LL-Z-1640-2
- CAS No.
- 66018-38-0
- Chemical Name:
- LL-Z-1640-2
- Synonyms
- LL-Z-1640-2;C292, L 783278;JNK/p38 inhibitor;(5Z)-7-Oxozeaenol;(5Z)-7-Oxozeaenol (5Z-7-oxozeaenol);5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione;(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
- CBNumber:
- CB6270733
- Molecular Formula:
- C19H22O7
- Molecular Weight:
- 362.37
- MDL Number:
- MFCD12912700
- MOL File:
- 66018-38-0.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Warning |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310a-P321-P405-P501a |
| Hazard Codes | Xi |
LL-Z-1640-2 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 499610 | (5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem (5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC = 8 nM). |
66018-38-0 | 1mg | $159 | 2024-03-01 | Buy |
| Alfa Aesar | J66651 | 5Z-7-Oxozeaenol | 66018-38-0 | 1mg | $125.65 | 2024-03-01 | Buy |
| Alfa Aesar | J66651 | 5Z-7-Oxozeaenol | 66018-38-0 | 5mg | $509.65 | 2024-03-01 | Buy |
| Tocris | 3604 | (5Z)-7-Oxozeaenol ≥98%(HPLC) | 66018-38-0 | 1 | $176 | 2021-12-16 | Buy |
| TRC | A697425 | AntibioticLLZ1640-2 | 66018-38-0 | 1mg | $105 | 2021-12-16 | Buy |
LL-Z-1640-2 Chemical Properties,Uses,Production
Uses
LL Z1640-2 is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models.
Biological Activity
Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor- β -activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC 50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF- κ B (IC 50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF- α -induced apoptosis in vitro .
LL-Z-1640-2 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8617 | 58 |