EGFR/ErbB-2 Inhibitor
- CAS No.
- 179248-61-4
- Chemical Name:
- EGFR/ErbB-2 Inhibitor
- Synonyms
- ErbB2 inhibitor;EGFR/ErbB-2 Inhibitor;EGFR/ErbB-2/ErbB-4 inhibitor-2;6,7-dimethoxy-N-(4-phenylmethoxyphenyl)quinazolin-4-amine;6,7-Dimethoxy-N-[4-(phenylmethoxy)phenyl]-4-quinazolinamine;4-Quinazolinamine, 6,7-dimethoxy-N-[4-(phenylmethoxy)phenyl]-;EGFR/ErbB2/ErbB4 inhibitor2,EGFR,HER1,Inhibitor,inhibit,ErbB2,HN5,Epidermal growth factor receptor,EGFR/ErbB 2/ErbB 4 inhibitor 2,ErbB4,ErbB-1
- CBNumber:
- CB62501842
- Molecular Formula:
- C23H21N3O3
- Molecular Weight:
- 387.43
- MDL Number:
- MFCD08758375
- MOL File:
- 179248-61-4.mol
- MSDS File:
- SDS
EGFR/ErbB-2 Inhibitor price More Price(5)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 17568 | EGFR/ErbB2 Inhibitor ≥95% | 179248-61-4 | 1mg | $120 | 2024-03-01 | Buy |
Cayman Chemical | 17568 | EGFR/ErbB2 Inhibitor ≥95% | 179248-61-4 | 5mg | $477 | 2024-03-01 | Buy |
ApexBio Technology | C3285 | EGFR/ErbB2Inhibitor | 179248-61-4 | 5mg | $543 | 2021-12-16 | Buy |
ApexBio Technology | C3285 | EGFR/ErbB2Inhibitor | 179248-61-4 | 1mg | $137 | 2021-12-16 | Buy |
AK Scientific | 3569CR | EGFR/ErbB-2Inhibitor | 179248-61-4 | 1mg | $232 | 2021-12-16 | Buy |
EGFR/ErbB-2 Inhibitor Chemical Properties,Uses,Production
Uses
6,7-Dimethoxy-N-[4-(phenylmethoxy)phenyl]-4-quinazolinamine is a cell-permeable inhibitor of EFGR and c-ErbB2. This drug inhibits the proliferation of cancer cells.
Biological Activity
egfr/erbb2 inhibitor is an egfr and c-erbb2 inhibitor.egfr and c-erbb-2 are members of the epidermal growth factor receptor subfamily of protein tyrosine kinases. their cellular overexpression causes transformation, so that the cells will grow in the absence of growth factors. an inhibitor of thse kinases should block the receptor signalling, subsequent transformation and inappropriate growth.
in vitro
egfr/erbb2 inhibitor was identified as a potent inhibitor of both c-erbb-2 and egfr [ic50: 0.079 μm for c-erbb-2, 0.020 μm for egfr (isolated enzyme), 2.0 μm for hb4ac5.2 cells, 1.2 μm for bt474, both overexpressing c-erbb-2; 2.5 μm for hn5 cells overexpressing egfr]. this combined potency was contrast to smaller, previously reported anilinoquinazolines and its subsequent analogues [1].
in vivo
gw974, a analog of egfr/erbb2 inhibitor, was evaluated in the fast growing n87 gastric tumour xenograft in scid mice. results showed that gw974 at bid dose of 10 mg/kg po led to a 50% inhibition of tumour growth over the 20-day dosing period. moreover, gw974 at 10 mg/kg po bid had complete inhibition of tumour growth over the 20-day dosing period in the bt474 breast tumour xenograft model. a longer-term study with initial dosing at 30 mg/kg po bid produced tumour shrinkage [1].
IC 50
20 and 79 nm for egfr and c-erbb2, respectively
References
[1] s. cockerill, c. stubberfield, j. stables, et al. indazolylamino quinazolines and pyridopyrimidines as inhibitors of the egfr and c-erbb-2. bioorganic & medicinal chemistry letters 11, 1401-1405 (2001).
EGFR/ErbB-2 Inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
EGFR/ErbB-2 Inhibitor Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
ShangHai KenEn Chemical Technology Co., Ltd. | 13120367189 | mychess007@163.com | China | 1994 | 55 |
BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9887 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Guangzhou Younan Technology Co., Ltd | 020-020-82000279 18988968278 | sales@ubiochem.com | China | 2500 | 58 |