ChemicalBook >> CAS DataBase List >>PF 06465469 Discontinued See A191400

PF 06465469 Discontinued See A191400

PF 06465469 Discontinued See A191400 structure

CAS No.: 1407966-77-1

Chemical Name:: PF 06465469 Discontinued See A191400

Synonyms: PF 06465469;PF06465469,PF 06465469;PF 06465469 Discontinued See A191400;3-[4-amino-1-[(3R)-1-prop-2-enoyl-3-piperidyl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-3-methyl-phenyl)benzamide;(R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-aMino-1H-pyrazolo[3,4-d]pyriMidin-3-yl]-N-(4-isopropyl-5-Methylphenyl)benzaMide;(R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(3-methyl-4-(1-methylethyl))benzamide;3-[4-Amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-benzamide;Benzamide, 3-[4-amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-

CBNumber:: CB62694359

Molecular Formula:: C30H33N7O2

Molecular Weight:: 523.63

MDL Number:: MFCD23381175

MOL File:: 1407966-77-1.mol

Last updated:2023-07-12 16:41:50

Request For Quotation

PF 06465469 Discontinued See A191400 Properties

Melting point	209-212°C
Boiling point	730.2±60.0 °C(Predicted)
Density	1.30±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble5mg/mL, clear
pka	12.83±0.70(Predicted)
form	powder
color	white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37
WGK Germany	3

PF 06465469 Discontinued See A191400 price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PZ0209	PF-06465469 ≥97% (HPLC)	1407966-77-1	5mg	$128	2024-03-01	Buy
Sigma-Aldrich	PZ0209	PF-06465469 ≥97% (HPLC)	1407966-77-1	25mg	$496	2024-03-01	Buy
Tocris	4710	PF06465469 ≥95%(HPLC)	1407966-77-1	10	$300	2021-12-16	Buy
Tocris	4710	PF06465469 ≥95%(HPLC)	1407966-77-1	50	$1208	2021-12-16	Buy
TRC	A191400	(R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-5-methylphenyl)benzamide	1407966-77-1	2.5mg	$385	2021-12-16	Buy

Product number	Packaging	Price	Buy
PZ0209	5mg	$128	Buy
PZ0209	25mg	$496	Buy
4710	10	$300	Buy
4710	50	$1208	Buy
A191400	2.5mg	$385	Buy

PF 06465469 Discontinued See A191400 Chemical Properties,Uses,Production

Chemical Properties

Beige Solid

Uses

PF 06465469 is a covalent Inhibitors of Interleukin-2 Inducible T Cell Kinase (Itk) with nanomolar potency in a whole-blood assay.

Uses

(R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-5-methylphenyl)benzamide is a potential covalent inhibitor of Interleukin-2 Inducible T Cell KInase (Itk). Itk is a member of the TEC-kinase family and is associated with the induction of T cell proliferation and drives cytokines through NFATc.

storage

Store at +4°C

PF 06465469 Discontinued See A191400 Preparation Products And Raw materials

Raw materials

Preparation Products

PF 06465469 Discontinued See A191400 Suppliers

Global( 38)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50
Shanghai TaoSu Biochemical Technology Co., Ltd.	021-33632979	info@tsbiochem.com	China	8073	58
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2991	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
InvivoChem	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
J & K SCIENTIFIC LTD.	76
Chemsky（shanghai）International Co.,Ltd.	50
Shanghai TaoSu Biochemical Technology Co., Ltd.	58
EMMX Biotechnology LLC	60
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai Rechem science Co., Ltd.	58

PF 06465469 Discontinued See A191400 (R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-aMino-1H-pyrazolo[3,4-d]pyriMidin-3-yl]-N-(4-isopropyl-5-Methylphenyl)benzaMide PF 06465469 3-[4-Amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-benzamide (R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(3-methyl-4-(1-methylethyl))benzamide Benzamide, 3-[4-amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]- PF06465469,PF 06465469 3-[4-amino-1-[(3R)-1-prop-2-enoyl-3-piperidyl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-3-methyl-phenyl)benzamide 1407966-77-1 Aromatics, Heterocycles, Inhibitors, Pfizer Compounds, Pharmaceuticals, Intermediates & Fine Chemicals Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals