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Lomitapide

Lomitapide structure

CAS No.: 182431-12-5

Chemical Name:: Lomitapide

Synonyms: AEGR 733;BMS 201038;LoMitapide;BMS 201238;BMS 201038-01;AEGR733, BMS201038;AEGR-733(Lomitapide);CB62485047,loMitapide;Lomitapide (10mM in DMSO);AEGR-733(Lomitapide)free base

CBNumber:: CB62485047

Molecular Formula:: C39H37F6N3O2

Molecular Weight:: 693.72

MDL Number:: MFCD16620494

MOL File:: 182431-12-5.mol

MSDS File:: SDS

Last updated:2024-11-19 23:02:33

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Lomitapide Properties

Melting point	142°C(lit.)
Boiling point	778.2±60.0 °C(Predicted)
Density	1.34±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	12.66±0.20(Predicted)
form	powder
color	white to beige
FDA UNII	82KUB0583F
ATC code	C10AX12

SAFETY

Risk and Safety Statements

HS Code	2933.39.4100

Lomitapide price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1385	Lomitapide ≥98% (HPLC)	182431-12-5	5MG	$173	2024-03-01	Buy
Sigma-Aldrich	SML1385	Lomitapide ≥98% (HPLC)	182431-12-5	25MG	$693	2024-03-01	Buy
TCI Chemical	L0298	Lomitapide >98.0%(HPLC)	182431-12-5	25mg	$112	2024-03-01	Buy
TCI Chemical	L0298	Lomitapide >98.0%(HPLC)	182431-12-5	100mg	$302	2024-03-01	Buy
Cayman Chemical	10009610	Lomitapide ≥98%	182431-12-5	1mg	$32	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML1385	5MG	$173	Buy
SML1385	25MG	$693	Buy
L0298	25mg	$112	Buy
L0298	100mg	$302	Buy
10009610	1mg	$32	Buy

Lomitapide Chemical Properties,Uses,Production

Description

Lomitapide was approved by the US FDA in December 2012 for the treatment of patients with familial hypercholesteremia (referred to as HoFH) in conjunction with a low-fat diet andother lipid-lowering treatments. Lomitapide was discovered from a high-through put screen that identified several structurally distinct MTP inhibitors. Combination of key structural features from two structurally distinct HTS hits provided potent MTP inhibitors. Parallel analog synthesis led to lomitapide as an optimized structure. Lomitapide was synthesized via alkylation of 9-fluorenylcarboxylic acid with 1,4-dibromobutane which, after trifluoroethylamide formation, provided a bromide intermediate that was displaced by Boc-4-aminopiperidine. Introduction of the 4'-trifluoromethylbiphenylcarboxamide gave lomitapide, which was found to inhibit MTP with an IC₅₀ of 0.5 nM and to exhibit good cholesterol-lowering efficacy in Sprague–Dawley rats (intravenous and oral ED₅₀～0.2 mg/kg).

Originator

Bristol-Myers Squibb (United States)

Uses

Lomitapide has been used as a microsomal triglyceride transfer protein (MTP) inhibitor to study its effects on very-low-density lipoproteins (VLDL) export in mouse hepatocytes.

Definition

ChEBI: Lomitapide is a member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. It has a role as an anticholesteremic drug and a MTP inhibitor. It is a member of piperidines, a member of fluorenes, a member of benzamides and a member of (trifluoromethyl)benzenes. It is a conjugate base of a lomitapide(1+).

brand name

Juxtapid

Biochem/physiol Actions

Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP). Lomitapide has been shown to be highly effective in reducing LDL-cholesterol and triglycerides, and has been aproved for treatment of homozygous familial hypercholesterolemia.

Lomitapide Preparation Products And Raw materials

Raw materials

Preparation Products

Lomitapide Suppliers

Global( 134)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	+86-18600796368 +86-18600796368	sales@sjar-tech.com	China	444	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9639	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12373	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58

Supplier	Advantage
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	58
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Finetech Industry Limited	58
sgtlifesciences pvt ltd	58
InvivoChem	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from Lomitapide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Lomitapide 182431-12-5	US $59.00-148.00 / mg		99.77%	10g	TargetMol Chemicals Inc.
2024-11-18	Lomitapide 182431-12-5	US $0.00 / g	1g	More Than 99%	100kg/Month	BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
2024-10-22	AEGR-733 182431-12-5	US $1.00 / g	1g	MIn98% HPLC/LC	100KGS	Career Henan Chemica Co

Lomitapide
182431-12-5
US $59.00-148.00 / mg
99.77%
TargetMol Chemicals Inc.

Lomitapide
182431-12-5
US $0.00 / g
More Than 99%
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

AEGR-733
182431-12-5
US $1.00 / g
MIn98% HPLC/LC
Career Henan Chemica Co

Lomitapide Spectrum

N-(2,2,2-Trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]piperidin-1-yl]butyl)-9H-fluorene-9-carboxamide(182431-12-5)¹HNMR

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N-(2,2,2-Trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]piperidin-1-yl]butyl)-9H-fluorene-9-carboxamide N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide AEGR 733 BMS 201038 BMS 201038-01 BMS 201238 LoMitapide N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoroMethyl)biphenyl-2-ylcarboxaMido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxaMide CB62485047,loMitapide AEGR-733(Lomitapide)free base AEGR-733; BMS-201038; AEGR733; BMS201038; AEGR 733; BMS 201038; AEGR-733(Lomitapide) AEGR733, BMS201038 9H-Fluorene-9-carboxamide, N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]- N-(2,2,2-Trifluoroethyl)-9-[4-[4-[4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido]piperidin-1-yl]butyl]-9H-fluorene-9-carboxamide Lomitapide (10mM in DMSO) N-(2,2,2-Trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-... Lomitapide D8Q: What is Lomitapide D8 Q: What is the CAS Number of Lomitapide D8 Q: What is the storage condition of Lomitapide D8 N-(2,2,2-Trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]piperidin-1-yl]butyl)-9H-fluorene-9-carboxamide N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide 182431-12-5 C39H37F6N3O2 Inhibitors