AZD3839
- CAS No.
- 1227163-56-5
- Chemical Name:
- AZD3839
- Synonyms
- AZD3839;(Rac)-AZD3839;AZD-3839;AZD 3839;4-Fluoro-1-[3-(5-pyrimidinyl)phenyl]-1-[2-(trifluoromethyl)-4-pyridinyl]-1H-isoindol-3-amine;4-Fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine;1H-Isoindol-3-amine, 4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-1-[2-(trifluoromethyl)-4-pyridinyl]-
- CBNumber:
- CB62667311
- Molecular Formula:
- C24H15F4N5
- Molecular Weight:
- 449.4
- MDL Number:
- MOL File:
- 1227163-56-5.mol
| Boiling point | 574.9±60.0 °C(Predicted) |
|---|---|
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20° C |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 2.47±0.40(Predicted) |
| FDA UNII | I8ID590133 |
AZD3839 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A808145 | AZD3839 | 1227163-56-5 | 50mg | $875 | 2021-12-16 | Buy |
| ApexBio Technology | B3224 | AZD3839 | 1227163-56-5 | 50mg | $1103 | 2021-12-16 | Buy |
| ApexBio Technology | B3224 | AZD3839 | 1227163-56-5 | 5mg | $205 | 2021-12-16 | Buy |
| ApexBio Technology | B3224 | AZD3839 | 1227163-56-5 | 10mg | $315 | 2021-12-16 | Buy |
| ApexBio Technology | B3224 | AZD3839 | 1227163-56-5 | 25mg | $630 | 2021-12-16 | Buy |
AZD3839 Chemical Properties,Uses,Production
Uses
AZD3839 is a potent and selective inhibitor of human Beta-secretase 1 (BACE1).
Biological Activity
azd3839 is a novel inhibitor of bace1 with ic50 value of 4.8μm [1].azd3839 has been reported to inhibit human bace1 activity in a biochemical fret assay. in addition, azd3839 has also been reported to inhibit the release of sappβs from human sh-sy5y cells, mouse n2a cells and mouse and guinea pig primary cortical neurons. moreover, azd3839 has been revealed to effectively decrease the cerebrospinal fluid (csf), plasma, and brain aβ levels in guinea pig, mouse and non-human primate. azd3839 has also been revealed to decrease the levels of aβ40 secreted from c57bl/6 mouse primary cortical neurons, n2a cells (mouse neuroblastoma), and dunkin-hartley guinea pig primary cortical neurons, with ic50 values of 50.9, 32.2, and 24.8 nmol/liter, respectively [2].
target
BACE1
References
[1] sparve e1, quartino al1, luttgen m1, tunblad k1, teiling-gardlund a1, falting j1, alexander r1, kagstrom j1, sjodin l1, bulgak a1, al-saffar a1, bridgland-taylor m2, pollard c3, swedberg md4, vik t5, paulsson b1. prediction and modeling of effects on the qtc interval for clinical safety margin assessment, based on single ascending dose study data with azd3839. j pharmacol exp ther. 2014 jun 10.
[2] jeppsson f1, eketjäll s, janson j, karlström s, gustavsson s, olsson ll, radesäter ac, ploeger b, cebers g, kolmodin k, swahn bm, von berg s, bueters t, fälting j. discovery of azd3839, a potent and selective bace1 inhibitor clinical candidate for the treatment of alzheimer disease. j biol chem. 2012 nov 30;287(49):41245-57.
AZD3839 Preparation Products And Raw materials
Raw materials
Preparation Products
AZD3839 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2782 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Taizhou Crene Biotechnology Co. Ltd. | +86-0576-88813233 +86-13396860566 | sales@pharm-intermediates.com | China | 1990 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | wulan@absin.cn | China | 24731 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44808 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Abmole Bioscience Inc. | 021-50967598 02150967598 | sales@abmole.cn | China | 4494 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6251 | 58 |