ANTI-PRESENILIN 1 (PS1, S182)
- CAS No.
- Chemical Name:
- ANTI-PRESENILIN 1 (PS1, S182)
- Synonyms
- ANTI-PRESENILIN 1 (PS1, S182);Anti-Presenilin-1 (S182) antibody produced in rabbit
- CBNumber:
- CB6247399
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD02097229
- MOL File:
- Mol file
ANTI-PRESENILIN 1 (PS1, S182) Chemical Properties,Uses,Production
Uses
Anti-Presenilin-1 (S182) antibody produced in rabbit has been used in:
- immunostaining
- immunofluorescence detection
- immunohistochemistry
- immunoblotting
General Description
Presenilin 1& 2 (PS1 and PS2) are highly homologous proteins (approx. 43-52 kD) with eight transmembrane domains. In the brain, PS1 and PS2 are expressed primarily in neurons and localized mainly in cell bodies, axons and dendrites. In non-neuronal cells, PS1 and PS2 are localized to the nuclear membrane, endoplasmic reticulum and Golgi. Presenilin 1 is located on chromosome 14.
Biochem/physiol Actions
The biological functions of the presenilin′s are yet unknown, but they are thought to be involved in protein trafficking. Mutations in the presenilin 1 (PS1) gene (>30 known pathogenic mutations) have been found in about half of the early-onset familial Alzheimer′s disease (FAD), while only two pathogenic mutations have been found in PS2.
ANTI-PRESENILIN 1 (PS1, S182) Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-PRESENILIN 1 (PS1, S182) Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Riedel-de Haen AG | -- | United States | 6825 | 87 | |
SIGMA-RBI | -- | Switzerland | 6913 | 91 |
Supplier | Advantage |
---|---|
Riedel-de Haen AG | 87 |
SIGMA-RBI | 91 |