3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole
- CAS No.
- 271576-80-8
- Chemical Name:
- 3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole
- Synonyms
- SD-06;SD 0006;SD-06-1;CS-2591;SD 0006(SD-06);SD-06;SD 06;SD06;3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole;1-(4-(5-(4-Chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl)piperidin-1-yl)-2-hydroxyethanone;Ethanone, 1-[4-[5-(4-chlorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl]-2-hydroxy-;1-(4-(5-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl)piperidin-1-yl)-2-hydroxyethan-1-one
- CBNumber:
- CB62554318
- Molecular Formula:
- C20H20ClN5O2
- Molecular Weight:
- 397.86
- MDL Number:
- MFCD17019341
- MOL File:
- 271576-80-8.mol
Boiling point | 652.6±55.0 °C(Predicted) |
---|---|
Density | 1.367 |
storage temp. | 2-8°C |
solubility | DMSO : 50 mg/mL (125.67 mM; Need ultrasonic) |
form | Powder |
pka | 9.39±0.50(Predicted) |
color | White to off-white |
FDA UNII | C57VF8YO91 |
3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Biosynth Carbosynth | FC145174 | 1-(4-(5-(4-Chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl)piperidin-1-yl)-2-hydroxyethanone | 271576-80-8 | 1mg | $280 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | KIN0001430 | SD-06 95.00% | 271576-80-8 | 1MG | $340.2 | 2021-12-16 | Buy |
ChemScene | CS-0446 | SD0006 98.60% | 271576-80-8 | 25mg | $400 | 2021-12-16 | Buy |
Biosynth Carbosynth | FC145174 | 1-(4-(5-(4-Chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl)piperidin-1-yl)-2-hydroxyethanone | 271576-80-8 | 2mg | $400 | 2021-12-16 | Buy |
AK Scientific | SYN1078 | SD-06 | 271576-80-8 | 5mg | $405 | 2021-12-16 | Buy |
3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole Chemical Properties,Uses,Production
Definition
ChEBI: SD-06 is a member of the class of pyrazoles that is 1H-pyrazole in which the hydrogens at positions 3, 4, and 5 are replaced by N-(hydroxyacetyl)piperidin-4-yl, pyrimidin-4-yl and p-chlorophenyl groups, respectively. It is a member of pyrazoles, a member of pyrimidines, a N-acylpiperidine, a member of monochlorobenzenes and a primary alcohol.
Biological Activity
SD 0006 (SD-06) is an orally potent, selective, ATP-competitive, and potent diarylpyrazole inhibitor of p38α MAPK with IC50 of 110 nM.
in vitro
SD 0006 clearly inhibits p38α as shown by the dose-dependent inhibition of phosphorylation of its endogenous Hsp27 substrate.
in vivo
SD 0006 (0-30 mg/kg) may be an effective alternative to steroids and biologics for RA therapy.It(3.75, 7.5 and 15 mg/kg; po; bid) is highly effective in attenuating SCW-induced inflammation as shown by the dose-dependent inhibition of paw swelling.
target
IC50: 110 nM (p38 MAPK).
3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Chembest Research Laboratories Limited | +86-21-20908456 | sales@BioChemBest.com | China | 6008 | 61 |
Jinan Trio PharmaTech Co., Ltd. | +86 (531) 88811783 | sales@trio-pharmatech.com (International market) | China | 1856 | 62 |