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Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]-

Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- structure

CAS No.: 870544-59-5

Chemical Name:: Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]-

Synonyms: BPTU;CS-2758;BMS-646786;BPTU, 10 mM in DMSO;P2Y Antagonist II, BPTU;1-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea;BPTU,antithrombotic,thrombosis,BMS 646786,P2Y Receptor,inhibit,BMS646786,Inhibitor;N-[2-[2-(1,1-Dimethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoromethoxy)phenyl]urea;Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]-

CBNumber:: CB62668237

Molecular Formula:: C23H22F3N3O3

Molecular Weight:: 445.43

MDL Number:: MFCD28386231

MOL File:: 870544-59-5.mol

Last updated:2025-04-17 18:22:24

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Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- Properties

Boiling point	426.3±45.0 °C(Predicted)
Density	1.307±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:34.29(Max Conc. mg/mL);76.98(Max Conc. mM) DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.67(Max Conc. mM) DMF:15.0(Max Conc. mg/mL);33.67(Max Conc. mM) Ethanol:29.77(Max Conc. mg/mL);66.83(Max Conc. mM)
form	A solid
pka	12.59±0.70(Predicted)
color	White to off-white
UNSPSC Code	12352200
NACRES	NA.77

Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	29444	BPTU	870544-59-5	1mg	$32	2024-03-01	Buy
Cayman Chemical	29444	BPTU	870544-59-5	5mg	$78	2024-03-01	Buy
Cayman Chemical	29444	BPTU	870544-59-5	10mg	$139	2024-03-01	Buy
Cayman Chemical	29444	BPTU	870544-59-5	25mg	$267	2024-03-01	Buy
Tocris	6078	BPTU ≥98%(HPLC)	870544-59-5	10	$219	2021-12-16	Buy

Product number	Packaging	Price	Buy
29444	1mg	$32	Buy
29444	5mg	$78	Buy
29444	10mg	$139	Buy
29444	25mg	$267	Buy
6078	10	$219	Buy

Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- Chemical Properties,Uses,Production

Uses

BPTU is a non-nucleotide antagonist of P2Y1 receptor. It blocks nerve mediated inhibitory neuromuscular responses in the gastrointestinal tract of rodents.

Biological Activity

Primary Target
P2Y1', 'Reversible: yes

in vivo

Uptake of BPTU from the peritoneal cavity is relatively rapid. Blood boron levels are maximal within 1 h after administration. After only 1 h, a boron tumor-to-blood ratio above 1 is found for BPTU in pigmented tumors, which is indicative of drug retention. This is not seen in the non-pigmented tumor variant, in which tumor boron levels closely follow blood levels. Up to 24 h, Borocaptate sodium (BSH) exhibits no selective retention in either tumor, but achieves higher maximum tumor boron concentrations than BPTU as a result of the administration of higher amounts of boron. During the tissue distribution phase, liver-to-kidney boron concentration ratios range from 2 to 4 for BSH and from 0.5 to 1 for BPTU^[2].

IC 50

P2Y1 Receptor

storage

Store at RT

Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- Suppliers

Global( 59)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29808	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	+86-86-22-87899925 +86-8618522618860	18522618860@163.com	China	694	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38630	58
Chemtour Biotech Co., Ltd	+8617327281506	market@chemtour.com	China	1521	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	58
TargetMol Chemicals Inc.	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Chemtour Biotech Co., Ltd	58
Aladdin Scientific	58

View Lastest Price from Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	BPTU 870544-59-5	US $32.00-66.00 / mg		99.89%	10g	TargetMol Chemicals Inc.
	2019-12-25	Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- 870544-59-5	US $1.00 / g	1g	99.99%	200kg	Career Henan Chemical Co

BPTU
870544-59-5
US $32.00-66.00 / mg
99.89%
TargetMol Chemicals Inc.

Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]-
870544-59-5
US $1.00 / g
99.99%
Career Henan Chemical Co

Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- BPTU 1-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea N-[2-[2-(1,1-Dimethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoromethoxy)phenyl]urea CS-2758 BMS-646786 BPTU,antithrombotic,thrombosis,BMS 646786,P2Y Receptor,inhibit,BMS646786,Inhibitor BPTU, 10 mM in DMSO P2Y Antagonist II, BPTU 870544-59-5 API