16(R)-AFP 07 (free acid)
- CAS No.
- 773825-80-2
- Chemical Name:
- 16(R)-AFP 07 (free acid)
- Synonyms
- 16(R)-AFP 07;16(R)-AFP 07 (free acid);PVHIRYQSPDZLLG-HWMGRDFZSA-N;Pentanoic acid, 5-[(3aR,4R,5R,6aS)-3,3-difluorohexahydro-5-hydroxy-4-[(1E,3R,4S)-3-hydroxy-4-methyl-1-nonen-6-ynyl]-2H-cyclopenta[b]furan-2-ylidene]-, (5Z)- (9CI);(5Z)-5-[(3aR,4R,5R,6aS)-3,3-difluoro-5-hydroxy-4-[(E,3R,4S)-3-hydroxy-4-methylnon-1-en-6-ynyl]-4,5,6,6a-tetrahydro-3aH-cyclopenta[b]furan-2-ylidene]pentanoic acid
- CBNumber:
- CB62589923
- Molecular Formula:
- C22H30F2O5
- Molecular Weight:
- 412.47
- MDL Number:
- MOL File:
- 773825-80-2.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319-H336 | |||||||||
| Precautionary statements | P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501 | |||||||||
| NFPA 704 |
|
16(R)-AFP 07 (free acid) price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10991 | 16(R)-AFP 07 (free acid) ≥98% | 773825-80-2 | 500μg | $275 | 2024-03-01 | Buy |
| Cayman Chemical | 10991 | 16(R)-AFP 07 (free acid) ≥98% | 773825-80-2 | 1mg | $521 | 2024-03-01 | Buy |
| Cayman Chemical | 10991 | 16(R)-AFP 07 (free acid) ≥98% | 773825-80-2 | 5mg | $2182 | 2024-03-01 | Buy |
| AK Scientific | 7006EC | (5E)-5-[(3Ar,4R,5R,6aS)-3,3-difluoro-5-hydroxy-4-[(E,3S,4R)-3-hydroxy-4-methylnon-1-en-6-ynyl]-4,5,6,6a-tetrahydro-3aH-cyclopenta[b]furan-2-ylidene]pentanoicacid | 773825-80-2 | 1mg | $677 | 2021-12-16 | Buy |
16(R)-AFP 07 (free acid) Chemical Properties,Uses,Production
Description
Prostaglandin I2 is an unstable prostanoid which, through the ‘I prostanoid’ (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki = 0.561 nM).1 AFP 07 shows weaker affinity for EP receptors, with Ki values > 100 nM for EP1-3 and > 10 nM for EP4.1,2 16(R)-AFP 07 is an epimer of AFP 07. Its biological properties, particularly through the IP and EP receptors, remain to be evaluated.
References
1. Chang, C.s., Negishi, M., Nakano, T., et al. 7,7-
2. Jones, R.L., and Chan, K. Distinction between relaxations induced via prostanoid EP4 and IP1 receptors in pig and rabbit blood vessels Br. J. Pharmacol. 134(2),313-324(2001).
16(R)-AFP 07 (free acid) Preparation Products And Raw materials
Raw materials
Preparation Products
16(R)-AFP 07 (free acid) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 65 |
| Shanghai Hongye Biotechnology Co. Ltd | 58 |
| MedBioPharmaceutical Technology Inc | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |