PRX-08066
- CAS No.
- 866206-54-4
- Chemical Name:
- PRX-08066
- Synonyms
- PRX-8066;PRX-08066;PRX08066;PRX 08066;PRX-08066, 10 mM in DMSO;5-[[4-[(6-Chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluorobenzonitrile;5-((4-((6-Chlorothieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-2-fluorobenzonitrile;Benzonitrile, 5-[[4-[(6-chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-;5-HT Receptor,5-hydroxytryptamine Receptor,Serotonin Receptor,PRX-08066,PRX 08066,PRX08066,inhibit,Inhibitor
- CBNumber:
- CB62538815
- Molecular Formula:
- C19H17ClFN5S
- Molecular Weight:
- 401.89
- MDL Number:
- MFCD20488005
- MOL File:
- 866206-54-4.mol
- MSDS File:
- SDS
| Density | 1.44 |
|---|---|
| storage temp. | Store at -20°C |
| solubility | ≥20.1 mg/mL in DMSO with ultrasonic; insoluble in H2O; ≥2.85 mg/mL in EtOH with gentle warming |
| form | solid |
| color | White to off-white |
| FDA UNII | 92E9B7675Y |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| NFPA 704 |
|
PRX-08066 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 474171 | PRX 08066 | 866206-54-4 | 100mg | $1848 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FP102683 | PRX 08066 | 866206-54-4 | 10mg | $185 | 2021-12-16 | Buy |
| ChemScene | CS-0991 | PRX-08066 97.04% | 866206-54-4 | 5mg | $190 | 2021-12-16 | Buy |
| ApexBio Technology | B1200 | PRX-08066 | 866206-54-4 | 5mg | $210 | 2021-12-16 | Buy |
| ChemScene | CS-0991 | PRX-08066 97.04% | 866206-54-4 | 10mg | $280 | 2021-12-16 | Buy |
PRX-08066 Chemical Properties,Uses,Production
Uses
PRX 08066 is a class 2 receptor antagonist which may be used in the treatment of pulmonary diseases.
Biological Activity
prx-08066 is a selective antagonist of 5-hydroxytryptamine receptor 2b (5-ht2br) with ki value of 3.4nm [1].prx-08066 is found to causes selective vasodilation of pulmonary arteries and is developed to treat for pulmonary arterial hypertension (pah). in the in vitro studies, prx-08066 shows effects on the vascular muscularization induced by 5-ht. it inhibits 5-ht induced mitogen-activated protein kinase activation with ic50 value of 12nm. in addition, it significantly reduces thymidine incorporation in cho cells expressing human 5-ht2br with ic50 value of 3nm. in both mice and rat models, prx-08066 reverses the hypoxia-dependent increase in right ventricular systolic pressure. besides that, prx-08066 is also found to have anti-proliferative and anti-fibrotic effects. it inhibits the secretion of 5-ht, the phosphorylation of erk1/2 and synthesis of profibrotic growth factor. moreover, prx-08066 inhibits the proliferation of the small intestinal neuroendocrine tumor cell line krj-i with ic50 value of 4.6nm [1, 2].
IC 50
5-HT2B Receptor: 3.4 nM (IC50)
References
[1] porvasnik s l, germain s, embury j, et al. prx-08066, a novel 5-hydroxytryptamine receptor 2b antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. journal of pharmacology and experimental therapeutics, 2010, 334(2): 364-372.
[2] svejda b, kidd m, giovinazzo f, et al. the 5-ht2b receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment. cancer, 2010, 116(12): 2902-2912.
PRX-08066 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4966 | 55 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5691 | 66 | |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10266 | 58 |
