ZP 1609 Hydrochloride
- CAS No.
- 943133-81-1
- Chemical Name:
- ZP 1609 Hydrochloride
- Synonyms
- GAP134 Hydrochloride;ZP1609 Hydrochloride;ZP-1609 Hydrochloride;ZP 1609 Hydrochloride;GAP 134 Hydrochloride;GAP-134 (Hydrochloride);Danegaptide Hydrochloride;GAP-134 HYDROCHLORIDE, >98%;Danegaptide hydrochloride salt;Danegaptide (GAP-134) hydrochloride
- CBNumber:
- CB62666622
- Molecular Formula:
- C14H18ClN3O4
- Molecular Weight:
- 327.76342
- MDL Number:
- MFCD23160032
- MOL File:
- 943133-81-1.mol
ZP 1609 Hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1101 | DanegaptideHydrochloride 99.75% | 943133-81-1 | 5mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-1101 | DanegaptideHydrochloride 99.75% | 943133-81-1 | 10mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-1101 | DanegaptideHydrochloride 99.75% | 943133-81-1 | 25mg | $500 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611743 | GAP-134 hydrochloride | 943133-81-1 | 10mg | $598.4 | 2021-12-16 | Buy |
| ChemScene | CS-1101 | DanegaptideHydrochloride 99.75% | 943133-81-1 | 50mg | $750 | 2021-12-16 | Buy |
ZP 1609 Hydrochloride Chemical Properties,Uses,Production
Description
GAP-134 Hcl (Danegaptide, ZP 1609), a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability. IC50 value: Target: gap junction Gap junction uncoupling can alter conduction pathways and promote cardiac re-entry mechanisms that potentiate many supraventricular arrhythmias, such as atrial fibrillation (AF) and atrial flutter (AFL). Gap junction modifier GAP-134, showed consistent efficacy on measures of conduction and AF/AFL inducibility in the canine sterile pericarditis model. GAP-134 is a pharmalogical agent with a favorable clinical safety profile and potential antiarrhythmic efficacy, as already confirmed in phase I clinical trials.
References
References:[1]. De Vuyst E, Boengler K, Antoons G, et al. Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol. 2011 Jun;163(3):469-83. [2]. Laurent G, Leong-Poi H, Mangat I, et al. Effects of chronic gap junction conduction-enhancing antiarrhythmic peptide GAP-134 administration on experimental atrial fibrillation in dogs. Circ Arrhythm Electrophysiol. 2009 Apr;2(2):171-8. [3]. Hennan JK, Swillo RE, Morgan GA, et al. GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs. J Cardiovasc Pharmacol Ther. 2009 Sep;14(3):207-14. [4]. Rossman EI, Liu K, Morgan GA, et al. The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model. J Pharmacol Exp Ther. 2009 Jun;329(3):1127-33. [5]. Eugene L. Piatnitski Cheklera, John A. Buterab, Li Dib, Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents. Bioorganic & Medicinal Chemistry Letters. 2009,19(16): 4551-4554
ZP 1609 Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
ZP 1609 Hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2989 | 60 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3868 | 58 |