperazine (hydrochloride) ≥98% 104113-71-5 100mg $217 2024-03-01 Buy
Product number Packaging Price Buy
J62097 1g $276 Buy
J62097 5g $661 Buy
16150 25mg $73 Buy
16150 50mg $116 Buy
16150 100mg $217 Buy

1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE Chemical Properties,Uses,Production

Description

1-(1-Naphthyl)piperazine (1-NP) is a ligand for serotonin (5-hydroxytryptamine, 5-HT) receptors. It acts as an antagonist for 5-HT at 5-HT1 and 5-HT2 in rat cortical membranes with IC50 values of 6 and 1 nM, respectively. 1-NP also blocks contraction in the rat fundus induced by either 5-HT or tryptamine (IC50 = 1 nM for both agonists). 1-NP mimics the 5-HT1 agonist 1-(m-trifluoromethylphenyl)piperazine (TFMPP, ) in decreasing 5-HT receptor turnover and increasing serum corticosterone, suggesting that, in the absence of 5-HT, 1-NP may act as an agonist of the 5-HT1 receptor. However, in squirrel monkeys, 1-NP acts as a non-selective 5-HT receptor antagonist in altering operant behavior. 1-NP also binds to the human 5-HT6 receptor with an affinity comparable to that of 5-HT (Kis = 120 and 100 nM, respectively).

Uses

1-(1-Naphthyl)piperazinemiddotHCl is a mixed agonist/antagonist of the serotonin receptors.

in vitro

1-np binds to human 5- ht6 (h5-ht6) serotonin receptors with a ki of 120 nm [1]. in rat cortical membranes, 1-np inhibited the activity of 5-ht1 and 5-ht2 with ic50 values of 6 and 1 nm, respectively. 1-np also blocked contraction in the rat fundus induced by either 5-ht or tryptamine with an ic50 of 1 nm [3].

in vivo

in squirrel monkeys, 1-np (0.3–1.0 mg/kg) blocked the decrease of responding under fixed-interval (fi) schedules of presentation of food caused by dob (0.01–0.3 mg/kg), an agonist of 5-ht2. 1-np also antagonized the decreases in responding produced by quipazine (0.1–5.6 mg/kg), another agonist with predominant 5-ht2 actions [4].

References

[1] lee m, rangisetty j b, pullagurla m r, et al. 1-(1-naphthyl) piperazine as a novel template for 5-ht 6 serotonin receptor ligands[j]. bioorganic & medicinal chemistry letters, 2005, 15(6): 1707-1711.
[2] nichols d e, nichols c d. serotonin receptors[j]. chemical reviews, 2008, 108(5): 1614-1641.
[3] cohen m l, wittenauer l a. relationship between serotonin and tryptamine receptors in the rat stomach fundus[j]. journal of pharmacology and experimental therapeutics, 1985, 233(1): 75-79.
[4] mckearney j w. serotonin-antagonist effects of 1-(1-naphthyl) piperazine on operant behavior of squirrel monkeys[j]. neuropharmacology, 1989, 28(8): 817-821.

1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE Suppliers

Global( 41)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29810 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Nanjing Bicbiotechnology Co., Ltd 		+86-2552131256 +86-18251840740 sales@bicbiotech.com China 5994 58
Shanghai Latchem Co., Ltd. 021-61916491 15921747686 sales@latcheminc.com China 979 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35896 56
Nanjing Vital Chemical Co., Ltd. Please Send Email 18652950785 chemweiao@163.com China 4378 65
Supplier Advantage
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
LEAPCHEM CO., LTD. 		58
Nanjing Bicbiotechnology Co., Ltd 		58
Shanghai Latchem Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Wuhan Chemwish Technology Co., Ltd 56
Nanjing Vital Chemical Co., Ltd. 65

View Lastest Price from 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-(1-Naphthyl) piperazine hydrochloride pictures 2024-11-19 1-(1-Naphthyl) piperazine hydrochloride
104113-71-5
 US $29.00-77.00 / mg 98.27% 10g TargetMol Chemicals Inc.
1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE pictures 2020-02-19 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
104113-71-5
 US $1.00 / KG 1KG 99% 200kgs Career Henan Chemical Co

104113-71-5(1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE)Related Search:

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1-(1-NAPHTHYL)PIPERAZINE 1-(1-NAPHTHYL)PIPERAZINE HCL 1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE 1-(1-Naphthalenyl)piperazine 1-(Piperazin-1-yl)naphthalene 1-(Naphthalen-1-yl)piperazineHCl 1-(1-Naphthyl)piperazine*2HCl Piperazine, 1-(1-naphthalenyl)-, hydrochloride (1:1) TIMTEC-BB SBB003161 NPPI 1-NAPHTHALEN-1-YL-PIPERAZINE HYDROCHLORIDE 1-(Naphth-1-yl)piperazine diHCl Piperazine, 1-(1-naphthalenyl)-, monohydrochloride 1 (1 Naphthyl) piperazine hydrochloride,1(1Naphthyl) piperazine hydrochloride 104113-71-5