ChemicalBook >> CAS DataBase List >>BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)-

BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)-

CAS No.
174227-14-6
Chemical Name:
BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)-
Synonyms
Bosentan USP RC B;Bosentan IMpurity D;Bosentan EP Impurity-B;O-Deshydroxyethyl Bosentan;Bosentan Related CoMpound B;Bosentan USP Related Compound B;Bosentan Related Compound B (O-Deshydroxyethyl Bosentan);4-(tert-butyl)-N-(6-hydroxy-5-(2-methoxyphenoxy)-[2,2-bipyrimidin]-4-yl)benzenesulfonamide;p-tert-butyl-N-[6-(hydroxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzene sulfonamide;4-(tert-butyl)-N-(6-hydroxy-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
CBNumber:
CB62667876
Molecular Formula:
C25H25N5O5S
Molecular Weight:
507.56
MDL Number:
MFCD25977341
MOL File:
174227-14-6.mol
Last updated:2023-05-29 08:28:42

BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)- Properties

Melting point >218°C (dec.)
Boiling point 690.0±65.0 °C(Predicted)
Density 1.34±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility DMSO (Slightly), Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 4.48±0.50(Predicted)
color Pale Beige to Light Beige
FDA UNII 9B7A5GJ8V8

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
HS Code  2935909550

BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)- price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D290485 O-DeshydroxyethylBosentan 174227-14-6 500mg $1390 2021-12-16 Buy
Biosynth Carbosynth FD64077 O-Deshydroxyethyl bosentan 174227-14-6 10mg $650 2021-12-16 Buy
Biosynth Carbosynth FD64077 O-Deshydroxyethyl bosentan 174227-14-6 25mg $950 2021-12-16 Buy
Biosynth Carbosynth FD64077 O-Deshydroxyethyl bosentan 174227-14-6 1mg $120 2021-12-16 Buy
Biosynth Carbosynth FD64077 O-Deshydroxyethyl bosentan 174227-14-6 2mg $200 2021-12-16 Buy
Product number Packaging Price Buy
D290485 500mg $1390 Buy
FD64077 10mg $650 Buy
FD64077 25mg $950 Buy
FD64077 1mg $120 Buy
FD64077 2mg $200 Buy

BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)- Chemical Properties,Uses,Production

Uses

O-Deshydroxyethyl Bosentan (Bosentan USP Related Compound B) is an impurity of Bosentan (B675900); a mixed endothelin receptor antagonist. Used as a vasodilator and antihypertensive.

150727-06-3
174227-14-6
Synthesis of BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)- from 4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide

BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)- Bosentan USP RC B Bosentan IMpurity D Bosentan Related CoMpound B N-[1,6-Dihydro-5-(2-methoxyphenoxy)-6-oxo[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)benzenesulfonamide Bosentan Related Compound B (15 mg) (4-(tert-butyl)-N-[6-hydroxy-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl]benzenesulfonamide) O-Deshydroxyethyl Bosentan Bosentan USP Related Compound B: 4-(tert-Butyl)-N-[6-hydroxy-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl]benzenesulfonamide Bosentan USP Related Compound B p-tert-butyl-N-[6-(hydroxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzene sulfonamide 4-(tert-butyl)-N-(6-hydroxy-5-(2-methoxyphenoxy)-[2,2-bipyrimidin]-4-yl)benzenesulfonamide Bosentan Related Compound B (O-Deshydroxyethyl Bosentan) Bosentan Related Compound B (4-(tert-butyl)-N-[6-hydroxy-5-(2-methoxyphenoxy)-(2,2''-bipyrimidin)-4- (1076137) Bosentan EP Impurity-B 4-(tert-butyl)-N-(6-hydroxy-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide 174227-14-6 C25H25N5O5S