ChemicalBook >> CAS DataBase List >>1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
- CAS No.
- 3543-73-5
- Chemical Name:
- 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
- Synonyms
- ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate;5-AMino-1-Methyl-;Bendamustine Intermediate;1-Methyl-5-amino-1H-benzimidazole-2;BendaMustine hydrochloride interMediate;endamustine Dideschloroethyl Ethyl Ester;BendaMustine Dideschloroethyl Ethyl Ester;Bendamustine hydrochloride Intermediates 2;4-(5-amino-1-methyl-1H-benzimidazol-2-yl)butanoate;Ethyl 5-amino-1-methyl-1H-benzimidazole-2-butanoate
- CBNumber:
- CB62485092
- Molecular Formula:
- C14H19N3O2
- Molecular Weight:
- 261.32
- MDL Number:
- MFCD09840909
- MOL File:
- 3543-73-5.mol
Last updated:2024-05-21 14:26:51
| Melting point | 130-135°C |
|---|---|
| Boiling point | 471.6±25.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| pka | 6.73±0.10(Predicted) |
| color | Off-White to Pale Beige |
| InChI | InChI=1S/C14H19N3O2/c1-3-19-14(18)6-4-5-13-16-11-9-10(15)7-8-12(11)17(13)2/h7-9H,3-6,15H2,1-2H3 |
| InChIKey | JUMGOLYNZBZPKE-UHFFFAOYSA-N |
| SMILES | C1(CCCC(OCC)=O)N(C)C2=CC=C(N)C=C2N=1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P305+P351+P338 |
| HS Code | 2933998090 |
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M285645 | 1-Methyl-5-amino-1H-benzimidazole-2-butanoicAcidEthylEster | 3543-73-5 | 5mg | $60 | 2021-12-16 | Buy |
| Matrix Scientific | 102756 | Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate >97% | 3543-73-5 | 1g | $92 | 2021-12-16 | Buy |
| AK Scientific | J97551 | 1-Methyl-5-amino-1H-benzimidazole-2-butanoicacidethylester | 3543-73-5 | 1g | $45 | 2021-12-16 | Buy |
| Matrix Scientific | 102756 | Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate >97% | 3543-73-5 | 5g | $342 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H58-1-CV | Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate | 3543-73-5 | 1g | $436 | 2021-12-16 | Buy |
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Chemical Properties,Uses,Production
Chemical Properties
Brown Solid
Uses
1-Methyl-5-amino-1H-benzimidazole-2-butanoic Acid Ethyl Ester is a Bendamustine impurity.
Synthesis
In the hydrogenation reaction kettle by adding 50 g 1 - methyl -5 - nitro - 1H - benzimidazole -2 - butyric acid ethyl ester, 2.5 g 5% palladium/carbon, 1.3 L methanol, 475 ml ethyl acetate, hydrogen pressure control in the 0.1 - 0.2 mpa, reaction solution is 25 °C reaction 15 hours, TLC monitoring endpoint of the reaction to the reaction is complete. The fluid in a 35 °C decompression filter collects the filtrate; the filtrate is concentrated under reduced pressure to dry after adding 75 ml ethyl acetate, 70 °C stirring for 0.5 hours. After that, the mixture was to 5 °C stirring for 0.5 hours, for 5 °C standing crystallization for 2 hours, filtering, washing the filter cake with acetic acid ethyl ester, filtration cake at 50 °C decompression drying for 5 hours to afford 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester 35 g, yield 77.8%.
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 205)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| JUYE XIANDAI fine chemistry Co.,Ltd | +86-18958038633; +8618958038633 | tony@sdhypharma.com | China | 64 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18774 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9206 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| Lianyungang happen teng technology co., LTD | 15950718863 | wang666xt@163.com | CHINA | 295 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
View Lastest Price from 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
3543-73-5
|
US $1.00 / kg | 1kg | 99% | Customized | Career Henan Chemical Co |
-
- 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
3543-73-5
- US $1.00 / kg
- 99%
- Career Henan Chemical Co
3543-73-5(1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester)Related Search:
5-AMINO-1-METHYL-1H-BENZIMIDAZOLE-2-BUTANOIC ACID ETHYL ESTER
Ethyl-4-(5-aMino-1-Methy-1H-benzo[d] iMidazol-2-yl)butanoate
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
4-(5-Amino-1-methyl-1H-benzoimidazol-2-yl)-butyric acidethylester
5-amino-1-methyl-2-Benzimidazolebutyric acid ethyl ester
5-AMino-1-Methyl-
4-[5-AMino-1-MethylbenziMidazol-2-yl]butanoic acid ethyl ester
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BendaMustine hydrochloride interMediate
4-(5-aMino-1-Methyl-1H-benzoiMidazol-2-yl)-butyric acid ethyl esterCAS
BendaMustine Dideschloroethyl Ethyl Ester
ethyl 4-(5-aMino-1-Methyl-1H-1,3-benzodiazol-2-yl)butanoate
ethyl 4-(5-amino-1-methylbenzimidazol-2-yl)butanoate
Bendamustine Intermediate
Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate
Bendamustine hydrochloride Intermediates 2
5-(5-amino-1-methyl-2-benzimidazolyl)-1-methoxy-2-pentanone
4-(5-amino-1-methyl-1H-benzimidazol-2-yl)butanoate
1-Methyl-5-amino-1H-benzimidazole-2
endamustine Dideschloroethyl Ethyl Ester
1H-Benzimidazole-2-butanoic acid, 5-amino-1-methyl-, ethyl ester
Ethyl4-(5-amino-1-methyl-1Hbenzo[d]imidazole
-2-yl)butanoate
ETHYL 4-(5-AMINO-1-METHYL-1HBENZIMIDAZOL-2-YL) BUTANOATE
ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate
Bendamustine Hydrochloride Intermediate 3543-73-5 API Manufacturer
Ethyl 5-amino-1-methyl-1H-benzimidazole-2-butanoate
3543-73-5
Aromatics
Heterocycles
Intermediates