Genz-123346
- CAS No.
- 491833-30-8
- Chemical Name:
- Genz-123346
- Synonyms
- CS-1436;Genz-123346;Eliglustat Impurity 7;Genz-123346 (free base);Genz-123346 free base, 10 mM in DMSO;GENZ-123346; GENZ123346; GENZ 123346;Glucosylceramide Synthase Inhibitor, Genz-123346;N-((1R,2R)-1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)no;Inhibitor,Genz 123346 free base,Genz-123346,Genz123346 free base,Genz 123346,inhibit,Genz123346;N-[(1R,2R)-2-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-2-HYDROXY-1-(1-PYRROLIDINYLMETHYL)ETHYL]-NONANAMIDE
- CBNumber:
- CB62599133
- Molecular Formula:
- C24H38N2O4
- Molecular Weight:
- 418.57
- MDL Number:
- MFCD22419854
- MOL File:
- 491833-30-8.mol
| Boiling point | 623.9±55.0 °C(Predicted) |
|---|---|
| Density | 1.111±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:84.0(Max Conc. mg/mL);200.68(Max Conc. mM) Ethanol:84.0(Max Conc. mg/mL);200.68(Max Conc. mM) |
| form | A crystalline solid |
| pka | 13.45±0.20(Predicted) |
| color | White to off-white |
| FDA UNII | 8JW4ZYR2CT |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Genz-123346 price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28500 | Genz-123346 | 491833-30-8 | 50mg | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 28500 | Genz-123346 | 491833-30-8 | 100mg | $243 | 2024-03-01 | Buy |
| AK Scientific | 3693AH | Genz-123346 | 491833-30-8 | 50mg | $241 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 95164 | GENZ-123346 | 491833-30-8 | 100mg | $490 | 2021-12-16 | Buy |
| AK Scientific | 3693AH | Genz-123346 | 491833-30-8 | 100mg | $370 | 2021-12-16 | Buy |
Genz-123346 Chemical Properties,Uses,Production
Uses
GENZ-123346 potently controls hyperglycemia in obese rodent models of insulin resistance.
Biological Activity
Cell permeable: yes', 'Primary Target
glucosylceramide synthase', 'Reversible: yes', 'Target IC50: 14 nM for ganglioside GM1 suppression
in vivo
In the Zucker diabetic fatty rat, Genz-123346 loared glucose and A1C levels and improved glucose tolerance. Drug treatment also prevented the loss of pancreatic beta-cell function and preserved the ability of the animals to secrete insulin. In the diet-induced obese mouse, treatment with Genz-123346 normalized A1C levels and improved glucose tolerance. The oral bioavailability of the drug is shown to be about 10% and 30% in mice and rats, respectively, with a half-life in plasma of 30–60 min[1]. Genz-123346 treatment results in a dose-dependent reduction of renal GlcCer and GM3 levels that translates into effective inhibition of cystic disease. A direct effect of Genz-123346 on the Akt-mTOR signaling pathway is observed, with reduced phosphorylation of Akt and ribosomal protein S6[4].
Genz-123346 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30231 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15395 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20235 | 58 |
View Lastest Price from Genz-123346 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Genz-123346 free base
491833-30-8
|
US $43.00-126.00 / mg | 99.23% | 10g | TargetMol Chemicals Inc. |
-
- Genz-123346 free base
491833-30-8
- US $43.00-126.00 / mg
- 99.23%
- TargetMol Chemicals Inc.