Necrosulfonamide
- CAS No.
- 1360614-48-7
- Chemical Name:
- Necrosulfonamide
- Synonyms
- 100318;CS-2351;NecrosulfonaMide;(E)-NECROSULFONAMIDE;(Z)-Necrosulfonamide;Necrosulfonamide (NSA);(2Z)-N-{4-[(3-Methoxy-2-pyrazinyl)sulfamoyl]phenyl}-3-(5-nitro-2-thienyl)acrylamide;(E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfaMoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylaMide;(2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide;2-Propenamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-, (2E)-
- CBNumber:
- CB62669623
- Molecular Formula:
- C18H15N5O6S2
- Molecular Weight:
- 461.47
- MDL Number:
- MFCD02370191
- MOL File:
- 1360614-48-7.mol
| Melting point | 200-204°C(dec.) |
|---|---|
| Density | 1.578±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 10 mg/ml) |
| form | solid |
| pka | 6.37±0.40(Predicted) |
| color | Yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Necrosulfonamide price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20844 | Necrosulfonamide ≥95% | 1360614-48-7 | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 20844 | Necrosulfonamide ≥95% | 1360614-48-7 | 10mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 20844 | Necrosulfonamide ≥95% | 1360614-48-7 | 25mg | $216 | 2024-03-01 | Buy |
| Cayman Chemical | 20844 | Necrosulfonamide ≥95% | 1360614-48-7 | 50mg | $356 | 2024-03-01 | Buy |
| Tocris | 5025 | Necrosulfonamide ≥98%(HPLC) | 1360614-48-7 | 50 | $458 | 2021-12-16 | Buy |
Necrosulfonamide Chemical Properties,Uses,Production
Description
Necrosulfonamide (1360614-48-7) specifically blocks necroptosis downstream of RIP3 activation by preventing MLKL-RIP3 interaction.1 Displays neuroprotective effects after ischemic brain injury.2 Prevents cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells.3 Binds to gasdermin D inhibiting pyroptosis and associated inflammatory cell death and sepsis.4 Rescues cells from TLR3 ligand-induced death.5
Uses
Necrosulfonamide is a necroptosis inhibitor. Necrosulfonamide is a pharmacological inhibitor of mixed lineage kinase domain-like protein (MLKL).
Definition
ChEBI: Necrosulfonamide is a sulfonamide that is a 3-methoxypyrazin-2-yl derivative of (E)-N-(4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide. Necrosulfonamide specifically blocks necrosis downstream of the activation of RIP3 (the receptor-interacting serine-threonine kinase 3), a key signalling molecule in the programmed necrosis (necroptosis) pathway. It is a sulfonamide, a member of pyrazines and a member of thiophenes.
storage
Store at +4°C
References
1) Sun et al. (2012) Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase; Cell 148 213 2) Zhou et al. (2017) The degradation of mixed linage kinase domain-like protein promotes neuroprotection after ischemic brain injury; Oncotarget, 8 68393 3) Chen et al. (2017) CHAC1 degradation of glutathione enhances cysteine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-elF2α-ATF4 pathway; Oncotarget, 8 114588 4) Rathkey et al. (2018) Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis; Sci Immunol., 3 eaat2738 5) Cuchet-Lourenco et al. (2018) Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation; Science, 361 810
Necrosulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5225 | 58 |