5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate
![5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate Structure](CAS/GIF/52248-03-0.gif)
- CAS No.
- 52248-03-0
- Chemical Name:
- 5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate
- Synonyms
- VHPOFDUCFKOUHV-XKGORWRGSA-O;S-(5'-Adenosyl)-L-methionine tosylate;S-(5''-Adenosyl)-L-methionine tosylate;P-toluenesulfonic acid adenosylmethionine;P-toluenesulfonic acid adenosylmethionine (SAMe);S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt;S-(5''-Adenosyl)-L-methionine tosylate, 10 mM in DMSO;S-(5′-Adenosyl)-
L -methionine p-toluenesulfonate salt;5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate;S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt >=80% (HPLC), >=80% (spectrophotometric assay)
- CBNumber:
- CB62616975
- Molecular Formula:
- C22H30N6O8S2
- Molecular Weight:
- 570.64
- MDL Number:
- MFCD00063498
- MOL File:
- 52248-03-0.mol
- MSDS File:
- SDS
| Melting point | 78℃ |
|---|---|
| storage temp. | -20°C |
| solubility | DMF: 5 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 10 mg/ml |
| form | A crystalline solid |
| color | White to yellow |
| biological source | synthetic (Organic) |
| Water Solubility | H2O: 100mg/mL |
| UNSPSC Code | 12352209 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A2408 | S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt ≥80% (HPLC), ≥80% (spectrophotometric assay) | 52248-03-0 | 25mg | $93.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | A2408 | S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt ≥80% (HPLC), ≥80% (spectrophotometric assay) | 52248-03-0 | 100mg | $190 | 2024-03-01 | Buy |
| Cayman Chemical | 16376 | S-(5''-Adenosyl)-L-methionine (tosylate) | 52248-03-0 | 50mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 16376 | S-(5'-Adenosyl)-L-methionine (tosylate) | 52248-03-0 | 500mg | $632 | 2024-03-01 | Buy |
| Sigma-Aldrich | A2408 | S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt ≥80% (HPLC), ≥80% (spectrophotometric assay) | 52248-03-0 | 500mg | $691 | 2024-03-01 | Buy |
5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate Chemical Properties,Uses,Production
Uses
S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt has been used for cell proliferation assay. It has also been used for methylation assay.
General Description
S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt is used for the treatment of depression, liver cirrhosis, cholestasis and degenerative joint disease.
Biochem/physiol Actions
Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
in vivo
Mice lacking methionine adenosyltransferase 1a (Mat1a) have reduced hepatic S-Adenosyl-L-methionine levels and develop oxidative stress, steatohepatitis, and hepatocellular carcinoma (HCC).? However, injury and HCC also occur if hepatic S-Adenosyl-L-methionine level is excessive chronically. Thus a normal hepatic S-Adenosyl-L-methionine level is necessary to maintain liver health and prevent injury and HCC[3].
IC 50
Human Endogenous Metabolite
5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate Preparation Products And Raw materials
Raw materials
Preparation Products
5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 9985 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Syncozymes (Shanghai) Co.,Ltd. | 021-68187180-819 13681683526 | lchen@syncozymes.com | China | 254 | 55 |
| Beijing Qinling Mountains Pharmaceutical Co., Ltd. | 010-61241352 18901327973 | 834537306@qq.com | China | 530 | 58 |