OT-R antagonist 1
- CAS No.
- 364071-17-0
- Chemical Name:
- OT-R antagonist 1
- Synonyms
- OT-R antagonist 1;LS-192629（OT-R antagonist 1）;Oxytocin receptor antagonist 1;2-PyrrolidinecarboxaMide, N-[(2S)-2-hydroxy-2-phenylethyl]-4-(MethoxyiMino)-1-[(2'-Methyl[1,1'-biphenyl]-4-yl)carbonyl]-, (2S,4Z)-
- CBNumber:
- CB62626741
- Molecular Formula:
- C28H29N3O4
- Molecular Weight:
- 471.55
- MDL Number:
- MOL File:
- 364071-17-0.mol
OT-R antagonist 1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-5583 | OT-Rantagonist1 >98.0% | 364071-17-0 | 1mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-5583 | OT-Rantagonist1 >98.0% | 364071-17-0 | 5mg | $1188 | 2021-12-16 | Buy |
| ChemScene | CS-5583 | OT-Rantagonist1 >98.0% | 364071-17-0 | 10mg | $1980 | 2021-12-16 | Buy |
| Crysdot | CD31002086 | OT-Rantagonist1 98+% | 364071-17-0 | 5mg | $686 | 2021-12-16 | Buy |
| Crysdot | CD31002086 | OT-Rantagonist1 98+% | 364071-17-0 | 10mg | $1146 | 2021-12-16 | Buy |
OT-R antagonist 1 Chemical Properties,Uses,Production
Biological Activity
OT-R antagonist 1 is a new potent and selective nonpeptide low molecular weight OT-R antagonist. It inhibits oxytocin-evoked intracellular Ca2+ mobilization (IC50 = 8 nM).
in vitro
OT-R antagonist 1 inhibitis IP3-Synthesis, rat OT-R (IC50=0.03 uM). OT-R antagonist 1 inhibits phosphodiesterase IV with IC50 = 6.1 μM, a value about 300-fold higher than the affinity for OT-R. OT-R antagonist 1 shows a very clean selectivity profile with specific interaction with OT-R. OT-R antagonist 1 competitively inhibits binding of [3H]oxytocin and the peptide antagonist 125I-ornithine vasotocin analog to human and rat oxytocin receptor expressed in human embryonic kidney 293-EBNA or Chinese hamster ovary cells with nanomolar potency. Selectivity against vasopressin receptor subtypes is >6-fold for V1a and >350-fold for V2 and V1b.
in vivo
Oxytocininduced contraction of isolated rat uterine strips is blocked by OT-R antagonist 1 (pA2 = 7.82). In anesthetized nonpregnant rats, single administration of OT-R antagonist 1 by i.v. or oral routes causes dose-dependent inhibition of contractions elicited by repeated injections of oxytocin with ED50 = 3.5 mg/kg i.v. and 89 mg/kg p.o., respectively. OT-R antagonist 1 significantly inhibits spontaneous uterine contractions in pregnant rats near term when administered intravenously or orally.
OT-R antagonist 1 Preparation Products And Raw materials
Raw materials
Preparation Products
OT-R antagonist 1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8014 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9887 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 890 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
| Beijing xinyanhui pharmaceutical research and development co., LTD | 13969155946 | 1461866103@qq.com | China | 16111 | 58 |