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NSC 42834

NSC 42834 Structure
NSC 42834 structure
CAS No.
195371-52-9
Chemical Name:
NSC 42834
Synonyms
NSC 42834;1-Butanone;NSC 42834，Z3;Z3(NSC 42834);JAK2 Inhibitor V;NSC 42834,Z3, >95%;JAK2 Inhibitor V, Z3;JAK2 Inhibitor V Z3|||Z3;JAK2 Inhibitor V, Z3, >=98%;NSC 42834 (JAK2 INHIBITOR V)
CBNumber:
CB62645144
Molecular Formula:
C23H24N2O
Molecular Weight:
344.45
MDL Number:
MFCD00023550
MOL File:
195371-52-9.mol
Last updated:2025-04-17 18:22:24
Request For Quotation

NSC 42834 Properties

Boiling point 520.4±50.0 °C(Predicted)
Density 1.106±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
form Powder
pka 5.90±0.12(Predicted)
color Colorless to light yellow
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS02
Signal word  Danger

NSC 42834 price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 420141 JAK2 Inhibitor V, Z3 - CAS 195371-52-9 - Calbiochem 195371-52-9 10MG $154 2023-01-07 Buy
Cayman Chemical 17684 JAK2 Inhibitor V ≥95% 195371-52-9 1mg $32 2024-03-01 Buy
Cayman Chemical 17684 JAK2 Inhibitor V ≥95% 195371-52-9 5mg $78 2024-03-01 Buy
Cayman Chemical 17684 JAK2 Inhibitor V ≥95% 195371-52-9 10mg $122 2024-03-01 Buy
Cayman Chemical 17684 JAK2 Inhibitor V ≥95% 195371-52-9 25mg $267 2024-03-01 Buy
Product number Packaging Price Buy
420141 10MG $154 Buy
17684 1mg $32 Buy
17684 5mg $78 Buy
17684 10mg $122 Buy
17684 25mg $267 Buy

NSC 42834 Chemical Properties,Uses,Production

Uses

NSC 42834 (JAK2 Inhibitor V), a novel specific inhibitor of Jak2, inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity.

IC 50

JAK2-WT: 15 μM (IC50); JAK2-V617F: 28 μM (IC50)

References

[1] Jacqueline Sayyah, Andrew Magis, David A. Ostrov, et al. Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth . Mol Cancer Ther 2008;7(8):2308-18.
[2] Jacqueline Sayyah, Peter P. Sayeski. Jak2 inhibitors: Rationale and role as therapeutic agents in hematologic malignancies. Current Oncology Reports. 2009, 11(2): 117-124.
[3] Ehab Atallah , Srdan Verstovsek . Prospect of JAK2 inhibitor therapy in myeloproliferative neoplasms. Expert Review of Anticancer Therapy. 2009,9 (5):663-670.

NSC 42834 Preparation Products And Raw materials

Raw materials

Preparation Products

NSC 42834 Suppliers

Global( 85)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29858 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Alchem Pharmtech,Inc. 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Aladdin Scientific 		58

View Lastest Price from NSC 42834 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JAK2 Inhibitor V pictures 2024-11-19 JAK2 Inhibitor V
195371-52-9
 US $33.00-77.00 / mg 99.15% 10g TargetMol Chemicals Inc.
2-METHYL-1-PHENYL-4-(PYRIDIN-2-YL)-2-(2-(PYRIDIN-2-YL)ETHYL)BUTAN-1-ONE pictures 2019-09-05 2-METHYL-1-PHENYL-4-(PYRIDIN-2-YL)-2-(2-(PYRIDIN-2-YL)ETHYL)BUTAN-1-ONE
195371-52-9
 US $1.00 / ASSAYS 1ASSAYS 98% 10kg Career Henan Chemical Co

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1of4

JAK2 Inhibitor V, Z3 NSC 42834 1-Butanone, 2-Methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]- 2-METHYL-1-PHENYL-4-(PYRIDIN-2-YL)-2-(2-(PYRIDIN-2-YL)ETHYL)BUTAN-1-ONE 2-Methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]-1-butanone NSC 42834 2-Methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]-1-butanone JAK2 Inhibitor V, Z3, >=98% JAK2 Inhibitor V NSC 42834 Z 3 2-Methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]-1-butanone Z3(NSC 42834) 1-Butanone 2-methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]- Z3;NSC 42834;1-BUTANONE; 2-METHYL-1-PHENYL-4-(2-PYRIDINYL)-2-[2-(2-PYRIDINYL)ETHYL]- NSC 42834 (JAK2 INHIBITOR V) NSC 42834(JAK2 Inhibitor V, Z3) NSC 42834,Z3, >95% NSC 42834，Z3 NSC42834,Z 3,NSC-42834,Janus kinase,NSC 42834,Z-3,Inhibitor,JAK,inhibit JAK2 Inhibitor V Z3|||Z3 JAK2 Inhibitor V, 10 mM in DMSO 195371-52-9 Inhibitors