Kalydeco benzenesulfonate
- CAS No.
- 1134822-09-5
- Chemical Name:
- Kalydeco benzenesulfonate
- Synonyms
- VX770 benzenesulfonate;VX-770 benzenesulfonate;VX 770 benzenesulfonate;Kalydeco benzenesulfonate;Ivacaftor (benzenesulfonate);Ivacaftor benzenesulfonate (VX770);Ivacaftor benzenesulfonate (VX-770 benzenesulfonate;N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide.besylate
- CBNumber:
- CB62666642
- Molecular Formula:
- C30H34N2O6S
- Molecular Weight:
- 550.67
- MDL Number:
- MFCD26960946
- MOL File:
- 1134822-09-5.mol
Kalydeco benzenesulfonate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A100828 | IvacaftorBenzenesulfonate | 1134822-09-5 | 1mg | $45 | 2021-12-16 | Buy |
| TRC | A100828 | IvacaftorBenzenesulfonate | 1134822-09-5 | 2mg | $65 | 2021-12-16 | Buy |
| TRC | A100828 | IvacaftorBenzenesulfonate | 1134822-09-5 | 10mg | $265 | 2021-12-16 | Buy |
| ApexBio Technology | A3510 | Ivacaftorbenzenesulfonate | 1134822-09-5 | 25mg | $250 | 2021-12-16 | Buy |
| ApexBio Technology | A3510 | Ivacaftorbenzenesulfonate | 1134822-09-5 | 100mg | $650 | 2021-12-16 | Buy |
Kalydeco benzenesulfonate Chemical Properties,Uses,Production
Uses
Ivacaftor Benzenesulfonate is a salt of Ivacaftor, a novel agent for the treatment of cystic fibrosis.
Biological Activity
ivacaftor (vx-770) is a cftr potentiator approved for patients with the g551d mutation of cystic fibrosis, which accounts for 4-5% cases of cystic fibrosis.
in vitro
in recombinant cells vx-770 increased cftr channel open probability (p(o)) in both the f508del processing mutation and the g551d gating mutation. vx-770 also increased cl(-) secretion in cultured human cf bronchial epithelia (hbe) carrying the g551d gating mutation on one allele and the f508del processing mutation on the other allele by approximately 10-fold, to approximately 50% of that observed in hbe isolated from individuals without cf [1].
in vivo
at day 28, in the group of subjects who received 150 mg of vx-770, the median change in the nasal potential difference (in response to the administration of a chloride-free isoproterenol solution) from baseline was -3.5 mv (range, -8.3 to 0.5; p=0.02 for the within-subject comparison, p=0.13 vs. placebo), and the median change in the level of sweat chloride was -59.5 mmol per liter (range, -66.0 to -19.0; p=0.008 within-subject, p=0.02 vs. placebo) [2].
IC 50
25 nm (f508del-cftr);100 nm (g551d-cftr) [1]
Kalydeco benzenesulfonate Preparation Products And Raw materials
Raw materials
Preparation Products
Kalydeco benzenesulfonate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| ShangHai Onsyn-Chemical Technology Co., Ltd. | 021-58359326 13124831025 | angsihuaxue@126.com | China | 246 | 55 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 58 |
| InvivoChem | 58 |
| Amadis Chemical Company Limited | 58 |
| BOC Sciences | 65 |
| ShangHai Onsyn-Chemical Technology Co., Ltd. | 55 |
| LETOPHARM LIMITED | 58 |
| SPIRO PHARMA | 55 |
| ShangHai Biochempartner Co.,Ltd | 62 |
| Musechem | 60 |