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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Structure
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone structure
CAS No.
394-32-1
Chemical Name:
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
Synonyms
1-(5-FLUORO-2-HYDROXYPHENYL)ETHAN-1-ONE;5-FLUORO-2-HYDROXYACETOPHENONE;2-Acety-4-fluorophenol;1-(5-FLUORO-2-HYDROXY-P;2-Acetyl-4-fluorophenol;2-hydroxy-5-fluorophenone;2-HYDROXY-5-FLUOROACETOPHENONE;5'-Fluoro-2'-hydroxyacetopheno;5'-FLUORO-2'-HYDROXYACETOPHENONE;5’-fluoro-2’-hydroxy-acetophenon
CBNumber:
CB6267638
Molecular Formula:
C8H7FO2
Molecular Weight:
154.14
MDL Number:
MFCD00011668
MOL File:
394-32-1.mol
MSDS File:
SDS
Last updated:2024-03-07 16:58:36
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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Properties

Melting point 56-58 °C(lit.)
Boiling point 65-66 °C8 mm Hg(lit.)
Density 1.1850 (estimate)
Flash point 65-66°C/8mm
storage temp. Inert atmosphere,Room Temperature
pka 10.17±0.18(Predicted)
form powder to crystal
color White to Gray to Brown
Water Solubility Soluble 0.68 G/L
BRN 2359087
CAS DataBase Reference 394-32-1(CAS DataBase Reference)
FDA UNII UE6FHC9K7M
NIST Chemistry Reference 5-Fluoro-2-hydroxyacetophenone(394-32-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  26-37/39-36/37/39
WGK Germany  3
RTECS  AM8502300
HazardClass  IRRITANT
HS Code  29147000
NFPA 704
1
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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 247170 5′-Fluoro-2′-hydroxyacetophenone 98% 394-32-1 5g $31.3 2024-03-01 Buy
Sigma-Aldrich 247170 5′-Fluoro-2′-hydroxyacetophenone 394-32-1 1g $28.5 2022-05-15 Buy
TCI Chemical F0318 5'-Fluoro-2'-hydroxyacetophenone >98.0%(GC) 394-32-1 5g $35 2024-03-01 Buy
TCI Chemical F0318 5'-Fluoro-2'-hydroxyacetophenone >98.0%(GC) 394-32-1 25g $89 2024-03-01 Buy
Alfa Aesar A15614 5'-Fluoro-2'-hydroxyacetophenone, 98% 394-32-1 5g $61.7 2021-12-16 Buy
Product number Packaging Price Buy
247170 5g $31.3 Buy
247170 1g $28.5 Buy
F0318 5g $35 Buy
F0318 25g $89 Buy
A15614 5g $61.7 Buy

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Chemical Properties,Uses,Production

Chemical Properties

light yellow to beige-brown crystals 

Uses

5′-Fluoro-2′-hydroxyacetophenone has been used in the preparation of:

  • 1-(5-fluoro-2-hydroxyphenyl)-3-hydroxy-5-phenyl-2,4-pentadien-1-one
  • 3-hydroxy and 3-methoxyflavones
  • 3-hydroxy and 3-methoxy 2-styrylchromones

Definition

ChEBI: 1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one is an aromatic ketone.

Preparation

Preparation by Fries rearrangement of 4-fluorophenyl acetate with aluminium chloride without solvent between 115° and 150° (88–89%).

General Description

5-fluoro-2-hydroxy acetophenone, also known as 2-ethanoyl-4-fluorophenol or 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone, is a kind of important medicine intermediate, can be used as multiple beta-blockers synthetic intermediate, has vast market prospect.

Synthesis

The preparation method of 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone under following steps:
Performing double esterification on amino groups and phenolic hydroxy in one step by taking amino-phenol as a raw material.
Performing Fries rearrangement under the condition of aluminum chloride/sodium chloride.
Heating a hydrolyzate after completing fluorine diazotization to obtain finished 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone.

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone synthesis

371-41-5
75-36-5
394-32-1
Synthesis of 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone from 4-Fluorophenol and Acetyl chloride

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

2-chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone 6-FLUOROCHROMONE 1-(2-ethoxy-5-fluorophenyl)ethan-1-one 2-(2-Aanilino-4-thiazolyl)-4-fluorophenol 1-(2-Hydroxy-5-fluorophenyl)ethanol
6-FLUOROCHROMONE-3-CARBOXYLIC ACID 97

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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Suppliers

Global( 389)Suppliers
Supplier Tel Email Country ProdList Advantage
Gansu Lizhong New Material Technology Co.,LTD 		13088788637 19993134645 1984863666@qq.com China 10 58
Zhengzhou Anbu Chem Co.,Ltd
+86-0371-88006763; +8615988602810 sales@anbuchem.com China 2998 58
Shandong Juchuang Chemical Co., LTD 		+undefined15030412209 admin@juchuangchem.com China 387 58
Hebei Mojin Biotechnology Co.,Ltd 		+86-15028179902 angelia@hbmojin.com China 1177 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18777 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29882 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10310 58
Supplier Advantage
Gansu Lizhong New Material Technology Co.,LTD 		58
Zhengzhou Anbu Chem Co.,Ltd
58
Shandong Juchuang Chemical Co., LTD 		58
Hebei Mojin Biotechnology Co.,Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58

View Lastest Price from 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5'-Fluoro-2'-hydroxyacetophenone pictures 2024-11-25 5'-Fluoro-2'-hydroxyacetophenone
394-32-1
 US $0.00-0.00 / kg 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone pictures 2024-09-07 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
394-32-1
 US $0.00 / kg 1kg 99% 50000KG/month Hebei Mojin Biotechnology Co.,Ltd
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone pictures 2024-08-15 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
394-32-1
 US $1.00 / KG 1KG 98% 1000KGS Zhengzhou Anbu Chem Co.,Ltd

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Spectrum

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone(394-32-1)MS1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone(394-32-1)1HNMR1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone(394-32-1)13CNMR1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone(394-32-1)IR11-(5-Fluoro-2-hydroxyphenyl)-1-ethanone(394-32-1)IR21-(5-Fluoro-2-hydroxyphenyl)-1-ethanone(394-32-1)Raman

394-32-1(1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone)Related Search:

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 6-Fluoro-4-chromanone 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE 2'-FLUORO-6'-HYDROXYACETOPHENONE
1-(3-FLUORO-4-HYDROXYPHENYL)-1-ETHANONE 4'-Fluoro-2'-hydroxyacetophenone 1-(2-FLUORO-4-HYDROXYPHENYL)-1-ETHANONE 2'-Hydroxyacetophenone 4-Fluorophenol
6-FLUORO-2-METHYL-4-CHROMANONE 6-FLUORO-3-FORMYLCHROMONE 6-FLUORO-2-METHYL-10-OXO-10H-9-OXA-1-AZA-ANTHRACENE-3-CARBOXYLIC ACID METHYL 7-FLUORO-2-(METHOXYMETHYL)-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE 7-FLUORO-2-METHYL-5-OXO-N-[3-(TRIFLUOROMETHYL)PHENYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE
(E)-3-(4-CHLOROBENZYLIDENE)-6-FLUORO-2,3-DIHYDROCHROMEN-4-ONE N-(4-CHLOROPHENYL)-7-FLUORO-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 6-FLUORO-2-METHYL-10-OXO-10H-9-OXA-1-AZA-ANTHRACENE-3-CARBOXYLIC ACID METHYL ESTER

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2-Acetyl-4-fluorophenol 1-(5-FLUORO-2-HYDROXY-P 5-Fluoro-2-hydroxyphenyl(methyl) ketone 5'-Fluoro-2'-hydroxyacetophenone,97% 5’-fluoro-2’-hydroxy-acetophenon Ethanone, 1-(5-fluoro-2-hydroxyphenyl)- 5'-FLUORO-2'-HYDROXYACETOPHENONE 2-HYDROXY-5-FLUOROACETOPHENONE 1-(5-FLUORO-2-HYDROXY-PHENYL)ETHANONE 1-(5-FLUORO-2-HYDROXYPHENYL)-1-ETHANONE 5'-Fluoro-2'-Hydroxyacetophenone 1-(5-Fluoro-2-Hydroxyphenyl)ethan-1-one 2-Hydroxy-5-Fluoroacetophenone99% 5-Fluoro-2-hydroxyacetophenone,98% 5'-Fluoro-2'-hydroxyacetopheno 2-Acety-4-fluorophenol 5'-fluoro-2'-hydroxyacetophenone,1-(5-fluoro-2-hydroxy)ethanone 1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-4-fluorophenol JRH-01009, 1-(5-Fluoro-2-hydroxyphenyl)ethanone, 97% 5'-Fluoro-2'-hydroxyacetophenone> 2-hydroxy-5-fluorophenone 5’-Fluoro-2’-hydroxyacetophenone,1-(5-Fluoro-2-hydroxyphenyl)ethanone,5‘-Fluoro-2‘-hydroxyacetophenone,5'-Fluoro-2'-hydroxyacetophenone TIANFUCHEM 394-32-1 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 5-FLUORO-2-HYDROXYACETOPHENONE 1-(5-FLUORO-2-HYDROXYPHENYL)ETHAN-1-ONE 1-(5-Fluor-2-hydroxyphenyl)ethan-1-on 1-(5-fluro-2-hydroxyphenyl)ethanone 5'-Fluoro-2'-hydroxyacetophenone 394-32-1 Building Blocks Carbonyl Compounds C7 to C8 KETONE Ketones Organic Building Blocks Aryl Fluorinated Building Blocks Building Blocks C7 to C8 C7-C8 Chemical Synthesis Fluorinated Building Blocks Organic Building Blocks Organic Fluorinated Building Blocks Other Fluorinated Organic Building Blocks Acetophenone series Adehydes, Acetals & Ketones Fluorine Compounds Phenols C7 to C8 Carbonyl Compounds Ketones Aromatic Acetophenones & Derivatives (substituted) ketone (intermediate of nebivolol) Benzenes Alcohols and Derivatives Carbonyl Compounds 1