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EPZ004777 HCl

EPZ004777 HCl structure

CAS No.: 1380316-03-9

Chemical Name:: EPZ004777 HCl

Synonyms: EPZ004777 HCl;EPZ004777 (hydrochloride);7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-ribofuranos;7H-pyrrolo[2,3-d]pyrimidin-4-amine,7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylEthyl)phenyl]amino]carbonyl]amino]propyl](1-methylEthyl)amino]-β-D-ribofuranosyl]-,hydrochloride(1:1);1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea hydrochloride

CBNumber:: CB62677400

Molecular Formula:: C28H42ClN7O4

Molecular Weight:: 576.14

MDL Number:: MFCD27920717

MOL File:: 1380316-03-9.mol

Last updated:2024-07-02 08:55:13

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EPZ004777 HCl Properties

storage temp.	4°C, protect from light
solubility	insoluble in H2O; ≥16.5 mg/mL in DMSO; ≥26.35 mg/mL in EtOH
form	Powder
color	Light yellow to yellow

EPZ004777 HCl price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ApexBio Technology	B1581	EPZ004777HCl	1380316-03-9	5mg	$110	2021-12-16	Buy
ApexBio Technology	B1581	EPZ004777HCl	1380316-03-9	50mg	$550	2021-12-16	Buy

Product number	Packaging	Price	Buy
B1581	5mg	$110	Buy
B1581	50mg	$550	Buy

EPZ004777 HCl Chemical Properties,Uses,Production

Biological Activity

epz004777 is a potent and selective inhibitor of dot1l, a protein methyltransferase catalyzing the methylation of lysine 4 of histone h3 (h3k4), with the half maximal inhibition concentration ic50 value of 400 pm [1].epz004777 has been found to concentration-dependently inhibit the h3k79 methylation in a variety of mixed lineage leukemia (mll) cells, including mll-rearranged acute myeloid leukemia (molm-13 and mll-af9), mll-rearranged biphenotypic leukemia (mv4-11 and mll-af4) and non-mll-rearranged t cell acute leukemia cells [1].additionally, epz004777 exhibits anti-proliferative activity against both mll-rearranged and non-rearranged human leukemia cell lines, including rs4;11 (ic50: 6.47 μm), sem (ic50: 1.72 μm), mv4-11 (ic50: 0.17 μm), thp-1 (ic50: 3.36 μm), molm-13 (ic50: 0.72 μm), kopn-8 (ic50: 0.62 μm), reh (ic50: 13.9 μm), kasumi-1 (ic50: 32.99 μm) and 697 (ic50: 36.57 μm) [1].

target

DOT1L

References

[1] daigle sr, olhava ej, therkelsen ca, majer cr, sneeringer cj, song j, johnston ld, scott mp, smith jj, xiao y, jin l, kuntz kw, chesworth r, moyer mp, bernt km, tseng jc, kung al, armstrong sa, copeland ra, richon vm, pollock rm. selective killing of mixed lineage leukemia cells by a potent small-molecule dot1l inhibitor. cancer cell. 2011 jul 12;20(1):53-65. doi: 10.1016/j.ccr.2011.06.009.

EPZ004777 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

EPZ004777 HCl Suppliers

Global( 27)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	sales@newcanbio.com	China	9980	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Jinan Trio PharmaTech Co., Ltd.	+86 (531) 88811783	sales@trio-pharmatech.com (International market)	China	1856	62
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
LETOPHARM LIMITED	+86-21-5821 5861	sales@letopharm.com	China	2384	58
SPIRO PHARMA		eric_feng1954@126.com	China	9254	55
Target molecule Corp.	857-239-0968	service1@targetmol.com	United States	2559	60
Zhongshan Geometric Biological Technology Co., Ltd.	+86-13168912896		China	253	58

Supplier	Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
NewCan Biotech Limited	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Jinan Trio PharmaTech Co., Ltd.	62
MedChemexpress LLC	58
LETOPHARM LIMITED	58
SPIRO PHARMA	55
Target molecule Corp.	60
Zhongshan Geometric Biological Technology Co., Ltd.	58

EPZ004777 HCl Spectrum

EPZ004777 HCl(1380316-03-9)¹HNMR

7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-ribofuranos EPZ004777 HCl EPZ004777 (hydrochloride) 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea hydrochloride 7H-pyrrolo[2,3-d]pyrimidin-4-amine,7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylEthyl)phenyl]amino]carbonyl]amino]propyl](1-methylEthyl)amino]-β-D-ribofuranosyl]-,hydrochloride(1:1) 1380316-03-9 C28H41N7O4HCl Inhibitors