BayCysLT2
- CAS No.
- 712313-33-2
- Chemical Name:
- BayCysLT2
- Synonyms
- BayCysLT2;BayCysLT2 Exclusive;GKPAULTWHHPIHX-UHFFFAOYSA-N;Benzoic acid, 3-[[(3-carboxycyclohexyl)amino]carbonyl]-4-[3-[4-(4-phenoxybutoxy)phenyl]propoxy]-
- CBNumber:
- CB62590332
- Molecular Formula:
- C34H39NO8
- Molecular Weight:
- 589.68
- MDL Number:
- MFCD18382088
- MOL File:
- 712313-33-2.mol
BayCysLT2 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10532 | BayCysLT2 ≥95% | 712313-33-2 | 1mg | $55 | 2024-03-01 | Buy |
| Cayman Chemical | 10532 | BayCysLT2 ≥95% | 712313-33-2 | 5mg | $236 | 2024-03-01 | Buy |
| Cayman Chemical | 10532 | BayCysLT2 ≥95% | 712313-33-2 | 10mg | $420 | 2024-03-01 | Buy |
| Cayman Chemical | 10532 | BayCysLT2 ≥95% | 712313-33-2 | 25mg | $914 | 2024-03-01 | Buy |
| ApexBio Technology | C3883 | BayCysLT2 | 712313-33-2 | 25mg | $1044 | 2021-12-16 | Buy |
BayCysLT2 Chemical Properties,Uses,Production
Definition
ChEBI: Benzoic acid, 3-[[(3-carboxycyclohexyl)amino]carbonyl]-4-[3-[4-(4-phenoxybutoxy)phenyl]propoxy]- is an organooxygen compound and an organonitrogen compound. It is functionally related to a gamma-amino acid.
Biological Activity
baycyslt2, an isophthalic acid derivative, is a selective and potent cyslt2 receptor antagonist [1].cysteinyl leukotrienes (cyslts) belong to a family of g protein-coupled receptors (gpcrs). the cysteinyl leukotrienes (cyslts) are inflammatory mediators associated with neuronal injury after brain ischemia through the activation of their receptors, cyslt1r and cyslt2r [2].
in vitro
baycyslt2 inhibited radioligand binding of ltd4 to cyslt2 and cyslt1 receptor cell lines with ic50 values of 35 and >10,000 nm, respectively [1]. baycyslt2 reversed ltc4-stimulated perfusion pressure increase and contractility decrease in isolated langendorff-perfused guinea pig hearts in a concentration-dependent manner [1]. baycyslt2 protected astrocytes from ischemic injury [3].
in vivo
baycyslt2 attenuated myocardial infarction damage but also inhibited ltd4-induced evans blue dye leakage in the mouse ear vasculature [4].
References
[1] m. harter, j. erguden, f. wunder, et al. isophtalic acid derivatives. 10/537,623, 1-104 (2006).
[2] takasaki j, kamohara m, matsumoto m, et al. the molecular characterization and tissue distribution of the human cysteinyl leukotriene cyslt 2 receptor[j]. biochemical and biophysical research communications, 2000, 274(2): 316-322.
[3] x. j. huang, w.p. zhang, c.t. li, w.z. shi, s.h. fang, y.b. lu, z. chen, e.q. wei. activation of cyslt receptors induces astrocyte proliferation and death after oxygen–glucose deprivation. glia, 56 (2008), pp. 27–37
[4] n. c. ni, d. yan, l.l. ballantyne, a. barajas-espinosa st, t. amand, d.a. pratt, c.d. funk. a selective cysteinyl leukotriene receptor 2 antagonist blocks myocardial ischemia/reperfusion injury and vascular permeability in mice. j. pharmacol. exp. ther., 339 (2011), pp. 768–778
BayCysLT2 Preparation Products And Raw materials
Raw materials
Preparation Products
BayCysLT2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
| ApexBio Technology | 58 |